Patents by Inventor Eckhard Claus

Eckhard Claus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorosurfactants
    Patent number: 9115062
    Abstract: The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to processes for the preparation of these compounds.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: August 25, 2015
    Assignee: MERCK PATENT GMBH
    Inventors: Wolfgang Hierse, Eckhard Claus, Jan Krause, Melanie Kleineidam, Steffen Schellenberger, Andreas Bathe
  • Pyridopyrazine derivatives and their use
    Patent number: 8937068
    Abstract: Pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: January 20, 2015
    Assignee: Zentaris GmbH
    Inventors: Irene Seipelt, Eckhard Claus, Eckhard Guenther, Tilmann Schuster, Michael Czech, Emmanuel Polymeropoulos
  • Modulating signal transduction pathways with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-B]pyrazine-6-yl]thiourea
    Patent number: 8604196
    Abstract: A method of modulating one or more of ras-Raf-Mek-Erk signal transduction pathway, PI3K-Akt signal transduction pathway and SAPK signal transduction pathway with 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2,3-b]pyrazine-6-yl]thiourea, its geometric isomer, or its tautomer.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: December 10, 2013
    Assignee: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus
  • DERIVATIVES FOR PERFLUOROALKOXY SULFOSUCCINATES AS SURFACTANTS
    Publication number: 20130269568
    Abstract: The present invention relates to novel compounds containing Rf end groups, to the use thereof as surface-active substances, and to processes for the preparation of these compounds. The claimed compounds fall under the following formula: (I), Two examples of claimed compound are: (II), (III).
    Type: Application
    Filed: November 26, 2011
    Publication date: October 17, 2013
    Applicant: MERCK PATENT GmbH
    Inventors: Eckhard Claus, Melanie Kleineidam, Wolfgang Hierse
  • Modulating signal transduction pathways with substituted pyridol [2,3-b] pyrazines
    Patent number: 8536332
    Abstract: Method of modulating ras-Raf-Mek-Erk signal transduction pathway, PI3K-Akt signal transduction pathway and/or SAPK signal transduction pathway with a pyrido[2,3-b]pyrazine of formula (Ia).
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: September 17, 2013
    Assignee: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus
  • Pyridopyrazine derivatives, process of manufacturing and uses thereof
    Patent number: 8507486
    Abstract: 1-ethyl-3-[3-(1-methyl-1H-pyrazol-4-yl)-pyrido[2.3-b]pyrazine-6-yl]thiourea which HAS activity to the modulation of misdirected cellular signal transduction processes such as tyrosine kinases, serine/threonine kinases and/or lipid kinases.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: August 13, 2013
    Assignee: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus
  • NOVEL PYRIDOPYRAZINES AND THEIR USE AS MODULATORS OF KINASES
    Publication number: 20130157976
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: February 19, 2013
    Publication date: June 20, 2013
    Inventors: Eckhard CLAUS, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Michael Czech, Tilmann Schuster
  • Quinoxaline derivatives and their use for treating benign and malignant tumour disorders
    Patent number: 8394801
    Abstract: The invention provides quinoxalines of the general formula I which are used as medicaments preferably for treating tumour disorders, in particular in cases of drug resistance to other active compounds and in cases of metastasic carcinoma. The possible applications are not limited to tumour disorders.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: March 12, 2013
    Assignee: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Tilmann Schuster, Emmanuel Polymeropoulos, Michael Czech, Eckhard Claus
  • NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF
    Publication number: 20120277219
    Abstract: The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: July 5, 2012
    Publication date: November 1, 2012
    Applicant: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus
  • NOVEL PYRIDOPYRAZINES AND THEIR USE AS MODULATORS OF KINASES
    Publication number: 20120252760
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 4, 2012
    Applicant: ZENTARIS GmbH
    Inventors: Eckhard Claus, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Michael Czech, Tilmann Schuster
  • NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF
    Publication number: 20120214768
    Abstract: The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 23, 2012
    Applicant: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus
  • NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF
    Publication number: 20120209050
    Abstract: The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 16, 2012
    Applicant: Aeterna Zentaris GmbH
    Inventors: Matthias GERLACH, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus
  • Pyridopyrazines and their use as modulators of kinases
    Patent number: 8217042
    Abstract: The invention relates to pyrido[2,3-b]pyrazines of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: July 10, 2012
    Assignee: Zentaris GmbH
    Inventors: Eckhard Claus, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Michael Czech, Tilmann Schuster
  • Substituted pyrido[2,3-b]pyrazine compounds as modulators of tyrosine kinases
    Patent number: 8202883
    Abstract: The invention relates to pyrido[2,3-b]pyrazine compounds of formulae (Ia) and (Ib) which have activity to the modulation of misdirected cellular signal transduction processes such as tyrosine kinases, serine/threonine kinases and/or lipid kinases, their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations:
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: June 19, 2012
    Assignee: Aeterna Zentaris GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus
  • Pyridopyrazines and the use thereof as kinase inhibitors
    Patent number: 8193186
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general Formula I, their preparation and use as medicaments, in particular for the treatment of malignant and other disorders based on pathological cell proliferations.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: June 5, 2012
    Assignee: AEterna Zentaris GmbH
    Inventors: Irene Seipelt, Ulf R. Rapp, Ludmilla Wixler, Eckhard Claus, Eckhard Günther
  • FLUOROSURFACTANTS
    Publication number: 20120111233
    Abstract: The present invention relates to novel compounds containing fluorinated end groups, to the use thereof as surface-active substances, and to processes for the preparation of these compounds.
    Type: Application
    Filed: June 1, 2010
    Publication date: May 10, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Wolfgang Hierse, Eckhard Claus, Jan Krause, Melanie Kleineidam, Steffen Schellenberger, Andreas Bathe
  • FLUOROSURFACTANTS
    Publication number: 20110118428
    Abstract: The present invention relates to novel compounds containing CF3O end groups, to the use thereof as surface-active substances, and to processes for the preparation of these compounds.
    Type: Application
    Filed: June 27, 2009
    Publication date: May 19, 2011
    Applicant: Merck Patent Gesellschaft Mit Beschrankterhaftung
    Inventors: Wolfgang Hierse, Eckhard Claus, Melanie Kleineidam, Peer Kirsch, Elvira Montenegro, Martin Seidel
  • FLUOROSURFACTANTS
    Publication number: 20110088594
    Abstract: The present invention relates to compounds of the formulae (I), (II) and (III), to the use of compounds containing at least one perfluoro-tert-butoxy group and at least one substituted or unsubstituted aromatic end group as surface-active agent, and to a process for the preparation of compounds of the formula (II).
    Type: Application
    Filed: May 15, 2009
    Publication date: April 21, 2011
    Inventors: Eckhard Claus, Fanny Schooren, Martin Seidel, Wolfgang Hierse, Peer Kirsch
  • QUINOXALINE DERIVATIVES AND THEIR USE FOR TREATING BENIGN AND MALIGNANT TUMOUR DISORDERS
    Publication number: 20100266538
    Abstract: The invention provides quinoxalines of the general formula I which are used as medicaments preferably for treating tumour disorders, in particular in cases of drug resistance to other active compounds and in cases of metastasic carcinoma. The possible applications are not limited to tumour disorders.
    Type: Application
    Filed: March 25, 2010
    Publication date: October 21, 2010
    Applicant: AETERNA ZENTARIS GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Tilmann Schuster, Emmanuel Polymeropoulos, Michael Czech, Eckhard Claus
  • NOVEL PYRIDOPYRAZINE DERIVATIVES, PROCESS OF MANUFACTURING AND USES THEREOF
    Publication number: 20090275534
    Abstract: The invention relates to pyrido[2,3-b]pyrazine compounds of general formulae (Ia) and (Ib), to their preparation and use, for example, for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: May 9, 2008
    Publication date: November 5, 2009
    Applicant: ZENTARIS GmbH
    Inventors: Matthias Gerlach, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Tilmann Schuster, Eckhard Claus