Abstract: The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases including atopic dermatitis (eczema), asthma, psoriasis and allergies (including food allergy).

Abstract: A foldable and collapsible jewelry storage device including a flexible substratum having a top portion and two opposing substantially planar surfaces, a plurality of pockets disposed on at least one of the surfaces, and an attachment clasp disposed adjacent to a top edge of at least one of the pockets. A hanger is attached to the top portion of the substratum to provide a point of attachment to a rigid body, such as a closet rod. Each of the pockets comprises a flexible translucent strip attached to the substratum along at least the lower edge and sides of the strip, leaving the top edge open, forming a storage pocket. The pockets are spaced apart and arranged in a matrix or grid. The attachment clasp provides enhanced organization for longer jewelry pieces and prevents kinking and tangling. The substratum may comprise two layers with a hanger disposed between the two.

Abstract: The present invention relates to the prevention/treatment of ichthyosis vulgaris (IV), atopy and potentially other disorders associated with loss-of-function mutations in the filaggrin gene sequence. The prevention/therapy is based on the use of agents which enable the host's translational machinery to read through a nonsense mutation found in a mutant allele of the filaggrin gene.

Abstract: The present invention relates to the prevention/treatment of ichthyosis vulgaris (IV), atopy and potentially other disorders associated with loss-of-function mutations in the filaggrin gene sequence. The prevention/therapy is based on the use of agents which enable the host's translational machinery to read through a nonsense mutation found in a mutant allele of the filaggrin gene.

Abstract: The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Abstract: The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Abstract: The present invention relates to the identification of loss-of-function mutations in the filaggrin gene and their use in diagnosing ichthyosis vulgaris and/or susceptibility to other diseases including atopic dermatitis (eczema), asthma, psoriasis and allergies (including food allergy).

Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Abstract: The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Abstract: The present invention is directed to the discovery of a new class of androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease sebum secretion and to stimulate hair growth.

Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Abstract: A collapsable, foldable jewelry organizer and storage device capable of being hung from a closet rod or protrusion, which renders the jewelry objects stored thereby individually visible to the user, is disclosed. The device comprises a flexible substratum having a plurality of flexible transparent or translucent pockets within which jewelry objects may be stored. The pockets may be of various sizes and may be arranged in a matrix configuration. The substratum is supported from the bottom edge of a hanger by means of the interaction of the bottom edge of the hanger with a tube extending around the bottom edge of the hanger. The tube is attached to the substratum along the top edge of the substratum allowing the device to be hung from a closet rod or similar protrusion.

Abstract: A harness is disclosed that joins a child to a companion by means of an inelastic strap. The strap is joined at one end by a snap hook to one of a plurality of rings spaced along an adult's waistband. At the other end, the strap has a snap hook that connects to a pair of rings each connected to a respective one of a pair of crossing shoulder straps on a child's harness. The shoulder straps are attached to a waistband having a clasp to be positioned at the rear of the child and the straps cross across the back of the child. The harness, waistband and strap are all formed of a woven fabric.