Patents by Inventor Edgar Cook

Edgar Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties
    Patent number: 10087211
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 2, 2018
    Assignees: RESEARCH TRIANGLE INSTITUTE, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Scott P. Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20170051008
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: November 2, 2016
    Publication date: February 23, 2017
    Applicants: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Herman NAVARRO, Rafal KAMINSKI, Matthew ORR
  • Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
    Patent number: 9518080
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: December 13, 2016
    Assignees: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Scott P Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20140094619
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: August 23, 2013
    Publication date: April 3, 2014
    Applicants: US GOV BY THE SEC. OF DEPT. OF HEALTH & HUMAN SERV, RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Hernan NAVARRO, Rafal KAMINSKI, Matthew ORR
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20110092473
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: June 16, 2008
    Publication date: April 21, 2011
    Applicants: Research Triangle Institute, US GOV BY THE SEC. OF DEPT. OF HEALTH & HUMAN SERV.
    Inventors: Scott P. Runyon, Michael Rogawski, Edgar Cook, Kevin M. Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • ANTISPERMATOGENIC, SPERMICIDAL AND/OR ANTIFUNGAL COMPOSITION AND METHODS OF USING THE SAME
    Publication number: 20090238760
    Abstract: Hexahydroindenopyridine compounds are disclosed which act as contraceptive agents by disrupting spermatogenesis, acting as spermicides or sperm motility inhibitors and/or act as antifungals; antispermatogenic, sperm motility inhibitors, spermicidal or antifungal compositions containing the compounds; and methods for disrupting spermatogenesis, inhibiting sperm motility, killing motile sperm or treating fungi using the compounds and compositions. Also disclosed are radioactive compounds which may be used to study the binding of antifertility compounds to specific sites in the body and the use of such compounds for that purpose.
    Type: Application
    Filed: April 19, 2007
    Publication date: September 24, 2009
    Applicant: Research Triangle Institute
    Inventors: Clarence Edgar Cook, Kevin M Cook, Clyde Ray Tallent, Brian Frazier Thomas, Hernan Andres Navarro
  • SPERMICIDAL AND/OR ANTIFUNGAL COMPOSITION AND METHODS OF USING THE SAME
    Publication number: 20090149490
    Abstract: Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.
    Type: Application
    Filed: November 25, 2008
    Publication date: June 11, 2009
    Applicant: Research Triangle Institute
    Inventors: Clarence Edgar Cook, Carol Delta Sloan, Brian Frazier Thomas, Hernan Andres Navarro
  • Spermicidal and/or antifungal composition and methods of using the same
    Patent number: 7544696
    Abstract: Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: June 9, 2009
    Assignee: Research Triangle Institute
    Inventors: Clarence Edgar Cook, Carol Delta Sloan, Brian Frazier Thomas, Hernan Andres Navarro
  • 17?-amino and hydroxylamino-11 ?-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 7018991
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: March 28, 2006
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6864248
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: March 8, 2005
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • Spermicidal and/or antifungal composition and methods of using the same
    Publication number: 20040147539
    Abstract: Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions.
    Type: Application
    Filed: January 24, 2003
    Publication date: July 29, 2004
    Applicant: Research Triangle Institute
    Inventors: Clarence Edgar Cook, Carol Delta Sloan, Brian Frazier Thomas, Hernan Andres Navarro
  • 17&bgr;-acyl-17&agr;-propynyl-11&bgr;-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
    Patent number: 6740645
    Abstract: The invention is directed to a novel class of 17&bgr;-acyl-17&agr;-propynyl steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: May 25, 2004
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Jill M. O'Reilly
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20040097477
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: November 4, 2003
    Publication date: May 20, 2004
    Applicant: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17 Beta-amino and hydroxylamino-11 beta-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Publication number: 20040023936
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Application
    Filed: July 2, 2003
    Publication date: February 5, 2004
    Applicant: RESEARCHTRIANGLE INSTITUTE
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6670352
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: December 30, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17&bgr;-amino and hydroxylamino-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6620801
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: September 16, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20020103177
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: January 22, 2002
    Publication date: August 1, 2002
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17beta-amino and hydroxylamino-11beta-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Publication number: 20020065257
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Application
    Filed: July 2, 2001
    Publication date: May 30, 2002
    Applicant: RESEARCH TRIANGLE INSTITUTE
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6369047
    Abstract: An androgenic steroid compound of the formula: wherein: X Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: April 9, 2002
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • ANDROGENIC STEROID COMPOUNDS AND A METHOD OF MAKING AND USING THE SAME
    Publication number: 20020002156
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: June 9, 1999
    Publication date: January 3, 2002
    Inventors: C. EDGAR COOK, JOHN A. KEPLER, YUE-WEI LEE, MANSUKH C. WANI