Abstract: A body fluid collection device includes a blow-molded unitary plastic container having a pair of integral tube connectors formed in the upper wall for connecting a pair of tubes in fluid communication with the interior of the container. One tube can be connected with a source of vacuum and the other to a source of body fluid. A line of weakness is formed in the container sidewall adjacent the upper end which permits the upper end of the container to be manually opened for removal of collected material for clinical testing. The line of weakness may be a slot, perforation line or an area of reduced wall thickness.