Patents by Inventor Eddie L. Chang
Eddie L. Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120315624Abstract: As described herein, locked nucleic acids are used with flow cytometric-fluorescence in situ hybridization (LNA flow-FISH) detection of viral RNA in infected cells. This technique represents a straightforward way to monitor viral infection in cells and can be used to measure efficacy of potential antiviral compounds.Type: ApplicationFiled: June 6, 2012Publication date: December 13, 2012Inventors: Eddie L. Chang, Kelly L. Robertson
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Patent number: 7932096Abstract: A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases.Type: GrantFiled: October 6, 2009Date of Patent: April 26, 2011Assignee: The United States of America as represented by the Secretary of the NavyInventors: Sulay Jhaveri, Mario Ancona, Edward E Foos, Eddie L Chang
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Publication number: 20110027388Abstract: Hexaamminecobalt(III) chloride, also called Cohex, reduces the extent of viral infection, including difficult to treat infections caused by Ebola virus and HIV. Disclosed are methods for treating a viral infection, comprising administering to a patient a cobalt(III) hexammine compound in an amount effective to reduce an extent of a viral infection. Also disclosed are kits for delivery of a cobalt(III) hexammine compound by injection.Type: ApplicationFiled: July 30, 2010Publication date: February 3, 2011Applicants: The Government of the US, as represented by the Secretary of the NavyInventors: Eddie L. Chang, Lisa Hensley, Dzung C. Thach, Andy Knight, Gene Olinger
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Publication number: 20100029921Abstract: A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases.Type: ApplicationFiled: October 6, 2009Publication date: February 4, 2010Applicant: The Government of the US, as represented by the Secretary of the NavyInventors: Sulay Jhaveri, Mario Ancona, Edward E. Foos, Eddie L. Chang
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Patent number: 7655474Abstract: A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases.Type: GrantFiled: April 3, 2006Date of Patent: February 2, 2010Assignee: The United States of America as represented by the Secretary of the NavyInventors: Sulay Jhaveri, Mario Ancona, Edward E Foos, Eddie L Chang
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Publication number: 20100004187Abstract: Disclosed herein is a method of: administering to a subject suspected of being infected with a bacterium, a composition of a cobalt (III) compound having the formula CoR1R2R3R4R5R6 or a salt thereof and an antibiotic compound. Each of R1, R2, R3, R4, and R5 is the same or different and includes an N-based ligand donor atom selected from the group consisting of ammonia, primary amine, or secondary amine, or salt thereof. R6 is a ligand. Also disclosed herein is a composition of the above cobalt (III) compound and an antibiotic compound.Type: ApplicationFiled: June 30, 2009Publication date: January 7, 2010Applicant: The Government of the United States of America, as represented by the Secretary of the NavyInventors: Eddie L. Chang, Daniel Zabetakis, Andy Knight, Monique L. van Hoek
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Publication number: 20090269853Abstract: A method of making a nanoclusters functionalized with a single DNA strand comprising the steps of providing nanoclusters, combining said nanoclusters with thiolated DNA, incubating said nanoclusters and thiolated DNA mixture, combining said mixture with a solution comprising ethanol and dichloromethane; separating said mixture into an aqueous phase and an organic phase, mixing said aqueous phase with a solution comprising dicholormethane and NaCl, and separating the mixture into an aqueous phase and an organic phase; wherein said organic phase comprises said nanoclusters functionalized with a single DNA strand. Further, provided is a nanocluster functionalized with a single DNA strand comprising a nanocluster, said nanocluster being functionalized with a single DNA strand, said DNA strand having a length of about 10 to about 50 bases.Type: ApplicationFiled: April 3, 2006Publication date: October 29, 2009Applicant: The Government of the US, as represented by the Secretarty of the NavyInventors: Sulay Jhaveri, Mario Ancona, Edward E. Foos, Eddie L. Chang
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Publication number: 20080182835Abstract: The present invention is generally directed to a method of prophylaxis against viral infection of a cell or subject or a method of treating a subject infected with a virus including administering an antiviral composition having the general Structure III, wherein each of R1, R2, R3, R4, R5 and R6 is the same or different and includes an N-based ligand donor atom selected from the group consisting of ammonia, primary amine or secondary amine, or salt thereof. The present invention is also generally directed to a method of preparing an antiviral agent including providing a cobalt pentammine salt having a non-amine coordination site and mono-substituting the non-amine coordination site with a functional group incorporating a strong coordinator atom to cobalt to form a CoHex structure of Structure III, in which R1 incorporates the functional group having the strong coordinator atom coordinated with the cobalt atom, or a salt thereof.Type: ApplicationFiled: November 2, 2007Publication date: July 31, 2008Applicant: The Government of the US, as represented by the Secretary of the NavyInventors: Eddie L. Chang, James B. Delehanty, Dzung C. Thach, Jason Bongard, Andy Knight
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Publication number: 20030054949Abstract: The present invention relates to the preparation of metal chelate complexes immobilized on a support, immobilized metal chelate complexes and methods of using the supports and immobilized metal chelate complexes for the adsorption and/or hydrolysis of phosphate esters. More specifically, processes for the preparation of immobilized metal chelate complexes by attachment of metal chelate complexes to solids, polymers, micelles, liposomes, tubules and other self-organized polymolecular associations immobilized metal chelate complexes made by such processes and use of the supports and immobilized metal chelate complexes for the adsorption and/or hydrolysis of phosphate ester group containing compounds such as chemical warfare nerve agents and pesticides, are disclosed. The present invention provides the ability to efficiently decontaminate phosphate ester compounds under a wide range of conditions in a practical and cost-effective manner.Type: ApplicationFiled: May 23, 2001Publication date: March 20, 2003Inventors: Eddie L. Chang, Alok Singh, Qin Lu, Christopher Hartshorn
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Patent number: 6297191Abstract: A composition including a solid substrate, a metal chelant, and a saturated hydrocarbon linker attached between the substrate and the chelant, wherein the chelant is an organic wherein the chelant is an organic macrocycle or polyol.Type: GrantFiled: March 22, 2000Date of Patent: October 2, 2001Assignee: The United States of America as represented by the Secretary of the NavyInventors: Dhananjay Puranik, Robert E. Morris, Eddie L. Chang
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Patent number: 6248842Abstract: Selective, crosslinked chelating polymers are produced by substituting an acyclic chelating agent with a polymerizable functional group. The resulting substituted acyclic chelating agent is then complexed with the target metal ion. A crosslinkable monomer is then added and the complexed material is crosslinked. The complexed metal is then removed, providing a crosslinked polymeric chelating agent that has been templated for the target metal ion.Type: GrantFiled: February 25, 1999Date of Patent: June 19, 2001Assignee: The United States of America as represented by the Secretary of the NavyInventors: Alok Singh, Eddie L. Chang
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Patent number: 6143849Abstract: Multifunctional chelating groups are covalently bound to acrylate or methylate monomers. These monomers are polymerized. The resulting polymers are highly substituted with chelating groups and are useful for removing metals from fluids such as liquid hydrocarbons. An example of a polymer according to this invention has the following structure: ##STR1## wherein Q is a saturated or unsaturated aliphatic group having 1 to about 200 carbon atoms and is typically an unsubstituted unbranched alkylene, a substituted unbranched alkylene, a substituted branched alkylene, or an unsubstituted branched alkylene, and is an integer having a value of at least 1.Type: GrantFiled: November 27, 1996Date of Patent: November 7, 2000Assignee: The United States of America as represented by the Secretary of the NavyInventors: Dhananjay B. Puranik, Eddie L. Chang
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Patent number: 6077421Abstract: A composition including a solid substrate, a metal chelant, and a saturated hydrocarbon linker attached between the substrate and the chelant. The position is used in the method for removing from a liquid medium a metal having atomic number equal to or greater than 27, the method including the steps of passing the liquid medium through the composition that is in solid, particulate form and separating the medium from the composition.Type: GrantFiled: July 18, 1996Date of Patent: June 20, 2000Assignee: The United States of America as represented by the Secretary of the NavyInventors: Dhananjay Puranik, Robert E. Morris, Eddie L. Chang
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Patent number: 5098588Abstract: A new class of lubricants based on the general features of archaebacterial lipids but not limited to lipids solely extracted from archaebacteria is described. These lubricant/additive molecules have the following features: bipolarity, ether bonds and branched biphytanyl chains. They can be double chained or single chained. This new class has the potential to be highly thermally and chemically stable due to the above mentioned features.Type: GrantFiled: November 29, 1989Date of Patent: March 24, 1992Assignee: The United States of America as represented by the Secretary of the NavyInventor: Eddie L. Chang
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Patent number: 4652257Abstract: Polymerizable lipids are used to encapsulate therapeutic agents and ferronetic particles into lipid vesicles. The vesicles are polymerized, injected into the body upstream of a targeted capillary bed, allowed to flow within the bloodstream to the targeted site, and held there by an externally applied magnetic field. The magnetic field is oscillated at sufficient periodicity to destabilize or disrupt the vesicle membrane thus effecting a controlled release of the therapeutic agent.Type: GrantFiled: March 21, 1985Date of Patent: March 24, 1987Assignee: The United States of America as represented by the Secretary of the NavyInventor: Eddie L. Chang