Patents by Inventor Eduard Gerhard Talman

Eduard Gerhard Talman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Labeled transition metal complexes
    Patent number: 9188590
    Abstract: The invention relates to a labeled transition metal complex comprising a transition metal atom, a reactive moiety for allowing a chemical or biological entity to become attached to the transition metal atom, an inert tridentate moiety as a stabilizing bridge, and a marker. The invention also relates to a labeled chemical or biological entity comprising a chemical or biological entity which is attached to said labeled transition metal complex, to the use of said complex for creating a defined shift in the molecular mass of said entity in order to facilitate mass spectrometric analysis of said entity, to methods for rendering chemical or biological entities distinguishable by mass spectrometry as well as to methods for mass spectrometric analysis of the chemical or biological entities.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: November 17, 2015
    Assignee: LEICA BIOSYSTEMS NEWCASTLE LTD.
    Inventors: Marie Lacombe, Franciscus Johannes Opdam, Eduard Gerhard Talman, Jacky Theo Maria Veuskens
  • Method of conjugating therapeutic compounds to cell targeting devices via metal complexes
    Publication number: 20110104103
    Abstract: The present invention relates to a cell-targeting complex comprising a targeting moiety and a deliverable compound, wherein said targeting moiety and said deliverable compound are joined by means of a (transition) metal ion complex having at least a first reactive moiety for forming a coordination bond with a reactive site of said targeting moiety and having at least a second reactive moiety for forming a coordination bond with a reactive site of said deliverable compound, and wherein said deliverable compound is a therapeutic compound.
    Type: Application
    Filed: July 20, 2006
    Publication date: May 5, 2011
    Applicant: KREATECH BIOTECHNOLOGY B.V.
    Inventors: Robert Jochem Heetebrij, Robbert Jan Kok, Eduard Gerhard Talman, Klaas Poelstra, Grietje Molema
  • DIFFERENTIAL LABELLING METHOD
    Publication number: 20100267056
    Abstract: The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit to employ a method according to the invention.
    Type: Application
    Filed: April 26, 2010
    Publication date: October 21, 2010
    Applicant: KREATECH BIOTECHNOLOGY B.V.
    Inventors: Eduard Gerhard Talman, Robertus Petrus Maria van Gijlswijk, Robert Jochem Heetebrij, Jacky Theo Maria Veuskens
  • LABELED TRANSITION METAL COMPLEXES
    Publication number: 20100155590
    Abstract: The invention relates to a labeled transition metal complex comprising a transition metal atom, a reactive moiety for allowing a chemical or biological entity to become attached to the transition metal atom, an inert tridentate moiety as a stabilizing bridge, and a marker. The invention also relates to a labeled chemical or biological entity comprising a chemical or biological entity which is attached to said labeled transition metal complex, to the use of said complex for creating a defined shift in the molecular mass of said entity in order to facilitate mass spectrometric analysis of said entity, to methods for rendering chemical or biological entities distinguishable by mass spectrometry as well as to methods for mass spectrometric analysis of the chemical or biological entities.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 24, 2010
    Applicant: Kreatch Biotechnology B.V.
    Inventors: Marie Lacombe, Franciscus Johannes Opdam, Eduard Gerhard Talman, Jacky Theo Maria Veuskens
  • Differential labelling method
    Patent number: 7704755
    Abstract: The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit to employ a method according to the invention.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: April 27, 2010
    Assignee: Kreatech Biotechnology B.V.
    Inventors: Eduard Gerhard Talman, Robertus Petrus Maria van Gijlswijk, Robert Jochem Heetebrij, Jacky Theo Maria Veuskens
  • Differential labelling method
    Publication number: 20030060647
    Abstract: The invention relates to a method for differentially labelling one or more entities, together comprising distinct reactive sites. The invention further relates to an entity that has been labelled by a method according to the invention and to a diagnostic kit comprising a labelled entity and to a diagnostic kit to employ a method according to the invention.
    Type: Application
    Filed: May 28, 2002
    Publication date: March 27, 2003
    Inventors: Eduard Gerhard Talman, Robertus Petrus Maria van Gijlswijk, Robert Jochem Heetebrij, Jacky Theo Maria Veuskens