Abstract: A method of validating a regulated application by generating, on a local data processing system, an automated agent to oversee a validation process of the regulated application on the local data processing system regardless of a local or web-based nature of the regulated application.

Abstract: A chronic wound management apparatus fitted to at least some teeth of a patient's upper or lower arch is provided for the application of medications to the teeth and to adjacent gum tissue and for compression of said tissue for treatment of a chronic wound of the periodontal tissue. The apparatus includes at least one recess formed to conform to the teeth. A seal surrounds the recess at a location corresponding to the patient's gum line for applying pressure at the patient's gum line when the patient's teeth are disposed in the recess. A wound compression extension extends from the seal. Methods for treating chronic wounds of the periodontal tissue and for making the apparatus are also disclosed.

Abstract: Method of treating oral subgingival biofilms having obligate anaerobes, facultative anaerobes, aerobic bacteria and other micro-organisms (collectively oral pathogens) associated with certain systemic diseases present within a subgingival biofilm having proteins and amino acids, the steps including providing a periodontal medicament delivery tray having a seal against a patient's adjacent gums containing the oral biofilms with the systemic disease, said seal formed so as to have no contact with teeth, applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent, removing the imbedded oral pathogens from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; repeatedly administering colloidal hydrogen peroxide gel to the gingival tissue following the removing; and following each administering cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel fo

Abstract: A medicament delivery tray and method of manufacture thereof for treating periodontal disease include an apparatus having a body formed to be fitted about all of the upper or lower teeth of a patient and having a top portion and an outer wall and an inner wall with each composed of resilient elastomeric material for substantially conforming to the enclosed teeth and gum tissue proximate to the teeth, the body having recesses, a treatment chamber and a raised seal formed about an inner surface of one of the skirts along a gum line and forming a substantially air tight seal thereto, and a port positioned on one of the skirts to receive a positive pressure from an external pressure source increasing a biasing force of the raised seal against the gum line when positive pressure is received through the port for sealing the chamber.

Abstract: A method of manufacturing an oral appliance for treating sleep apnea of a patient that has a monolithic body with an upper tray with an upper recess formed to conform to the maxillary teeth of the patient and a lower tray with a lower recess formed to conform to the mandibular teeth, the monolithic body defining a coupling of a rear portion of the upper tray to a rear portion of the lower tray at an angle forming a orifice between front mandibular teeth and front maxillary teeth.

Abstract: Method of treating oral subgingival biofilms having obligate anaerobes, facultative anaerobes, aerobic bacteria and other micro-organisms (collectively oral pathogens) associated with certain systemic diseases present within a subgingival biofilm having proteins and amino acids, the steps including providing a periodontal medicament delivery tray having a seal against a patient's adjacent gums containing the oral biofilms with the systemic disease, said seal formed so as to have no contact with teeth, applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent, removing the imbedded oral pathogens from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; repeatedly administering colloidal hydrogen peroxide gel to the gingival tissue following the removing; and following each administering cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel fo

Abstract: Methods and systems for reducing an identified systemic inflammatory marker associated with cardiovascular disease in a patient is provided through periodontal treatment that includes identifying an oral periopathogen related to the systemic inflammatory marker and a biofilm and an environment associated with the periopathogen, preparing a periodontal tray for direct application of a selected medicament having a efficacy in regard to the identified oral periopathogen and biofilm of the gum tissue associated with the one application region in which the medicament is to be placed and applying the tray with the placed selected medicament to the treatment region of the patient such that at least a portion of the selected medicament is forced into a gingival sulcus or periodontal pocket of the gum tissue of the treatment region and monitoring and continuing treatment to reduce the identified systemic inflammatory marker.

Abstract: Methods for treating systemic disease in oral biofilms having a facultative anaerobic bacteria pathogen present including providing a periodontal medicament delivery tray having a seal against a patient's adjacent gums containing the oral biofilms with the systemic disease, said seal formed so as to have no contact with teeth, applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent, removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; repeatedly administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria; and following each administering cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic to aerobic.

Abstract: Assemblies and apparatus for supporting gum tissue during and after periodontal surgery using a tray having a body with a buccal wall, a lingual wall, a tooth covering portion forming a cavity defining internal recesses for the enclosed teeth, in one embodiment a raised seal formed longitudinally on an inner surface of one of the walls along its gum line and applying a biasing pressure thereto to support and stabilize the gum tissue to prevent deflection and alteration, the opposing wall extends substantially from the exposed portion of the tooth to enclose a spaced apart portion of the corresponding gum tissue therefrom and a contoured cavity extends outward from the gum tissue along the gum line forming a medicament holding chamber between an inner surface of the opposing wall and its corresponding gum tissue.

Abstract: Methods for treating systemic disease in oral biofilms having a facultative anaerobic bacteria pathogen present including providing a periodontal medicament delivery tray having a seal against a patient's adjacent gums containing the oral biofilms with the systemic disease, said seal formed so as to have no contact with teeth, applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent, removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; repeatedly administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria; and following each administering cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic to aerobic.

Abstract: Systems and methods for treating gingival tissue or oral biofilm includes applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent; removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria; and cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic (diseased) to aerobic (healthy).

Abstract: Methods and systems for treating and controlling oral periopathogens that have been found to be associated with systemic inflammation and/or disease in a periodontal pocket, inhibiting their entry into the host circulatory system, and decreasing the systemic effects. A bacterial community present in one or more oral treatment regions is determined. A periodontal medicament delivery tray is prepared for the patient with the delivery tray being configured with one or more application regions, each configured for applying a medicament to a different one of the oral treatment regions. The medicaments are applied to each oral treatment region, including placing each medicament into a different application region of the delivery tray. Each of the applied medicaments is applied as a function of a determined efficacy of the medicament against the bacterial community determined to be in the oral treatment region associated with the application region in which each medicament is applied.

Abstract: A system and method of initiating alveolar bone regrowth about a tooth of a patient suffering from bone loss due to periodontal disease that includes topically administering to a periodontal pocket about the tooth of the patient a hydrogen peroxide solution and topically administering to the periodontal pocket about the tooth a medicament that can help manage/control osteogenic activity.

Abstract: A medicament delivery tray and method for treating periodontal disease include fitting of a tray about the teeth and gums wherein the tray includes a seal that creates a substantially airtight seal against the gum line and a substantially airtight treatment chamber about the enclosed teeth and gums, the tray further having a reinforcing skirt providing a biasing force to the seal wherein a positive pressure can be created in the treatment chamber for forcing a medicament into the gums about the enclosed teeth.

Abstract: A method of manufacturing an oral appliance for treating sleep apnea of a patient that has a monolithic body with an upper tray with an upper recess formed to conform to the maxillary teeth of the patient and a lower tray with a lower recess formed to conform to the mandibular teeth, the monolithic body defining a coupling of a rear portion of the upper tray to a rear portion of the lower tray at an angle forming a orifice between front mandibular teeth and front maxillary teeth.

Abstract: An oral appliance for treating sleep apnea of a patient including a monolithic body having an upper tray with an upper recess formed to conform to the maxillary teeth of the patient and a lower tray having a lower recess formed to conform to the mandibular teeth, the monolithic body defining a coupling of a rear portion of the upper tray to a rear portion of the lower tray at an angle forming a orifice between front mandibular teeth and front maxillary teeth, the upper tray including a raised upper seal surrounding the recess corresponding to the patient's upper gum line and the lower tray including a raised lower seal surrounding the recess corresponding to the patient's lower gum line each when the patient's teeth are disposed in the recesses.

Abstract: A medicament delivery tray and method for treating periodontal disease include fitting of a tray about the teeth and gums wherein the tray includes a seal that creates a substantially airtight seal against the gumline and a substantially airtight treatment chamber about the enclosed teeth and gums, the tray further having a reinforcing skirt providing a biasing force to the seal wherein a positive pressure can be created in the treatment chamber for forcing a medicament into the gums about the enclosed teeth.

Abstract: A medicament delivery tray and method for treating periodontal disease include fitting of a tray about the teeth and gums wherein the tray includes a seal that creates a substantially airtight seal against the gumline and a substantially airtight treatment chamber about the enclosed teeth and gums, the tray further having a reinforcing skirt providing a biasing force to the seal wherein a positive pressure can be created in the treatment chamber for forcing a medicament into the gums about the enclosed teeth.

Abstract: Systems and methods for treating gingival tissue or oral biofilm includes applying to the gingival tissue (sulcus or periodontal pocket) a biofilm penetrating antimicrobial agent; removing the imbedded anaerobic bacteria from the gingival tissue following at least one applying of the antimicrobial agent to the gingival tissue; administering colloidal hydrogen peroxide gel to the gingival tissue following the removing of imbedded anaerobic bacteria; and cleaning the gingival tissue with a cleaning agent directly following the administering of the colloidal hydrogen peroxide gel for modifying the environment from anaerobic (diseased) to aerobic (healthy).

Abstract: Methods and systems for treating and controlling oral periopathogens that have been found to be associated with systemic inflammation and/or disease in a periodontal pocket, inhibiting their entry into the host circulatory system, and decreasing the systemic effects. A bacterial community present in one or more oral treatment regions is determined. A periodontal medicament delivery tray is prepared for the patient with the delivery tray being configured with one or more application regions, each configured for applying a medicament to a different one of the oral treatment regions. The medicaments are applied to each oral treatment region, including placing each medicament into a different application region of the delivery tray. Each of the applied medicaments is applied as a function of a determined efficacy of the medicament against the bacterial community determined to be in the oral treatment region associated with the application region in which each medicament is applied.