Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: Apparatus, systems and methods for receiving signals from a human subject's head includes a headset having a plurality of electroencephalographic “(EEG”) electrodes associated therewith for facilitating receiving EEG signals from the subject's head and at least one ear clip configured to be releasably secured to the subject's ear(s).

Abstract: Apparatus and methods for use in connection with receiving signals from a human subject's head through the scalp thereof includes a removable headset having a plurality of electrode stations and intermediate portions. Each electrode station includes an electrode aperture extending therethrough and a biasing flap coupled to the headset and at least partially aligned over the associated electrode aperture. A plurality of removable electrodes is releasably engageable with the headset and configured to be releasably suspended within the electrode apertures and biased between the headset and the subject's head by the associated biasing flaps.

Abstract: Apparatus for use in connection with receiving signals from a human subject's head through the scalp thereof includes a removable headset having a plurality of electrode stations and intermediate portions. Each electrode station includes an electrode aperture extending therethrough and a biasing flap coupled to the outer side of the headset and at least partially aligned over the associated electrode aperture. A plurality of removable electrodes is releasably engageable with the headset and configured to be releasably suspended within the electrode apertures and biased between the headset and the subject's head by the associated biasing flaps.