Patents by Inventor Edward J. Ginns

Edward J. Ginns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloned DNA for synthesizing unique glucocerebrosidase
    Patent number: 5879680
    Abstract: The invention is directed to a pharmaceutical composition comprising a therapeutic amount of a glycosylated recombinantly-produced human glucocerebrosidase protein in a pharmaceutically acceptable carrier. The invention is further directed to a method of treating Gaucher's disease comprising administering to a subject afflicted with Gaucher's disease a therapeutic amount of a pharmaceutical composition comprising a therapeutic amount of a glycosylated recombinantly-produced human glucocerebrosidase protein in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: March 9, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Edward J. Ginns, Brian Martin, Kara A. Maysak, William K. Eliason, Mary E. LaMarca
  • Glycolipid enzyme-polymer conjugates
    Patent number: 5705153
    Abstract: Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: January 6, 1998
    Assignee: The United States of America, as represented by The Department of Health and Human Services
    Inventors: Robert G. L. Shorr, Carl W. Gilbert, Brian M. Martin, Myung-Ok Cho, Edward J. Ginns
  • Glycolipid enzyme-polymer conjugates
    Patent number: 5620884
    Abstract: Conjugates containing glucocerebrosidase and non-antigenic polymers such as polyethylene glycol are disclosed. The conjugates circulate for extended times and have prolonged activity in vivo when compared to unmodified enzymes. The conjugates are useful in the treatment of Gaucher's Disease and have improved enzyme activity at the pH ranges associated with lysosomal, arterial and capillary regions.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: April 15, 1997
    Assignee: Enzon, Inc.
    Inventors: Robert G. L. Shorr, Myung-Ok Cho, Carl W. Gilbert, Edward J. Ginns, Brian M. Martin