Patents by Inventor Dorothy Mcculloch
Dorothy Mcculloch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230172496Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.Type: ApplicationFiled: September 19, 2022Publication date: June 8, 2023Inventors: John Kenneth Hicks, Richard Hoskins, Stephen Rimmer, Dorothy McCulloch
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Patent number: 11504033Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.Type: GrantFiled: January 13, 2017Date of Patent: November 22, 2022Assignees: Smith & Nephew PLC, University of SheffieldInventors: John Kenneth Hicks, Richard Hoskins, Stephen Rimmer, Dorothy McCulloch
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Patent number: 11471076Abstract: Device comprising polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicator monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.Type: GrantFiled: January 13, 2017Date of Patent: October 18, 2022Assignees: Smith & Nephew PLC, University of SheffieldInventors: John Kenneth Hicks, Richard Hoskins, Stephen Rimmer, Dorothy McCulloch
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Publication number: 20210372975Abstract: Disclosed herein are devices, wound dressings and methods for determining the pH of fluid or a wound exudate at a wound. Example devices include a device comprising a surface configured to contact the fluid or wound and a pH indicator covalently bound thereto or applied to the surface, wherein the pH indicator has a first colour prior to contact with the fluid or the wound exudate and changes colour as a function of the pH of the fluid or wound exudate. Example devices include a device which indicates wound exudate loading within a wound dressing and wound dressing comprising an absorbent layer and a moisture indicator which indicates would exudate loading within the dressing, wherein the visibility of the moisture indictor changes as a result of a physical transformation of a first material within the dressing. Systems, devices, and methods are provided for monitoring wound status and progression by measuring pH levels indicated by pH-sensitive wound dressings.Type: ApplicationFiled: May 14, 2021Publication date: December 2, 2021Inventors: Sebastien Antoine Yves Cuvelier, Anthony Dagger, Nicholas Charlton Fry, Victoria Jody Hammond, Edward Yerbury Hartwell, John Kenneth Hicks, Alexander Speirs Laurie, Helene Anne Lecomte, Dorothy McCulloch, Ella Lynn Mumby, Mark Richardson, Carl Saxby, Rhianna Ward, Benjamin Wicks
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Device including a polymeric material for detecting species and stimulus and method of using thereof
Patent number: 10782238Abstract: A device for sensing and/or detecting species or stimulus at a locus, preferably at a fluid or moist locus by means of fluid communication therewith, comprising a surface configured to contact the locus, wherein the surface comprises a polyurethane material which material comprises a polyurethane polymer network having a hydrophilic polymer immobilised therein wherein the hydrophilic polymer comprises immobilised therein a ligand or moiety for detecting or sensing species or stimulus and an indicator for indicating detection or sensing prior to contact with the locus and change in indication as a function of species or stimulus present at the locus wherein species or stimulus are selected from chemical and biological species or stimulus; the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; and a Kit.Type: GrantFiled: July 3, 2015Date of Patent: September 22, 2020Assignees: Smith & Nephew PLC, University of SheffieldInventors: John Kenneth Hicks, Stephen Rimmer, Richard Hoskins, Dorothy McCulloch -
Patent number: 10520446Abstract: A polyurethane material for the detection or sensing of species or stimulus comprising a polyurethane network comprising immobilized therein, or modified by the immobilization therein of, a hydrophilic polymer comprising a ligand or moiety for the detection or sensing of species or stimulus and an indicator for indicating detection or sensing wherein species or stimulus is selected from chemical or biological species or stimulus; the material for medical, dental, hygiene, point of use sterilization, sanitation, personal care, biosurveillance or packaging use, the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; a Kit and a device comprising the same; and a process for the preparation thereof.Type: GrantFiled: July 3, 2015Date of Patent: December 31, 2019Assignees: Smith & Nephew PLC, University of SheffieldInventors: John Kenneth Hicks, Stephen Rimmer, Dorothy McCulloch, Richard Hoskins
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Publication number: 20190212311Abstract: Disclosed herein are devices, wound dressings and methods for determining the pH of fluid or a wound exudate at a wound. Example devices include a device comprising a surface configured to contact the fluid or wound and a pH indicator covalently bound thereto or applied to the surface, wherein the pH indicator has a first colour prior to contact with the fluid or the wound exudate and changes colour as a function of the pH of the fluid or wound exudate. Example devices include a device which indicates wound exudate loading within a wound dressing and wound dressing comprising an absorbent layer and a moisture indicator which indicates would exudate loading within the dressing, wherein the visibility of the moisture indictor changes as a result of a physical transformation of a first material within the dressing. Systems, devices, and methods are provided for monitoring wound status and progression by measuring pH levels indicated by pH-sensitive wound dressings.Type: ApplicationFiled: January 7, 2019Publication date: July 11, 2019Inventors: Victoria Jody Hammond, John Kenneth Hicks, Edward Yerbury Hartwell, Dorothy Mcculloch, Mark Richardson, Carl Saxby, Anthony Dagger, Nicholas Charlton Fry, Alexander Speirs Laurie, Helene Anne Lecomte, Rhianna Moss, Ella Lynn Mumby, Sebastien Antoine Yves Cuvelier, Benjamin Wicks
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Publication number: 20190015028Abstract: Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.Type: ApplicationFiled: January 13, 2017Publication date: January 17, 2019Inventors: John Kenneth HICKS, Richard HOSKINS, Stephen RIMMER, Dorothy MCCULLOCH
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Publication number: 20190008428Abstract: Device comprising polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising: hydrophilic monomer; and indicator monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer; characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10 and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.Type: ApplicationFiled: January 13, 2017Publication date: January 10, 2019Inventors: John Kenneth HICKS, Richard HOSKINS, Stephen RIMMER, Dorothy MCCULLOCH
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Publication number: 20170234802Abstract: A device for sensing and/or detecting species or stimulus at a locus, preferably at a fluid or moist locus by means of fluid communication therewith, comprising a surface configured to contact the locus, wherein the surface comprises a polyurethane material which material comprises a polyurethane polymer network having a hydrophilic polymer immobilised therein wherein the hydrophilic polymer comprises immobilised therein a ligand or moiety for detecting or sensing species or stimulus and an indicator for indicating detection or sensing prior to contact with the locus and change in indication as a function of species or stimulus present at the locus wherein species or stimulus are selected from chemical and biological species or stimulus; the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; and a Kit.Type: ApplicationFiled: July 3, 2015Publication date: August 17, 2017Inventors: John Kenneth Hicks, Stephen RIMMER, Richard HOSKINS, Dorothy MCCULLOCH
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Publication number: 20170183705Abstract: A polyurethane material for the detection or sensing of species or stimulus comprising a polyurethane network comprising immobilised therein, or modified by the immobilisation therein of, a hydrophilic polymer comprising a ligand or moiety for the detection or sensing of species or stimulus and an indicator for indicating detection or sensing wherein species or stimulus is selected from chemical or biological species or stimulus; the material for medical, dental, hygiene, point of use sterilisation, sanitation, personal care, biosurveillance or packaging use, the use thereof preferably for detecting and/or sensing or binding bacteria, or for detecting or sensing pH or for detection or scanning with use of a reader; a Kit and a device comprising the same; and a process for the preparation thereofType: ApplicationFiled: July 3, 2015Publication date: June 29, 2017Applicant: Smith & Nephew PLCInventors: John Kenneth HICKS, Stephen RIMMER, Dorothy MCCULLOCH, Richard HOSKINS
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Publication number: 20160262672Abstract: Disclosed herein are devices, wound dressings and methods for determining the pH of wound exudate at a wound. Example devices include a device comprising a surface configured to contact the wound and a pH indicator applied to the surface, wherein the pH indicator has a first colour prior to contact with the wound exudate and changes colour as a function of the pH of the wound exudate.Type: ApplicationFiled: October 8, 2014Publication date: September 15, 2016Applicant: Smith & Nephew PLCInventors: Victoria Jody Hammond, Edward Yerbury Hartwell, John Kenneth Hicks, Dorothy Mcculloch, Mark Richardson, Carl Saxby