Patents by Inventor Edward J. Gavin
Edward J. Gavin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7860685Abstract: Methods for processing spectra are disclosed. The method includes obtaining a plurality of spectra, each spectrum in the plurality of spectra comprising a signal including a signal strength as a function of time-of-flight, mass-to-charge ratio, or a value derived from time-of-flight or mass-to-charge ratio. Then, a signal cluster is formed by clustering signals from the plurality of spectra with time-of-flights, mass-to-charge ratios, or values derived from time-of-flights or mass-to-charge ratios that are within a window that is defined using an expected signal width value.Type: GrantFiled: January 20, 2005Date of Patent: December 28, 2010Assignee: Bio-Rad Laboratories, Inc.Inventors: Patrick Ho, Edward J. Gavin
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Patent number: 7027933Abstract: A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.Type: GrantFiled: September 23, 2003Date of Patent: April 11, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: Chris D. Paulse, Edward J. Gavin, Leonid Braginsky, William E. Rich, Eric T. Fung
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Patent number: 6909981Abstract: One embodiment of the invention is directed to a method of processing a plurality of spectra. The method includes receiving values associated with a plurality of sample spots on one or more sample chips, wherein the values were entered using graphic elements representing the sample spots, the graphic elements being displayed on a graphical user interface. Data representing a plurality of signals are received. Each signal in the plurality of signals is annotated with a set of values associated with the sample spot from which the signal is generated.Type: GrantFiled: January 8, 2004Date of Patent: June 21, 2005Assignee: Ciphergen Biosystems, Inc.Inventors: Edward J. Gavin, Cynthia Enderwick, Patrick Ho, Niels Kirk Thomsen
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Publication number: 20040159783Abstract: One embodiment of the invention is directed to a method of processing a plurality of spectra. The method includes receiving values associated with a plurality of sample spots on one or more sample chips, wherein the values were entered using graphic elements representing the sample spots, the graphic elements being displayed on a graphical user interface. Data representing a plurality of signals are received. Each signal in the plurality of signals is annotated with a set of values associated with the sample spot from which the signal is generated.Type: ApplicationFiled: January 8, 2004Publication date: August 19, 2004Applicant: Ciphergen Biosystems, Inc.Inventors: Edward J. Gavin, Cynthia Enderwick, Patrick Ho, Niels Kirk Thomsen
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Publication number: 20040059530Abstract: A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.Type: ApplicationFiled: September 23, 2003Publication date: March 25, 2004Applicant: Ciphergen Biosystems, Inc.Inventors: Chris D. Paulse, Edward J. Gavin, Leonid Braginsky, William E. Rich, Eric T. Fung
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Patent number: 6675104Abstract: A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.Type: GrantFiled: November 15, 2001Date of Patent: January 6, 2004Assignee: Ciphergen Biosystems, Inc.Inventors: Chris D. Paulse, Edward J. Gavin, Leonid Braginsky, William E. Rich, Eric T. Fung
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Patent number: 6586728Abstract: A method and system of detecting mass to charge ratio of ions. The method includes producing charged ions in a vacuum, accelerating the charged ions in an electric field into a free flight tube and detecting the charged ions at a detector associated with the free flight tube. A control system selects a bandwidth for filtering a signal produced by the detector and the signal produced by the detector is then filtered with a variable width digital filter based upon the selected bandwidth. The bandwidth for filtering the signal may be selected from a look-up table within the control system based upon the mass to charge ratio of an ion of interest. Alternatively, a peak bandwidth within the signal produced by the detector may be determined and the signal produced by the detector may then be filtered with the variable width digital filter based upon the determined peak bandwidth.Type: GrantFiled: May 11, 2000Date of Patent: July 1, 2003Assignee: Ciphergen Biosystems, Inc.Inventors: Edward J. Gavin, Leonid Braginsky
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Patent number: 6580071Abstract: A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.Type: GrantFiled: July 11, 2002Date of Patent: June 17, 2003Assignee: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Edward J. Gavin, Michael G. Youngquist
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Publication number: 20030062473Abstract: A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.Type: ApplicationFiled: July 11, 2002Publication date: April 3, 2003Applicant: Ciphergen Biosystems, Inc.Inventors: Scot R. Weinberger, Edward J. Gavin, Michael G. Youngquist
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Publication number: 20020193950Abstract: A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.Type: ApplicationFiled: February 25, 2002Publication date: December 19, 2002Inventors: Edward J. Gavin, Leonid Braginsky, William E. Rich, Eric T. Fung, George L. Wright
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Publication number: 20020138208Abstract: A method that analyzes mass spectra using a digital computer is disclosed. The method includes entering into a digital computer a data set obtained from mass spectra from a plurality of samples. Each sample is, or is to be assigned to a class within a class set having two or more classes and each class is characterized by a different biological status. A classification model is then formed. The classification model discriminates between the classes in the class set.Type: ApplicationFiled: November 15, 2001Publication date: September 26, 2002Applicant: Ciphergen Biosystems, Inc.Inventors: Chris D. Paulse, Edward J. Gavin, Leonid Braginsky, William E. Rich, Eric T. Fung