Abstract: Provided herein, in some embodiments, are methods for classifying the tandem duplicator phenotype of a tumor into one of at least six TDP subtypes based on the length distribution of tandem duplications (TDs) in the genome of the tumor sample.

Abstract: Provided herein, in some embodiments, are novel methods for predicting response to a platinum-based chemotherapeutic agent in triple negative breast cancer and ovarian carcinoma.

Abstract: Provided herein, in some embodiments, are methods for classifying the tandem duplicator phenotype of a tumor.

Abstract: The invention described herein provide a method to quantitatively determine the extent of tandem duplications (TDs) in certain cancer, and the use of the novel scoring metric to determine whether the cancers exhibiting tandem duplicator phenotype (TDP) and their increased susceptibility to platinum-based chemotherapeutic agents.

Abstract: A correlation between expression of JMJD6 polypeptide and breast cancer metastasis exists accordingly the present invention relates a diagnostic, prognostic and therapeutic biomarker to distinguish between early and advanced/metastatic cancer particularly breast cancer, including compounds and methods to treat the same.

Abstract: There is provided at least one isolated fused gene comprising at least one first gene and/or fragment thereof fused to at least one second gene and/or fragment thereof, wherein at least the first and/or the second gene, independently, is selected from the group consisting of: RCC2, CENPF, ARFGEF2, SULF2, MTAP, ATXN7, BCAS3, RPS6KB1, TMEM49, EAP30, a gene having the nucleotide sequence SEQ ID NO:1, and a gene having the nucleic acid SEQ ID NO:2, or a fragment thereof. There is also provided a diagnostic method and/or a kit for detecting the susceptibility, prognosis, and/or to tumour in a subject.

Abstract: The present invention provides methods, compositions and kits for the prognosis, characterization and treatment of cancers. The methods, compositions and kits of the invention comprise a set of markers whose expression is correlated with estrogen receptor beta function. Therefore, the methods, compositions and kits of the invention find particular use in endocrine-related cancers such as breast cancers.

Abstract: A nuclear tyrosine kinase called Rak has been identified. This tyrosine kinase is expressed primarily in epithelial cells, and has been found to be a growth inhibiting kinase. Domains of the Rak protein, and corresponding peptides, have been found to inhibit CDC2 function and therefore block the cell cycle and inhibit cell growth. A domain of the Rak protein which binds to the retinoblastoma gene product has also been identified, and is in a domain distinct from the CDC2 binding region. Peptides which bind to CDC2, and peptides which bind to the retinoblastoma gene product, are described.

Abstract: Oligonucleoside compounds useful in inhibiting expression of focal adhesion kinase protein in animals, and related methods and formulations for reducing cancer cell growth, invasion and metastasis. The compounds are selected to be complementary to a target region of a focal adhesion kinase nucleic acid sequence, preferably human FAK mRNA.

Abstract: Isolated DNA sequences encoding a mammalian axl receptor which exhibits axl oncogene activity are disclosed. Also disclosed are vectors containing such DNA sequences, host cells containing such DNA sequences, axl receptor proteins, and soluble axl receptors, chimeric proteins including the extracellular domain of the axl receptor and DNA sequences encoding such chimeric proteins, and antibodies which specifically bind the axl receptor.