Patents by Inventor Eduardo L. Setti

Eduardo L. Setti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Haloalkyl containing compounds as cysteine protease inhibitors
    Patent number: 8013186
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: September 6, 2011
    Assignee: Virobay, Inc.
    Inventor: Eduardo L. Setti
  • Haloalkyl Containing Compounds as Cysteine Protease Inhibitors
    Publication number: 20090023781
    Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.
    Type: Application
    Filed: December 1, 2005
    Publication date: January 22, 2009
    Applicant: Virobay, Inc.
    Inventor: Eduardo L. Setti
  • Cyanoalkylamino derivatives as protease inhibitors
    Patent number: 7371747
    Abstract: The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by unregulated cysteine protease activity, in particular cathepsin K utilizing these compounds and methods of preparing these compounds are also disclosed.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: May 13, 2008
    Assignee: Merck Frosst Canada & Co.
    Inventors: Cameron Black, Sheldon N. Crane, Dana Davis, Eduardo L. Setti
  • Hydroxamates as therapeutic agents
    Patent number: 7368476
    Abstract: The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: May 6, 2008
    Assignee: Pharmacyclics, Inc.
    Inventor: Eduardo L. Setti
  • Cathepsin cysteine protease inhibitors
    Patent number: 7012075
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 14, 2006
    Assignees: Merck & Co., Inc., Axys Pharmaceuticals, Inc.
    Inventors: Petpihoon Prasit, Christopher Ian Bayly, Joel Stephane Robichaud, W. Cameron Black, Eduardo L. Setti, Robert M. Rydzewski, James T. Palmer
  • Cathepsin cysteine protease inhibitors
    Publication number: 20040198982
    Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
    Type: Application
    Filed: August 28, 2003
    Publication date: October 7, 2004
    Inventors: Petpihoon Prasit, Christopher Ian Bayly, Joel Stephane Robichaud, W. Cameron Black, Eduardo L. Setti, Robert M. Rydzewski, James T. Palmer
  • Compounds and compositions as protease inhibitors
    Patent number: 6593327
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: July 15, 2003
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Novel compounds and compositions as protease inhibitors
    Publication number: 20030119788
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: September 9, 2002
    Publication date: June 26, 2003
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Compounds and compositions as protease inhibitors
    Patent number: 6476026
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: November 5, 2002
    Assignee: Axys Pharmaceuticals, Inc.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Arylacetamido-ketobenzoxazole as cysteine protease inhibitors
    Publication number: 20020156063
    Abstract: The present invention thus provides compounds of Formula I: 1
    Type: Application
    Filed: April 8, 2002
    Publication date: October 24, 2002
    Inventors: Eduardo L. Setti, Shankar Venkatraman
  • Novel compounds and compositions as protease inhibitors
    Publication number: 20020086996
    Abstract: The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
    Type: Application
    Filed: December 14, 2001
    Publication date: July 4, 2002
    Applicant: AXYS PHARMACEUTICALS, INC.
    Inventors: Clifford M. Bryant, James T. Palmer, Robert M. Rydzewski, Eduardo L. Setti, Zong-Qiang Tian, Shankar Venkatraman, Dan-Xiong Wang
  • Azetidinone derivatives as .beta.-lactamase inhibitors
    Patent number: 5994340
    Abstract: New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial .beta.-lactamases. These compounds can be used in combination with .beta.-lactam antibiotics to increase the effectiveness of the .beta.-lactam antibiotics in fighting infection caused by .beta.-lactamase producing bacteria.
    Type: Grant
    Filed: August 29, 1997
    Date of Patent: November 30, 1999
    Assignee: SynPhar Laboratories, Inc.
    Inventors: Samarendra N. Maiti, Oludotun A. Phillips, Eduardo L. Setti, Andhe V. Narender Reddy, Ronald G. Micetich, Fusahiro Higashitani, Chieko Kunugita, Koichi Nishida, Tatsuya Uji
  • 2-oxo-1-azetidine sulfonic acid derivatives as potent .beta.-lactamase inhibitors
    Patent number: 5888998
    Abstract: A compound of formula (I) ##STR1## wherein R.sub.1 is selected from the group consisting of 2-thienyl, 2-furyl, 2-pyrrolyl, 1-methyl-2-pyrrolyl, 2-amino-1-thiazolyl and 5-isothiazolyl;R.sub.2 is selected from the group consisting of: ##STR2## and M is hydrogen or a pharmaceutically acceptable cation; wherein the oxyimino fragment (.dbd.N--OR.sub.2) in formula (I) is in the `anti` orientation.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: March 30, 1999
    Assignees: Synphar Laboratories, Inc., Taiho Pharmaceutical Co., Ltd.
    Inventors: Samarendra N. Maiti, Eduardo L. Setti, Oludotun A. Phillips, Andhe V. Narender Reddy, Ronald G. Micetich, Rajeshwar Singh, Fusahiro Higashitani, Chieko Kunugita, Koichi Nishida, Tatsuya Uji