Patents by Inventor Edward J. Filardo

Edward J. Filardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GPER PROTEOLYTIC TARGETING CHIMERAS
    Publication number: 20230312639
    Abstract: A molecule comprising a G-protein coupled estrogen receptor (GPER) ligand coupled to a linker coupled to an E3 ubiquitin ligase ligand and methods of using the molecule are provided. In one embodiment, the GPER ligand is estradiol and the E3 ubiquitin ligase ligand is (S,R,S)- AHPC.
    Type: Application
    Filed: April 23, 2021
    Publication date: October 5, 2023
    Inventors: Aliasger K. Salem, Edward J. Filardo, Anh S. Lu, Milad Rouhimoghadam
  • GPR30 estrogen receptor in breast cancers
    Patent number: 7803561
    Abstract: The invention provides methods of identifying metastatic disease as well as ligands such as antibodies that bind to GPR30. These antibodies are useful in the detection or treatment of endocrine tumors.
    Type: Grant
    Filed: February 6, 2007
    Date of Patent: September 28, 2010
    Assignee: Rhode Island Hospital
    Inventors: Edward J. Filardo, Edmond Sabo
  • GPR30 ESTROGEN RECEPTOR IN BREAST AND OVARIAN CANCERS
    Publication number: 20100190199
    Abstract: A method of prognosis for ovarian or breast cancer patients is carried out by detecting GPR30 in a sample of tissue. An elevation in the level of GPR30 compared to a normal control level indicates presentation of late stage disease and indicates responsiveness of the tumor to hormonal therapy.
    Type: Application
    Filed: September 28, 2009
    Publication date: July 29, 2010
    Applicant: Rhode Island Hospital
    Inventors: Edward J. Filardo, Edmond Sabo
  • GPR30 estrogen receptor in breast cancers
    Publication number: 20080131915
    Abstract: The invention provides methods of identifying metastatic disease as well as ligands such as antibodies that bind to GPR30. These antibodies are useful in the detection or treatment of endocrine tumors.
    Type: Application
    Filed: February 6, 2007
    Publication date: June 5, 2008
    Inventors: Edward J. Filardo, Edmond Sabo