Abstract: Described herein are compounds that can arrest mitotic cells and their use in the treatment of disorders such as cancers.

Abstract: In certain aspects, disclosed herein are methods of treating cancer in a subject, comprising administration to the subject of (1) one or more glucocorticoid receptor agonists and (2) one or more inhibitors of calcineurin. In some embodiments, the administration of the one or more glucocorticoid receptor agonists and the one or more inhibitors of calcineurin results in restoration of contact inhibition, increased formation of intercellular junctions, reduced cell proliferation, and/or increased vacuolization of cells growing in multilayer zones. Included herein are methods for identification of novel compounds that restore contact inhibition in cancer cells.

Abstract: A high anti-interference microsystem based on System In Package (SIP) for a power grid is provided. The high anti-interference microsystem comprises a ceramic cavity, a ceramic substrate, a magnetic cover plate, a digital signal processing circuit, an analog signal conditioning circuit and a shield, wherein the ceramic cavity supports the ceramic substrate, the magnetic cover plate is in sealed contact with the ceramic cavity, and the ceramic substrate is arranged in a cavity formed by the ceramic cavity and the magnetic cover plate; a sealed shell of the microsystem based on SIP is composed of the magnetic cover plate and the ceramic cavity; the digital signal processing circuit and the analog signal conditioning circuit are arranged on the ceramic substrate and respectively process received signals to be processed; the shield covers an outer side of the sealed shell and is used for shielding external magnetic field interference.

Abstract: An alumina-based ceramic tool material with low thermal expansion and a preparation process thereof, accordingly, the ceramic tool material may have both the high hardness of alumina ceramics after the hot pressing sintering, and reduces the thermal expansion coefficient of the overall ceramic material by adding the Sc2W3O12 as the negative thermal expansion phase, which improves the thermal shock resistance of ceramic tools in high-speed cutting engineering and meets the requirements of large temperature range during the machining of nickel-based superalloys. Moreover, the composite material does not use metal binder and has strong thermal stability even in the high-speed machining under extreme heat-force-chemistry coupling, so it has a high machining compatibility for nickel-based superalloys.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: A radiation emission device is provided. The radiation emission device may include an anode, a first cathode, a heating device and an enclosure. The first cathode may include a first filament that emit an electron beam striking the anode to generate radioactive rays for imaging. The heating device may be located outside of the first cathode and be configured to warm up the anode. The enclosure may be configured to enclosure the first cathode and the anode.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: A radiation emission device is provided. The radiation emission device may include an anode, a first cathode, a heating device and an enclosure. The first cathode may include a first filament that emit an electron beam striking the anode to generate radioactive rays for imaging. The heating device may be located outside of the first cathode and be configured to warm up the anode. The enclosure may be configured to enclosure the first cathode and the anode.

Abstract: A radiation emission device is provided. The radiation emission device may include a cathode configured to emit an electron beam and an anode configured to rotate on a shaft. The anode may be situated to receive the electron beam from the cathode. The radiation emission device may further include a rotor configured to drive the anode to rotate. The rotor may be mechanically connected to the shaft. The radiation emission device may further include a sleeve configured to support the shaft via at least one bearing. The cathode, the anode, and the rotor may be enclosed in an enclosure that is connected to the sleeve. At least a portion of the sleeve may reside outside the enclosure.

Abstract: The disclosure discloses a door lock including a locking mechanism, a power interface, a main control board, an environmental information collection device and a power supply management device, where the locking mechanism, power interface and power supply management device are respectively connected with the main control board, the environmental information collection device connected with the power supply management device, the environmental information collection device configured to collect and transmit environmental information on the surrounding of the door lock to the power supply management device; the power supply management device configured to carry out processing according to the environmental information and output a power supply mode matched with the environmental information to the main control board; and the power interface configured to execute an operation related to the power supply mode matched with the environmental information according to a power supply instruction from the main control

Abstract: The disclosure discloses a door lock including a locking mechanism, a power interface, a main control board, an environmental information collection device and a power supply management device, where the locking mechanism, power interface and power supply management device are respectively connected with the main control board, the environmental information collection device connected with the power supply management device, the environmental information collection device configured to collect and transmit environmental information on the surrounding of the door lock to the power supply management device; the power supply management device configured to carry out processing according to the environmental information and output a power supply mode matched with the environmental information to the main control board; and the power interface configured to execute an operation related to the power supply mode matched with the environmental information according to a power supply instruction from the main control

Abstract: The disclosure discloses a door lock including a locking mechanism, a power interface, a main control board, an environmental information collection device and a power supply management device, where the locking mechanism, power interface and power supply management device are respectively connected with the main control board, the environmental information collection device connected with the power supply management device, the environmental information collection device configured to collect and transmit environmental information on the surrounding of the door lock to the power supply management device; the power supply management device configured to carry out processing according to the environmental information and output a power supply mode matched with the environmental information to the main control board; and the power interface configured to execute an operation related to the power supply mode matched with the environmental information according to a power supply instruction from the main control

Abstract: Described herein are one or more implementations for electromagnetic tracking of position and orientation that utilizes a discretized numerical field model, rather than the conventional analytical dipole model.