Patents by Inventor Edoardo Mannucci

Edoardo Mannucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AAV mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity
    Patent number: 11207361
    Abstract: The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: December 28, 2021
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Giovanni DiPasquale, Edoardo Mannucci
  • AAV Mediated Exendin-4 Gene Transfer to Salivary Glands to Protect Subjects from Diabetes or Obesity
    Publication number: 20190298785
    Abstract: The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
    Type: Application
    Filed: April 26, 2019
    Publication date: October 3, 2019
    Inventors: John A. Chiorini, Giovanni DiPasquale, Edoardo Mannucci
  • AAV mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity
    Patent number: 10300095
    Abstract: The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: May 28, 2019
    Assignee: The United States of America, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: John A. Chiorini, Giovanni DiPasquale, Edoardo Mannucci
  • AAV Mediated Exendin-4 Gene Transfer to Salivary Glands to Protect Subjects from Diabetes or Obesity
    Publication number: 20170143779
    Abstract: The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
    Type: Application
    Filed: December 5, 2016
    Publication date: May 25, 2017
    Inventors: John A. Chiorini, Giovanni DiPasquale, Edoardo Mannucci
  • AAV mediated exendin-4 gene transfer to salivary glands to protect subjects from diabetes or obesity
    Patent number: 9511103
    Abstract: The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: December 6, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Giovanni Di Pasquale, Edoardo Mannucci
  • AAV MEDIATED EXENDIN-4 GENE TRANSFER TO SALIVARY GLANDS TO PROTECT SUBJECTS FROM DIABETES OR OBESITY
    Publication number: 20140199272
    Abstract: The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
    Type: Application
    Filed: April 19, 2012
    Publication date: July 17, 2014
    Applicants: Health and Human Services
    Inventors: John A. Chiorini, Giovanni Di Pasquale, Edoardo Mannucci