Patents by Inventor Edmund C. Lattime

Edmund C. Lattime has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEUTRALIZING FACTORS AS VACCINE ADJUVANTS
    Publication number: 20130045234
    Abstract: The present invention is a vaccine adjuvant composed of a vaccinia virus vector that encodes a polypeptides capable of neutralizing immune suppressive factors thereby enhancing or stimulating an immune response to a vaccine.
    Type: Application
    Filed: July 16, 2012
    Publication date: February 21, 2013
    Inventors: Edmund C. Lattime, Claude Monken
  • Immunotherapy for Unresectable Pancreatic Cancer
    Publication number: 20110104101
    Abstract: The present invention provides a novel cancer immunotherapy comprising a vaccination schedule of both intratumoral and systemic injections followed by peripheral boost injection. The immunotherapy can then be followed by other standard treatment as is known in the art for locoregional or metastatic pancreatic cancer. The present invention further provides a kit for administering the cancer immunotherapy described herein. The present invention further provides a method of decreasing the dose of cancer immunotherapy vaccines.
    Type: Application
    Filed: March 9, 2009
    Publication date: May 5, 2011
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventor: Edmund C. Lattime
  • Neutralization of immune suppressive factors for the immunotherapy of cancer
    Publication number: 20030206886
    Abstract: The invention provides vectors comprising nucleic acid molecules that encode polypeptides capable of binding immune suppressive factors for the immunotherapy of cancer.
    Type: Application
    Filed: May 3, 2002
    Publication date: November 6, 2003
    Applicant: University of Medicine & Dentistry of New Jersey
    Inventors: Edmund C. Lattime, Claude E. Monken
  • Method of inducing an immune response using vaccinia virus recombinants
    Publication number: 20030086906
    Abstract: A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
    Type: Application
    Filed: November 4, 2002
    Publication date: May 8, 2003
    Inventors: Michael J. Mastrangelo, Edmund C. Lattime, David Berd, Laurence C. Eisenlohr
  • Method of inducing an immune response using vaccinia virus recombinants
    Patent number: 6475999
    Abstract: A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
    Type: Grant
    Filed: June 19, 2000
    Date of Patent: November 5, 2002
    Assignee: Thomas Jefferson University
    Inventors: Michael J. Mastrangelo, Edmund C. Lattime, David Berd, Laurence C. Eisenlohr
  • Method of treating bladder cancer with wild type vaccinia virus
    Patent number: 6177076
    Abstract: Methods of treating bladder cancer in a patient by administration of wildtype vaccinia virus are provided.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: January 23, 2001
    Assignee: Thomas Jefferson University
    Inventors: Edmund C. Lattime, Michael J. Mastrangelo
  • Method of inducing an immune response using vaccinia virus recombinants encoding GM-CSF
    Patent number: 6093700
    Abstract: A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: July 25, 2000
    Assignee: Thomas Jefferson University
    Inventors: Michael J. Mastrangelo, Edmund C. Lattime, David Berd, Laurence C. Eisenlohr