Patents by Inventor Douglas T. YAMANISHI
Douglas T. YAMANISHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10006084Abstract: A method including contacting a tissue or cellular sample with a reagent including an evaporation reducing agent(s) having the general formula X1—R—X2, wherein R is an alkyl, alkenyl, alkynyl or an aromatic moiety of 1 or more carbon atoms that may be substituted with an oxygen, nitrogen or sulfur and X1 and X2 are independently selected to be moiety that is susceptible to hydrogen bonding and processing the tissue or cellular sample. A reagent used in the processing of a tissue or cellular sample with the reagent containing an evaporation reducing agent.Type: GrantFiled: April 30, 2015Date of Patent: June 26, 2018Assignee: Sakura Finetek U.S.A., Inc.Inventors: Douglas T. Yamanishi, Clifford Hom, Amit D. Shah
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Publication number: 20170089814Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.Type: ApplicationFiled: December 15, 2016Publication date: March 30, 2017Applicant: AVIVA BIOSCIENCES CORPORATIONInventors: Ping LIN, Douglas T. YAMANISHI, George WALKER, Junquan XU, Mingxian HUANG, Guoliang TAO, Lei WU, Xiaobo WANG, Joe OUYANG, Jing CHENG, Jia XU
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Patent number: 9556485Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.Type: GrantFiled: March 2, 2015Date of Patent: January 31, 2017Assignee: AVIVA BIOSCIENCES CORPORATIONInventors: Ping Lin, Douglas T. Yamanishi, George Walker, Junquan Xu, Mingxian Huang, Guoliang Tao, Lei Wu, Xiaobo Wang, Joe Ouyang, Jing Cheng, Jia Xu
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Publication number: 20160319337Abstract: A method including contacting a tissue or cellular sample with a reagent including an evaporation reducing agent(s) having the general formula X1—R—X2, wherein R is an alkyl, alkenyl, alkynyl or an aromatic moiety of 1 or more carbon atoms that may be substituted with an oxygen, nitrogen or sulfur and X1 and X2 are independently selected to be moiety that is susceptible to hydrogen bonding and processing the tissue or cellular sample. A reagent used in the processing of a tissue or cellular sample with the reagent containing an evaporation reducing agent.Type: ApplicationFiled: April 30, 2015Publication date: November 3, 2016Inventors: Douglas T. YAMANISHI, Clifford HOM, Amit D. SHAH
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Patent number: 9290812Abstract: The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.Type: GrantFiled: May 28, 2014Date of Patent: March 22, 2016Assignee: Aviva Biosciences CorporationInventors: Douglas T. Yamanishi, Paul G. Hujsak, Sara F. Snyder, George Walker, Junquan Xu, Mingxian Huang, Guoliang Tao, Lei Wu, Xiaobo Wang, Joe Ouyang, Charina Schmitigal, Jing Cheng, Jia Xu
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Publication number: 20160040232Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.Type: ApplicationFiled: March 2, 2015Publication date: February 11, 2016Applicant: AVIVA BIOSCIENCES CORPORATIONInventors: Ping LIN, Douglas T. YAMANISHI, George WALKER, Junquan XU, Mingxian HUANG, Guoliang TAO, Lei WU, Xiaobo WANG, Joe OUYANG, Jing CHENG, Jia XU
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Publication number: 20150185184Abstract: The present invention provides a filtration chamber comprising a microfabricated filter enclosed in a housing, wherein the surface of said filter and/or the inner surface of said housing are modified by vapor deposition, sublimation, vapor-phase surface reaction, or particle sputtering to produce a uniform coating; and a method for separating cells of a fluid sample, comprising: a) dispensing a fluid sample into the filtration chamber disclosed herein; and b) providing fluid flow of the fluid sample through the filtration chamber, wherein components of the fluid sample flow through or are retained by the filter based on the size, shape, or deformability of the components.Type: ApplicationFiled: July 5, 2013Publication date: July 2, 2015Inventors: Antonio Guia, Douglas T. Yamanishi, Andrea Ghetti, Guoliang Tao, Huimin Tao, Ky Truong, Lei Wu, Xiaobo Wang
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Patent number: 8986944Abstract: The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.Type: GrantFiled: August 2, 2006Date of Patent: March 24, 2015Assignee: Aviva Biosciences CorporationInventors: Douglas T. Yamanishi, Paul G. Hujsak, Sara F. Snyder, George Walker, Junquan Xu, Mingxian Huang, Guoliang Tao, Lei Wu, Xiaobo Wang, Joe Ouyang, Charina Schmitigal, Jing Cheng, Jia Xu
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Patent number: 8986945Abstract: Provided are methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells, particularly including debulking that uses a microfabricated filter for filtering samples. The enriched rare cells can be used in a downstream process such as identification, characterization or growth in culture, or in other ways. Also included is a method of determining tumor aggressiveness or the number or proportion of cancer cells in the enriched sample by detecting telomerase activity, nucleic acid or expression after enrichment of rare cells. Also provided is an efficient, rapid method to specifically remove red and white blood cells from a biological sample containing at least one of the cell types, leading to enrichment of rare target cells including circulating tumor (CTC), stromal, mesenchymal, endothelial, fetal, stem, or non-hematopoietic cells et cetera from a blood sample.Type: GrantFiled: August 20, 2007Date of Patent: March 24, 2015Assignee: Aviva Biosciences CorporationInventors: Ping Lin, Andrea Ghetti, Wenge Shi, Mengjia Tang, Gioulnar I. Harvie, Huimin Tao, Guoliang Tao, Lei Wu, David Cerny, Jia Xu, Douglas T. Yamanishi
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Publication number: 20150079677Abstract: The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.Type: ApplicationFiled: May 28, 2014Publication date: March 19, 2015Applicant: AVIVA BIOSCIENCES CORPORATIONInventors: Douglas T. YAMANISHI, Paul G. HUJSAK, Sara F. SNYDER, George WALKER, Junquan XU, Mingxian HUANG, Guoliang TAO, Lei WU, Xiaobo WANG, Joe OUYANG, Charina SCHMITIGAL, Jing CHENG, Jia XU
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Patent number: 8980568Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.Type: GrantFiled: October 31, 2005Date of Patent: March 17, 2015Assignee: Aviva Biosciences CorporationInventors: Ping Lin, Douglas T. Yamanishi, Paul G. Hujsak, Sara F. Snyder, George Walker, Junquan Xu, Mingxian Huang, Guoliang Tao, Lei Wu, Xiaobo Wang, Joe Ouyang, Charina Schmitigal, Jing Cheng, Elizabeth Kwok, Jia Xu
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Patent number: 8969021Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.Type: GrantFiled: September 13, 2013Date of Patent: March 3, 2015Assignee: AVIVA Biosciences CorporationInventors: Ping Lin, Douglas T. Yamanishi, George Walker, Junquan Xu, Mingxian Huang, Guoliang Tao, Lei Wu, Xiaobo Wang, Joe Ouyang, Jing Cheng, Jia Xu
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Publication number: 20140073536Abstract: The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell.Type: ApplicationFiled: September 13, 2013Publication date: March 13, 2014Inventors: Ping LIN, Douglas T. YAMANISHI, George WALKER, Junquan XU, Mingxian HUANG, Guoliang TAO, Lei WU, Xiaobo WANG, Joe OUYANG, Jing CHENG, Jia XU
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Publication number: 20140008210Abstract: The present invention provides a filtration chamber comprising a microfabricated filter enclosed in a housing, wherein the surface of said filter and/or the inner surface of said housing are modified by vapor deposition, sublimation, vapor-phase surface reaction, or particle sputtering to produce a uniform coating; and a method for separating cells of a fluid sample, comprising: a) dispensing a fluid sample into the filtration chamber disclosed herein; and b) providing fluid flow of the fluid sample through the filtration chamber, wherein components of the fluid sample flow through or are retained by the filter based on the size, shape, or deformability of the components.Type: ApplicationFiled: March 15, 2013Publication date: January 9, 2014Inventors: Antonio GUIA, Douglas T. YAMANISHI, Andrea GHETTI, Guoliang TAO, Huimin TAO, Ky TRUONG, Lei WU, Xiaobo WANG