Abstract: An automated method is provided for enabling and implementing a beacon-based service location application in a user device having a beacon monitoring application. A service location facilitation server establishes service need criteria for a user of the user device and estimates a service need state for the user. The service need state includes information indicative of a relative need for a desired service. The service location facilitation server then determines whether the service need state meets the service need criteria, and, if so, transmits an instruction to the user device to transition the beacon monitoring application from an inactive state to an active monitoring state.

Abstract: This invention relates to novel compounds according to Formula (I) which are antagonists of MrgX2, to pharmaceutical compositions containing them, and to their use in therapy for the treatment of MrgX2-mediated diseases and disorders.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: A refrigerator mirror weight monitor apparatus for weight loss assistance includes a frame and a plurality of mounting strips to selectively engage the frame with a refrigerator or pantry door. A mirror is coupled to the frame and a housing extends from the mirror to a frame top side. A display is coupled to the housing. A CPU is coupled within the housing and is in operational communication with the display. A memory, a receiver, and a battery are coupled within the housing and are in operational communication with the CPU. A sensor has a sensor housing, a weight monitor coupled within the sensor housing, and a transmitter coupled within the sensor housing. The transmitter is in operational communication with the weight monitor and in wireless communication with the receiver.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining a content theme that includes a set of visual components and accessing control panels of a design system. The control panels are configured to provide control functions for adjusting attributes of the components. The control panels receive a selection of a first component that is linked to at least a second component in the set of visual components. An attribute of the first component is adjusted in response to detecting user interaction with a control panel. The user interaction causes adjustment of an attribute of a second component based on the adjusting of the attribute of the first component because of the second component being linked to the first component. Graphical content is created for output at a display based on the adjusted attributes of the first and second components.

Abstract: A refrigerator mirror weight monitor apparatus for weight loss assistance includes a frame and a plurality of mounting strips to selectively engage the frame with a refrigerator or pantry door. A mirror is coupled to the frame and a housing extends from the mirror to a frame top side. A display is coupled to the housing. A CPU is coupled within the housing and is in operational communication with the display. A memory, a receiver, and a battery are coupled within the housing and are in operational communication with the CPU. A sensor has a sensor housing, a weight monitor coupled within the sensor housing, and a transmitter coupled within the sensor housing. The transmitter is in operational communication with the weight monitor and in wireless communication with the receiver.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for obtaining a content theme that includes a set of visual components and accessing control panels of a design system. The control panels are configured to provide control functions for adjusting attributes of the components. The control panels receive a selection of a first component that is linked to at least a second component in the set of visual components. An attribute of the first component is adjusted in response to detecting user interaction with a control panel. The user interaction causes adjustment of an attribute of a second component based on the adjusting of the attribute of the first component because of the second component being linked to the first component. Graphical content is created for output at a display based on the adjusted attributes of the first and second components.

Abstract: The present invention relates to the characterization and production of alemtuzumab.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.

Abstract: Sulfated glycoproteins, and methods of making and using such sulfated glycoproteins, are described.

Abstract: The present invention relates to the characterization and production of biologics.

Abstract: The present invention relates to the characterization and production of adalimumab.

Abstract: Methods of making and evaluating biologic therapeutic products are disclosed.

Abstract: Methods and compositions related to high mannose glycans are described.

Abstract: A gonioscopic attachment can attach to a gonioscope and can include atraumatic retention elements that are configured to engage an eye to retain the gonioscope relative to the eye. The gonioscopic attachment can be configured to position the gonioscope so that at least a portion of the concave distal surface of the gonioscopic optical element is spaced apart from the eye, and/or so that the curvature of the distal surface is angularly offset from the curvature of the eye. The gonioscope can include a fixation point configured to be visible to the subject when the gonioscope is positioned on the eye. In some embodiments, the retention elements can be incorporated directly into the gonioscope. A coupling mechanism can couple the gonioscope to a lid speculum. The gonioscope can include a light pipe, which can be configured to directly light into the eye.