Patents by Inventor Dos Sarbassov

Dos Sarbassov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complexes comprising mammalian raptor polypeptide and mammalian mTOR polypeptide
    Patent number: 8809500
    Abstract: The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: August 19, 2014
    Assignee: Whitehead Institute For Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos Sarbassov
  • Nucleic Acids Encoding a Mammalian Raptor Polypeptide and Uses Therefor
    Publication number: 20140004532
    Abstract: The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.
    Type: Application
    Filed: June 14, 2013
    Publication date: January 2, 2014
    Applicant: Whitehead Institute For Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos Sarbassov
  • Methods relating to mammalian raptor polypeptide
    Patent number: 8486643
    Abstract: The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: July 16, 2013
    Assignee: Whitehead Institute For Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos Sarbassov
  • Nucleic Acids Encoding a Mammalian Raptor Polypeptide and Uses Therefor
    Publication number: 20110143370
    Abstract: The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.
    Type: Application
    Filed: October 7, 2010
    Publication date: June 16, 2011
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos Sarbassov
  • Nucleic acids encoding a mammalian raptor polypeptide and uses therefor
    Publication number: 20080260721
    Abstract: The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.
    Type: Application
    Filed: April 18, 2007
    Publication date: October 23, 2008
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos Sarbassov
  • mTOR kinase-associated proteins
    Publication number: 20070009936
    Abstract: The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
    Type: Application
    Filed: May 17, 2006
    Publication date: January 11, 2007
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: David Sabatini, Do-Hyung Kim, Dos Sarbassov
  • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    Publication number: 20060194271
    Abstract: In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.
    Type: Application
    Filed: January 27, 2006
    Publication date: August 31, 2006
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: David Sabatini, Dos Sarbassov
  • Nucleic acids encoding a mammalian raptor polypeptide and uses therefor
    Publication number: 20040072207
    Abstract: The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.
    Type: Application
    Filed: May 13, 2003
    Publication date: April 15, 2004
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: David M. Sabatini, Do-Hyung Kim, Dos Sarbassov