Patents by Inventor Doug E. Frantz

Doug E. Frantz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of HIF-2? heterodimerization with HIF1? (ARNT)
    Patent number: 9757379
    Abstract: Provided is a method of inhibiting heterodimerization of HIF-2? to HIF1? (ARNT) comprising binding certain small molecules to the HIF-2? PAS-B domain cavity but not to HIF1? and inhibiting HIF-2? heterodimerization to HIF1? (ARNT) but not inhibiting HIF1? heterodimerization to HIF1? (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2? heterodimerization inhibitors and also simply as certain small molecules.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: September 12, 2017
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Richard K. Bruick, Charles G. Caldwell, Doug E. Frantz, Kevin H. Gardner, John B. MacMillan, Thomas H. Scheuermann, Uttam K. Tambar
  • INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT)
    Publication number: 20160250216
    Abstract: Provided is a method of inhibiting heterodimerization of HIF-2? to HIF1? (ARNT) comprising binding certain small molecules to the HIF-2? PAS-B domain cavity but not to HIF1? and inhibiting HIF-2? heterodimerization to HIF1? (ARNT) but not inhibiting HIF1? heterodimerization to HIF1? (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2? heterodimerization inhibitors and also simply as certain small molecules.
    Type: Application
    Filed: November 14, 2013
    Publication date: September 1, 2016
    Applicant: tHE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Richard K. BRUICK, Charles G. CALDWELL, Doug E. FRANTZ, Kevin H. GARDNER, John B. MACMILLAN, Thomas H. SCHEUERMANN, Uttam K. TAMBAR
  • Synthesis of acylated keto amides from sulfonyl amides
    Publication number: 20030083503
    Abstract: Acylated ketoamides are prepared from sulfonyl amides and aldehydes or their related derivatives by a step of 1
    Type: Application
    Filed: June 20, 2002
    Publication date: May 1, 2003
    Inventors: Doug E. Frantz, Lisa F. Frey, Karen Marcantonio, Jerry Anthony Murry, Richard Tillyer