Patents by Inventor E-Chiang Lee

E-Chiang Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression vector production and high-throughput cell screening
    Patent number: 10337000
    Abstract: The present invention relates inter alia to expression vector production as well as application to the production of host cells for protein repertoire expression and high-throughput screening. The invention also relates to primers useful for PCR amplification of nucleotide sequences encoding human antibody variable domains.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: July 2, 2019
    Assignee: KYMAB LIMITED
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Hui Liu, Andrew Wood, Vivian Wong
  • Animal Models and Therapeutic Molecules
    Publication number: 20190174729
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 13, 2019
    Inventors: E-Chiang Lee, Jasper Clube, Allan Bradley
  • Animal models and therapeutic molecules
    Patent number: 10226033
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: March 12, 2019
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang, Dominik Spensberger, Hui Liu, Jasper Clube
  • Animal models and therapeutic molecules
    Patent number: 10165763
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: January 1, 2019
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang
  • Animal models and therapeutic molecules
    Patent number: 10149462
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: December 11, 2018
    Assignee: Kymab Limited
    Inventors: E-Chiang Lee, Jasper Clube, Allan Bradley
  • ANIMAL MODELS AND THERAPEUTIC MOLECULES
    Publication number: 20180298112
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Application
    Filed: April 9, 2018
    Publication date: October 18, 2018
    Inventors: Allan BRADLEY, E-Chiang LEE, Wei WANG, Dominik SPENSBERGER, Hui LIU, Jasper CLUBE, Qi LIANG
  • Transgenic Animals
    Publication number: 20180295821
    Abstract: The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous antibody chain expression has been inactivated.
    Type: Application
    Filed: April 17, 2018
    Publication date: October 18, 2018
    Inventors: Glenn FRIEDRICH, E-Chiang LEE
  • Chimaeric Surrogate Light Chains (SLC) Comprising Human VpreB
    Publication number: 20180282761
    Abstract: The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting.
    Type: Application
    Filed: May 7, 2018
    Publication date: October 4, 2018
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Dominik SPENSBERGER, Nicholas ENGLAND
  • Animal models and therapeutic molecules
    Patent number: 10064398
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: September 4, 2018
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang, Glenn Friedrich
  • Chimaeric surrogate light chains (SLC) comprising human VpreB
    Patent number: 9963716
    Abstract: The present invention relates inter alia to improvements in the production of chimaeric antibodies in non-human transgenic vertebrates such as mice and rats bearing one or more chimaeric antibody transgenes. In particular, the invention provides for improved non-human vertebrates and cells in which VpreB has been species-matched with the variable region of the chimaeric antibodies. Also, embodiments also provide for species-matching of the entire surrogate light chain for efficient pairing with chimaeric heavy chains during B-cell development in vivo in a non-human transgenic vertebrate setting.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: May 8, 2018
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Dominik Spensberger, Nicholas England
  • Anti-ICOS antibodies
    Patent number: 9957323
    Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: May 1, 2018
    Assignee: Kymab Limited
    Inventors: Richard Charles Alfred Sainson, Stephen John Arkinstall, Jamie Iain Campbell, Mohammed Hanif Ali, E-Chiang Lee, Matthew John McCourt, Nikole Sandy, Cassandra Van Krinks, Volker Germaschewski, Ian Kirby, Miha Kosmac, Thomas Gallagher, Cecilia Deantonio, Stephen D. Gillies
  • Animal models and therapeutic molecules
    Patent number: 9938357
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: April 10, 2018
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Wei Wang, Qi Liang, Dominik Spensberger, Hui Liu, Jasper Clube
  • Animal models and therapeutic molecules
    Patent number: 9938358
    Abstract: The invention discloses methods for the generation of chimaeric human non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: April 10, 2018
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Wei Wang, Qi Liang, Dominik Spensberger, Hui Liu, Jasper Clube
  • Animal models and therapeutic molecules
    Patent number: 9924705
    Abstract: The invention discloses methods for the generation of chimaeric human- non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: March 27, 2018
    Assignee: Kymab Limited
    Inventors: Qi Liang, Allan Bradley, E-Chiang Lee, Wei Wang, Dominik Spensberger, Hui Liu, Jasper Clube
  • ANTI-ICOS ANTIBODIES
    Publication number: 20180066058
    Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.
    Type: Application
    Filed: September 7, 2017
    Publication date: March 8, 2018
    Inventors: Richard Charles Alfred SAINSON, Stephen John ARKINSTALL, Jamie Iain CAMPBELL, Mohammed Hanif ALI, E-Chiang LEE, Matthew John MCCOURT, Nikole SANDY, Cassandra VAN KRINKS, Volker GERMASCHEWSKI, Ian KIRBY, Miha KOSMAC, Thomas GALLAGHER, Cecilia DEANTONIO, Stephen D. GILLIES
  • Animal models and therapeutic molecules
    Patent number: 9896516
    Abstract: The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanized antibodies; compositions comprising these fully humanized antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in these methods.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: February 20, 2018
    Assignee: Kymab Limited
    Inventors: Allan Bradley, E-Chiang Lee, Qi Liang, Wei Wang, Dominik Spensberger, Hui Liu, Jasper Clube
  • ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE
    Publication number: 20180030121
    Abstract: The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention.
    Type: Application
    Filed: October 17, 2017
    Publication date: February 1, 2018
    Inventors: Allan BRADLEY, Glenn FRIEDRICH, E-Chiang LEE, Mark STRIVENS, Nicholas ENGLAND
  • Animal Models and Therapeutic Molecules
    Publication number: 20170354131
    Abstract: The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the methods.
    Type: Application
    Filed: August 29, 2017
    Publication date: December 14, 2017
    Inventors: Allan BRADLEY, E-Chiang LEE, Qi LIANG, Wei WANG, Dominik SPENSBERGER, Hui LIU, Jasper CLUBE
  • ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE
    Publication number: 20170320936
    Abstract: The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention.
    Type: Application
    Filed: July 21, 2017
    Publication date: November 9, 2017
    Inventors: Allan Bradley, Glenn Friedrich, E-Chiang Lee, Mark Strivens, Nicholas England
  • SELECTIVE NAV PROTEIN BINDERS
    Publication number: 20170306013
    Abstract: The invention provides antibodies and fragments thereof which bind to human Nav1.7, as well as nucleic acids, vectors, host cells and hybridomas for making the same. Further provided are pharmaceutical compositions for use in treating, preventing and/or reducing the risk of a NAV1.7-mediated conditions or diseases, such as pain, inflammation, and metabolic/chronic diseases. The invention additionally provides methods of generating an antibody against a NAV protein of interest.
    Type: Application
    Filed: October 20, 2015
    Publication date: October 26, 2017
    Applicant: Kymab Limited
    Inventors: Nigel Clark, E-Chiang Lee