Patents by Inventor Douglas R. Savage
Douglas R. Savage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100312328Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: ApplicationFiled: January 29, 2010Publication date: December 9, 2010Applicant: Biosensors International Group, Ltd.Inventors: John E. SHULZE, Ronald E. Betts, Douglas R. Savage
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Patent number: 7727275Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-di-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: GrantFiled: September 20, 2004Date of Patent: June 1, 2010Assignee: Biosensors International Group, Ltd.Inventors: Ronald E. Betts, Douglas R. Savage
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Publication number: 20100094408Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: ApplicationFiled: December 15, 2009Publication date: April 15, 2010Applicant: Biosensors International Group, LtdInventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Patent number: 7682387Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40–90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1–5 microns.Type: GrantFiled: March 5, 2003Date of Patent: March 23, 2010Assignee: Biosensors International Group, Ltd.Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Publication number: 20100055145Abstract: Devices and methods relate to drug-eluting stents and coatings, thereof, for reduced late stent thrombosis are described.Type: ApplicationFiled: August 29, 2008Publication date: March 4, 2010Applicant: Biosensors International GroupInventors: Ronald E. Betts, Douglas R. Savage, John E. Shulze
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Publication number: 20080097568Abstract: A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments where at least one surface of the filaments has a roughened or abraded surface. The stent may include a therapeutic agent on the abraded surface.Type: ApplicationFiled: March 23, 2007Publication date: April 24, 2008Inventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
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Publication number: 20080097591Abstract: An improvement in drug-eluting stents, and method of their making are disclosed. The surface of a metal stent is roughened to have a surface roughness of at least about 20 ?in (0.5 ?m) and a surface roughness range of between about 300-700 ?in (7.5-17.5 ?m). The roughened stent surface is covered with a polymer-free coating of a limus drug, to a coating thickness greater than the range of surface roughness of the roughened stent surface.Type: ApplicationFiled: May 21, 2007Publication date: April 24, 2008Applicant: BIOSENSORS INTERNATIONAL GROUPInventors: Douglas R. Savage, John E. Shulze, Ronald E. Betts, Sepehr Fariabi, Shih-Horng Su
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Patent number: 7220755Abstract: 42-O-alkoxyalkyl derivatives of rapamycin having biological activity are described. Compositions and delivery devices comprising the 42-O-alkoxyalkyl rapamycin derivatives are also disclosed.Type: GrantFiled: November 12, 2003Date of Patent: May 22, 2007Assignee: Biosensors International Group, Ltd.Inventors: Ronald E. Betts, Douglas R. Savage, John E. Shulze
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Patent number: 6939376Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: GrantFiled: April 24, 2002Date of Patent: September 6, 2005Assignee: Sun Biomedical, Ltd.Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Publication number: 20040030380Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of the macrocyclic triene immunosuppressive compound everolimus. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: ApplicationFiled: March 5, 2003Publication date: February 12, 2004Applicant: Sun Biomedical, Ltd.Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Publication number: 20040024450Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases a restenosis-inhibiting amount of an active compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: ApplicationFiled: March 5, 2003Publication date: February 5, 2004Applicant: Sun Biomedical, Ltd.Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Publication number: 20030225450Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filament body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a macrocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: ApplicationFiled: March 5, 2003Publication date: December 4, 2003Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Publication number: 20030125800Abstract: An intravascular stent and method for inhibiting restenosis, following vascular injury, is disclosed. The stent has an expandable, linked-filamant body and a drug-release coating formed on the stent-body filaments, for contacting the vessel injury site when the stent is placed in-situ in an expanded condition. The coating releases, for a period of at least 4 weeks, a restenosis-inhibiting amount of a monocyclic triene immunosuppressive compound having an alkyl group substituent at carbon position 40 in the compound. The stent, when used to treat a vascular injury, gives good protection against clinical restenosis, even when the extent of vascular injury involves vessel overstretching by more than 30% diameter. Also disclosed is a stent having a drug-release coating composed of (i) 10 and 60 weight percent poly-dl-lactide polymer substrate and (ii) 40-90 weight percent of an anti-restenosis compound, and a polymer undercoat having a thickness of between 1-5 microns.Type: ApplicationFiled: April 24, 2002Publication date: July 3, 2003Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Publication number: 20030088307Abstract: A stent having an expandable stent body with a generally tubular shape comprises a series of support surfaces upon which a polymer stent coating has been applied. One or more bioactive agents are disposed within the coating. The coating is applied by evaporating solvent from a solution which has been applied to the stent surfaces from a pressurized reservoir or positive displacement pumping means attached to a delivery tube. The delivery tube's longitudinal or X-Y-Z position along the body of the stent, the rotation of the stent along its longitudinal axis, and the delivery rate are coordinated by a programmable controller to deposit precise and repeatable amounts of polymer and agent on the stent surfaces. Preferably, an anti-restenosis agent consisting of a potent analogue or derivative of tranilast are disposed in a bioerodable stent coating, comprising poly(lactic acid), or, alternatively, in a biodurable stent coating comprising EVA.Type: ApplicationFiled: May 16, 2002Publication date: May 8, 2003Inventors: John E. Shulze, Ronald E. Betts, Douglas R. Savage
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Patent number: 6364847Abstract: A blood sampling device is provided for mounting on a patient's forearm or other suitable body location, which incorporates an admixture reservoir and a closed blood sampling cavity in a single housing, the functional elements of which are firmly mounted and easily accessible to the caregiver. The blood sampling cavity is preferably accessed by a blunt cannula, which is readily retained in the sampling cavity by virtue of the cavity's secured position and elevated location on the sampling device housing during the sampling procedure, without the need for a cannula locking device.Type: GrantFiled: October 7, 1999Date of Patent: April 2, 2002Assignee: Sunscope International, Inc.Inventors: John E. Shulze, Douglas R. Savage
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Patent number: 6193864Abstract: A blood analyzer sensor cartridge comprises a housing having chamber and a sensor assembly within the chamber, a first fluid port having an articulated inlet aspiration tube for direct introduction of a sample, a first fluid path in the housing communicating the first fluid port with the sensor assembly, a second fluid port in the housing adapted for connection to an analyzer, and a second fluid path in the housing communicating the sensor assembly with the second fluid port, the articulated tube is pivotally mounted to the housing for selective orientation within a range of up to ninety degrees, the tube is moveable from a protective recess in the housing to a position normal to a face of the housing.Type: GrantFiled: November 2, 1998Date of Patent: February 27, 2001Assignee: SenDx Medical, Inc.Inventors: Matthew J. Leader, Douglas R. Savage
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Patent number: 6146510Abstract: The present invention is a sensor formed over a subminiature through hole. Because of the small diameter of the through hole, the material that fills the through hole and the through hole itself have an essentially negligible effect on the sensor. Only a small amount of conductive material which fills each through hole is in contact with each associated electrode. Therefore, the purity of the electrode is not significantly altered by the conductive material coupled to the electrode. A relatively large number of sensors can be formed on the surface of the substrate within a relatively small fluid flowcell. Thus, more information can be attained using less blood. The sensors of the present invention are preferably disposed on an alumina substrate which is essentially impervious to aqueous electrolytes and blood over long periods of storage in potentially corrosive environments.Type: GrantFiled: May 16, 1996Date of Patent: November 14, 2000Assignee: SenDx Medical, Inc.Inventors: Matthew J. Leader, Jeffrey Graves, Douglas R. Savage
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Patent number: 6016683Abstract: A reference solution container for an analyzer for measuring gas and/or electrolyte levels in a fluid. The vessel includes a fluid container for holding a reference solution and a self-sealing fluid port for repeatedly accessing the reference solution in the fluid vessel by a fluid carrying device that is external to the reference solution container. The partial pressure of each gas in the reference solution within the fluid vessel is maintained at a substantially constant level.Type: GrantFiled: October 13, 1998Date of Patent: January 25, 2000Assignee: SenDx Medical, Inc.Inventors: Ronald E. Betts, Douglas R. Savage, Michael C. Weinzierl
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Patent number: 5913232Abstract: A reference solution container for an analyzer for measuring gas and/or electrolyte levels in a fluid. The vessel includes a fluid container for holding a reference solution and a self-sealing fluid port for repeatedly accessing the reference solution in the fluid vessel by a fluid carrying device that is external to the reference solution container. The partial pressure of each gas in the reference solution within the fluid vessel is maintained at a substantially constant level.Type: GrantFiled: May 20, 1996Date of Patent: June 15, 1999Assignee: SenDx Medical, Inc.Inventors: Ronald E. Betts, Douglas R. Savage, Michael C. Weinzierl
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Patent number: 5885533Abstract: A calibration fluid cartridge for a medical device, such as a blood analyzer. The cartridge includes at least one calibrant bag that is filled with a flexible calibration fluid and a flexible waste bag for holding fluid waste from the blood analyzer. The calibrant bags contract as calibration fluid exits the bags, leaving a void in the cartridge that is filled by the waste bag, which expands with waste fluids as the calibrant bags contract. Thus, the cartridge can be made compact and light-weight, making it particularly suited for use in a portable blood analyzer. The calibrant bags have fluid ports with self-sealing valves and a flange to secure them within the cartridge, as well as a compliant member for facilitating a secure, fluid-tight seal between fluid fitting on the blood analyzer and the calibrant and waste bags. The calibrant bags can be directly coupled to the blood analyzer to reduce diffusion of gases from the calibrant bags.Type: GrantFiled: May 20, 1996Date of Patent: March 23, 1999Assignee: SenDx Medical, Inc.Inventors: Douglas R. Savage, Michael C. Weinzierl