Abstract: A pump includes a flexible conduit, at least one valve attached to the flexible conduit about the perimeter of the valve; and a drive mechanism to move the valve to pump blood within the conduit. The drive mechanism can, for example, be adapted to complete a single stroke during each heart ventricle contraction and/or to complete multiple strokes (that is, oscillate) during a single contraction. Another implantable pump for assisting blood flow, includes: a flexible conduit formed in an arc; at least one movable valve in operative connection with the conduit; and a drive mechanism to move the valve in an arced path to pump blood within the conduit. Another pump includes a conduit and at least one moveable valve within the conduit. The moveable valve includes a plurality of openings. Each of the plurality of openings has a closure mechanism in operative connection therewith.

Abstract: For purposes of determining the function of a protein, an automated system captures images of cells, each cell located in a predetermined well. After a given cell is exposed to a protein of interest, the system measures the responses of the cell over time, evaluating a variety of cellular parameters. Analytical software within the system evaluates data generated by these measurements, at single-cell resolution. By comparing with various controls the data thus obtained, the system illuminates the function of a protein with respect to one or more disease models, independent of information regarding the structure, chemistry or underlying genomics of the protein.

Abstract: An apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes means for analyzing the effect or proteins and other biological and chemical moieties on the cells. A method for monitoring of proteins and cells. A method for analyzing a cells. An apparatus for aligning light in a well of a plate for holding cells. A method for lighting a well. A method for determining a condition of a cell. An apparatus for indicating a condition of a cell. A method for establishing a focus profile of a plate having wells for holding cells. A method for manipulating cells. An apparatus for manipulating cells.