Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

Abstract: An occlusive device includes a covering component configured to modulate passage of blood or thrombus therethrough, and an occlusion frame that includes a plurality of elongate occlusion frame members. The elongate occlusion frame members are arranged to form a generally disc-shaped member. The occlusion frame is at least partially covered by the covering component. The device further includes an anchor frame that includes a plurality of elongate anchor frame members. The device further includes a first hub component from which the elongate frame members extend, and a second hub component from which the elongate frame members extend.

Abstract: A timing control arrangement that dynamically controls the distribution of timing information in a distributed digital communication system having standard nodes and prioritized master nodes. Reference timing signals to control the system are distributed from the highest priority master node currently operational. Should a higher priority master node than the current master node become operational, the higher priority master node automatically takes control of the timing for the system. Each node is connected by links to at least one other node, and each node receives timing signals and a timing priority number (TPN) from all of the connected node. The TPN defines the number of links over which the timing signals travel to the receiving node from the current master node. Each standard node selects timing signals and TPN from the link having the lowest TPN and transmits the selected TPN (after incrementing the selected TPN by one) and timing signals on all connected outgoing links.