Patents by Inventor Eberhard Ehlers
Eberhard Ehlers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7785826Abstract: The invention relates to a method for the enzymatic elimination of the N-acyl side chain from lipopeptides to form the corresponding nucleus, wherein the lipopeptide is prepared by fermentation, the lipopeptide being bound to the cells of the biomass, and the biomass is removed with the adhering lipopeptide, the biomass with the adhering lipopeptide is resuspended in an aqueous system, a suitable deacylase is added in dissolved or solid form to the suspension of the biomass, and the corresponding nucleus is formed, and the nucleus is optionally isolated and purified, wherein the lipopeptide obtained by fermentation is reacted after the end of the fermentation as cell-bound biomass without further purification directly with a deacylase, whereby the N-acyl chain linked via an amide linkage is eliminated.Type: GrantFiled: June 5, 2007Date of Patent: August 31, 2010Assignee: Sanofi-Aventis Deutschland GmbHInventors: Eberhard Ehlers, Heinrich Decker, Sebastian Rissom, Guido Seidel, Reiner Olliger
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Publication number: 20080076149Abstract: The invention relates to a method for the enzymatic elimination of the N-acyl side chain from lipopeptides to form the corresponding nucleus, wherein the lipopeptide is prepared by fermentation, the lipopeptide being bound to the cells of the biomass, and the biomass is removed with the adhering lipopeptide, the biomass with the adhering lipopeptide is resuspended in an aqueous system, a suitable deacylase is added in dissolved or solid form to the suspension of the biomass, and the corresponding nucleus is formed, and the nucleus is optionally isolated and purified, wherein the lipopeptide obtained by fermentation is reacted after the end of the fermentation as cell-bound biomass without further purification directly with a deacylase, whereby the N-acyl chain linked via an amide linkage is eliminated.Type: ApplicationFiled: June 5, 2007Publication date: March 27, 2008Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBHInventors: Eberhard EHLERS, Heinrich DECKER, Sebastian RISSOM, Guido SEIDEL, Reiner OLLIGER
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Patent number: 6624143Abstract: The invention relates to a calcium salt of the compound of formula (II), where R1 is a straight-chain or branched, saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which can optionally be interrupted by or linked to one or more phenyl or cycloalkyl groups and optionally interrupted by oxygen. The invention also relates to a method for producing said calcium salt and to its use as a medicine.Type: GrantFiled: August 25, 2000Date of Patent: September 23, 2003Assignee: Aventis Pharma Deutschland GmbHInventors: Laszló Vértesy, Werner Aretz, Heinrich Decker, Eberhard Ehlers, Michael Kurz, Frank Rainer Schmidt
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Patent number: 5986089Abstract: Moenomycin A can be prepared by fermentation of a moenomycin-producing microorganism and subsequent separation of moenomycin A from the other components of the culture filtrate by chromatography, using an anion exchanger as chromatography material.Type: GrantFiled: April 16, 1998Date of Patent: November 16, 1999Assignee: Hoechst AktiengesellschaftInventors: Laszlo Vertesy, Andreas Stark, Eberhard Ehlers
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Patent number: 5710146Abstract: Cephem derivatives of the general formula ##STR1## in which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.Type: GrantFiled: July 22, 1994Date of Patent: January 20, 1998Assignee: Hoechst AktiengesellschaftInventors: Walter Durckheimer, Dieter Bormann, Eberhard Ehlers, Elmar Schrinner, Rene Heymes
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Patent number: 5316929Abstract: The invention relates to a process for the preparation of MA, which ensures MA production by enzymatic catalysis in glycine/NaOH buffer, and by the use of a phosphate-containing culture medium for Bacillus sp. DSM 4675 and by extraction of the biomass with acetone.Type: GrantFiled: August 11, 1993Date of Patent: May 31, 1994Assignee: Hoechst AktiengesellschaftInventors: Werner Aretz, Eberhard Ehlers, Udo Hedtmann
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Patent number: 5089490Abstract: Cephem derivatives of the general formula ##STR1## in which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.Type: GrantFiled: August 23, 1990Date of Patent: February 18, 1992Assignee: Hoechst AktiengesellschaftInventors: Walter Durckheimer, Dieter Bormann, Eberhard Ehlers, Elmar Schrinner, Rene Heymes
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Patent number: 4758556Abstract: Cephem derivatives of the general formula ##STR1## in which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.Type: GrantFiled: March 30, 1978Date of Patent: July 19, 1988Assignee: Hoechst AktiengesellschaftInventors: Walter Durckheimer, Dieter Bormann, Eberhard Ehlers, Elmar Schrinner, Rene Heymes
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Patent number: 4454129Abstract: What are disclosed are cephem compounds of the formula ##STR1## useful for combating bacterial infections, and methods of making and using the same.Type: GrantFiled: April 30, 1982Date of Patent: June 12, 1984Assignee: Hoechst AktiengesellschaftInventors: Burkhard Mencke, Eberhard Ehlers, Jurgen Blumbach, Walter Durckheimer, Karl Seeger
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Patent number: 4399131Abstract: What are disclosed are cephem compounds of the formula ##STR1## in which R.sub.1 denotes hydrogen, an optionally substituted alkyl, acyl, arylsulfonyl or alkylsulfonyl group or an amino-protective group which is known from peptide chemistry, R.sub.2 denotes hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, acyl, aryl, arylsulfonyl, alkylsulfonyl or heterocyclic group, R.sub.3 denotes hydrogen, an ester group or a cation, R.sub.4 denotes hydrogen, a lower alkoxy group or a group which can be converted to this, X denotes a SO group in the R or S configuration or a SO.sub.2 group and A denotes hydrogen, an optionally substituted alkoxy or alkenyloxy group, halogen or a group --CH.sub.2 Y, in which Y represents hydrogen, halogen or the radical of a nucleophilic compound, and in which the R.sub.Type: GrantFiled: May 5, 1980Date of Patent: August 16, 1983Assignee: Hoechst AGInventors: Walter Durckheimer, Eberhard Ehlers, Hubert Seliger, Elmar Schrinner
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Patent number: 4278793Abstract: Cephem derivatives of the general formula ##STR1## in which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.Type: GrantFiled: July 21, 1980Date of Patent: July 14, 1981Assignee: Hoechst AktiengesellschaftInventors: Walter Durckheimer, Dieter Bormann, Eberhard Ehlers, Elmar Schrinner, Rene Heymes
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Patent number: RE35754Abstract: Cephem derivatives of the general formula ##STR1## is which the R.sub.2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.Type: GrantFiled: July 11, 1990Date of Patent: March 24, 1998Assignee: Hoechst AktiengesellschaftInventors: Walter Durckheimer, Dieter Bormann, Eberhard Ehlers, Elmar Schrinner, Rene Heymes