Patents by Inventor Douglas Golenbock

Douglas Golenbock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR REDUCING INFLAMMATION AND TREATING INFLAMMATORY DISORDERS
    Publication number: 20100150938
    Abstract: Methods of treating an inflammatory disorder and inhibiting inflammation by administering an inhibitor of a pH-activated protease are provided.
    Type: Application
    Filed: July 2, 2009
    Publication date: June 17, 2010
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: Eicke Latz, Douglas Golenbock, Kenneth L. Rock, Veit Hornung, Annett Halle
  • Methods of treating disorders associated with toll-like receptor 4 (TLR4) signalling
    Publication number: 20060241040
    Abstract: Described herein are methods and compositions for treating, preventing, and diagnosing disorders associated with TLR4 signalling, e.g., gram negative bacterial infection and sterile inflammations such as rheumatoid arthritis.
    Type: Application
    Filed: April 6, 2006
    Publication date: October 26, 2006
    Inventors: Alberto Visintin, Douglas Golenbock
  • Toll-like receptor 9 modulators
    Publication number: 20060127884
    Abstract: TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described.
    Type: Application
    Filed: January 26, 2006
    Publication date: June 15, 2006
    Inventors: Eicke Latz, Alberto Visintin, Douglas Golenbock
  • Toll-like receptor assays
    Publication number: 20060099650
    Abstract: Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR are described. Methods of identifying molecules that interact with a TLR are also described.
    Type: Application
    Filed: January 6, 2006
    Publication date: May 11, 2006
    Inventors: Eicke Latz, Alberto Visintin, Douglas Golenbock
  • Toll-like receptor 9 modulators
    Publication number: 20050255451
    Abstract: TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described.
    Type: Application
    Filed: December 16, 2004
    Publication date: November 17, 2005
    Inventors: Eicke Latz, Alberto Visintin, Douglas Golenbock
  • Toll-like receptor assays
    Publication number: 20050208470
    Abstract: Methods of identifying compounds that modulate the interaction between a TLR and a molecule that interacts with the TLR by direct binding or by inclusion in a complex that associates with the TLR are described. Methods of identifying molecules that interact with a TLR are also described.
    Type: Application
    Filed: December 16, 2004
    Publication date: September 22, 2005
    Applicant: University of Massachusetts
    Inventors: Eicke Latz, Alberto Visintin, Douglas Golenbock
  • TRIF-related adaptor molecule (TRAM) and uses thereof
    Publication number: 20050158799
    Abstract: A Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-? (TRIF)-related adaptor molecule (TRAM) has been identified. TRAM acts specifically in the TLR4 signaling pathway. The invention includes compounds useful for modulating TLR signaling by modulating the effects of TRAM.
    Type: Application
    Filed: October 18, 2004
    Publication date: July 21, 2005
    Inventors: Katherine Fitzgerald, Daniel Rowe, Douglas Golenbock