Abstract: In general, a method for removal of pyrogens from plasma or blood according to the present invention comprises: (1) passing the biological fluid through a resin comprising two components: (a) a first component comprising a polymeric support with a multiplicity of ligands comprising a C10-C24 alkylamino group, the ligands specifically binding endotoxin; and (b) a second component comprising a halogenated quinolone moiety immobilized on an amino-group-containing solid support by the formation of an amide linkage, the first component and the second component being present in the resin at a ratio of from about 20:80 (v/v) to about 80:20 (v/v); and (2) collecting the biological fluid from which pyrogens have been removed. Preferably, the alkylamino group is a stearylamino group, and the ligands are cross-linked and quaternized by reaction with a dibromoalkanol. Preferably, the polymeric support of the first component is agarose in particulate form.

Abstract: In general, a method for removal of pyrogens from plasma or blood according to the present invention comprises: (1) passing the biological fluid through a resin comprising two components: (a) a first component comprising a polymeric support with a multiplicity of ligands comprising a C10-C24 alkylamino group, the ligands specifically binding endotoxin; and (b) a second component comprising a halogenated quinolone moiety immobilized on an amino-group-containing solid support by the formation of an amide linkage, the first component and the second component being present in the resin at a ratio of from about 20:80 (v/v) to about 80:20 (v/v); and (2) collecting the biological fluid from which pyrogens have been removed. Preferably, the alkylamino group is a stearylamino group, and the ligands are cross-linked and quaternized by reaction with a dibromoalkanol. Preferably, the polymeric support of the first component is agarose in particulate form.

Abstract: The present invention provides a decorative cosmetic composition that is visually distinct comprising a translucent or transparent particle and a cosmetic base. In addition, the present invention provides a decorative cosmetic composition that has both a functional effect, such as for cleansing or massage, and a distinct visual effect.

Abstract: A new method is described to produce large volumes of low cost water for injection directly from potable water in order to meet the needs of hemodialysis and other biological applications for ultrapure water. The source water is processed by a combination of membrane and chromatographic methods including reverse osmosis, ion exchange deionization, endotoxin-specific adsorption steps and polishing filtration to reduce contaminant levels below those specified by the US Pharmacopoiea. Endotoxin removal from dialysate was demonstrated. The endotoxin removing adsorbent also adsorbs LAL-negative pyrogens from the test samples.