Patents by Inventor Ecevit Bilgili
Ecevit Bilgili has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10646452Abstract: The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process.Type: GrantFiled: March 17, 2014Date of Patent: May 12, 2020Assignees: New Jersey Institute of Technology, Rutgers, The State University of New JerseyInventors: Rajesh N. Dave, Ramani Susarla, Boris Khusid, Anagha A. Bhakay, Ecevit A. Bilgili, Fernando Muzzio
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Patent number: 9931300Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.Type: GrantFiled: August 12, 2016Date of Patent: April 3, 2018Assignee: NEW JERSEY INSTITUTE OF TECHNOLOGYInventors: Ecevit Bilgili, Rajesh Dave, Anagha Bhakay, Mohammad Azad
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Patent number: 9801820Abstract: A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.Type: GrantFiled: November 8, 2013Date of Patent: October 31, 2017Assignee: NEW JERSEY INSTITUTE OF TECHNOLOGYInventors: Daniel To, Rajesh Dave, Catharina Knieke, Ecevit A. Bilgili, Mohammed A. Azad
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Publication number: 20160346209Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.Type: ApplicationFiled: August 12, 2016Publication date: December 1, 2016Applicant: New Jersey Institute of TechnologyInventors: Ecevit Bilgili, Rajesh Dave, Anagha Bhakay, Mohammad Azad
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Patent number: 9452107Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.Type: GrantFiled: March 14, 2013Date of Patent: September 27, 2016Assignee: New Jersey Institute of TechnologyInventors: Ecevit Bilgili, Rajesh Dave, Anagha Bhakay, Mohammad Azad
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Publication number: 20160022599Abstract: The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process.Type: ApplicationFiled: March 17, 2014Publication date: January 28, 2016Applicant: NEW JERSEY INSTITUTE OF TECHNOLOGYInventors: Rajesh N. Dave, Ramani Susarla, Boris Khusid, Anagha A. Bhakay, Ecevit A. Bilgili, Fernando Muzzio
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Publication number: 20150297521Abstract: A composite particle including a core with at least one carrier material; a fluidizing material layer on the surface of the core; and an outer layer comprising nanoparticles of an ingestible material distributed in at least one matrix-forming material. A process of making the composite particles includes the steps of dry coating carrier particles with a fluidizing material; preparing a suspension of nanoparticles of an ingestible material distributed in a matrix-forming material; and fluid bed coating the carrier particles with the suspension. The process and products provide quick dissolving composite particles which can be used for delivery of poorly water soluble ingestible materials in suitable dosage forms. The process of the invention reduces or prevents particle agglomeration during fabrication of the composite particles to enable delivery and quick redispersion of nanoparticles of the ingestible material from a dosage form.Type: ApplicationFiled: November 8, 2013Publication date: October 22, 2015Applicant: New Jersey Institute of TechnologyInventors: Daniel To, Rajesh Dave, Catharina Knieke, Ecevit A. Bilgili, Mohammed A. Azad
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Publication number: 20130295190Abstract: The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g.Type: ApplicationFiled: March 14, 2013Publication date: November 7, 2013Applicant: New Jersey Institute of TechnologyInventors: Ecevit Bilgili, Rajesh Dave, Anagha Bhakay, Mohammad Azad
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Patent number: 6513737Abstract: An apparatus and process for pulverization of polymeric material having a multi-component screw disposed within an elongated cylindrical housing. The multi-component screw has an independently rotatable extrusion portion and an independently rotatable pulverization portion. A cooling means is provided to maintain the fine powder material produced during the pulverization process at a desired temperature. In one embodiment of this invention, a second multi-component screw having an independently rotatable extrusion portion and an independently rotatable pulverization portion is disposed within the elongated cylindrical housing.Type: GrantFiled: March 9, 2001Date of Patent: February 4, 2003Assignee: Illinois Institute of TechnologyInventors: George K. Ivanov, Hamid Arastoopour, Ecevit Bilgili, Nima Shahidi, Barry Bernstein
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Publication number: 20020125352Abstract: An apparatus and process for pulverization of polymeric material having a multi-component screw disposed within an elongated cylindrical housing. The multi-component screw has an independently rotatable extrusion portion and an independently rotatable pulverization portion. A cooling means is provided to maintain the fine powder material produced during the pulverization process at a desired temperature. In one embodiment of this invention, a second multi-component screw having an independently rotatable extrusion portion and an independently rotatable pulverization portion is disposed within the elongated cylindrical housing.Type: ApplicationFiled: March 9, 2001Publication date: September 12, 2002Inventors: George K. Ivanov, Hamid Arastoopour, Ecevit Bilgili, Nima Shahidi, Barry Bernstein
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Patent number: 5904885Abstract: A process for recycling rubber, elastomers, and thermoset materials in which the material to be recycled is pulverized in a manner which maintains the chemical composition of the material, producing a powder. The powder is introduced into a mold which is heated to a temperature of at least about 200.degree. C. and a compression force of at least about 10 tons is applied to the powder for a period of at least one hour, resulting in formation of a single piece of the rubber, elastomeric, or thermoset material, with no change in chemical structure.Type: GrantFiled: December 4, 1997Date of Patent: May 18, 1999Assignee: Illinois Institute of TechnologyInventors: Hamid Arastoopour, Daniel A. Schocke, Barry Bernstein, Ecevit Bilgili