Abstract: The novel products are water-soluble oligomers, free of N-acetyl-glucosamine units, and of which the monomer elements include a group derived from muramic acid on which is fixed a chain of the peptide type including at least two aminoacyl residues, the first being selected from among: L-alanyl, L-arginyl, L-asparagyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-methionyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tryptophanyl, L-valyl, and the second aminoacyl is D-glutamyl or D-isoglutaminyl. They are useful for their immunoregulator properties and for the preparation of pharmaceutical compositions.

Abstract: The invention relates to new compounds useful notably as regulator of immune responses and which are derivatives of muramyl peptides substituted at the end of the peptide chain by a group containing at least four carbon atoms.

Abstract: Heparin-based preparations wherein heparin is retained in or on liposomes.The lipids of said liposomes are preferably phospholipids comprising acyl chains derived from non saturated fatty acids, advantageously essential acids.These heparin-liposomes preparations have heparinic activity when administered in vivo by the oral route and a delayed-type action.

Abstract: The invention relates to novel derivatives of L-phenylalanine and particularly to tosyl-paraguanidino-L-phenylalanine methyl ester, to ter-butyloxycarbonyl derivative of para-guanidino-L-phenylalanine and to para-guanidino-L-phenylalanine.The tosyl-paraguanidino-L-phenylalanine methyl ester is an efficient trypsine substrate.

Abstract: Novel salts of papaverine are constituted by the thienyl-carboxylates of papaverine notably papaverine thienyl-2-carboxylate. A papaverine thienyl-carboxylate is prepared by reacting papaverine base with the corresponding thiophene carboxylic acid. The medicaments comprise, as active principle, a papaverine thienyl-carboxylate associated with a solid excipient making it suitable for administration by the oral route, or with an excipient making it suitable for administration by the rectal route. The medicament, is useful for the treatment of hyperspasmodicity of the smooth muscles, and for the treatment of vascular disorders, notably due to senescence, more particularly those bringing into action cortical reactivity.