Patents by Inventor Edward Lakatos
Edward Lakatos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8865473Abstract: A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. A detecting apparatus may be configured so that light from luminescent samples pass through a collimator, a first lens, a filter, and a camera lens, whereupon an image is created by the optics on the charge-coupled device (CCD) camera. The detecting apparatus may further include central processing control of all operations, multiple wavelength filter wheel, and/or a robot for handling of samples and reagents.Type: GrantFiled: August 13, 2012Date of Patent: October 21, 2014Assignee: Applied Biosystems, LLCInventors: Michael Gambini, Jeff Levi, John Voyta, Bruce E. DeSimas, II, Edward Lakatos, Israel Metal, George Sabak, Yongdong Wang, Susan A. Atwood-Stone
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Patent number: 8532931Abstract: A method for calculating a sample size for a clinical trial of a first treatment can be provided. The method can include reading a survival curve from a clinical trial for a second treatment, wherein the clinical trial may be selected by a user interacting with a user interface. The method can further include selecting a plurality of points on the survival curve and storing coordinates for each of the plurality of points, wherein the plurality of points are selected so as to capture substantial features of the survival curve. Then, a hazard curve is generated based on the coordinates that were stored, wherein the hazard curve may be a step function. The method can further include calculating a sample size for the clinical trial of the first treatment using a Markov model based on the hazard curve.Type: GrantFiled: September 7, 2008Date of Patent: September 10, 2013Inventor: Edward Lakatos
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Publication number: 20120309103Abstract: A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents.Type: ApplicationFiled: August 13, 2012Publication date: December 6, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Michael Gambini, John C. Voyta, John Atwood, Susan A. Atwood-Stone, Bruce E. DeSimas, II, Edward Lakatos, Jeff Levi, Israel Metal, George Sabak, Yongdong Wang
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Patent number: 8278114Abstract: A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. A detecting apparatus may be configured so that light from luminescent samples pass through a collimator, a a first lens, a filter, and a camera lens, whereupon an image is created by the optics on the charge-coupled device (CCD) camera. The detecting apparatus may further include central processing control of all operations, multiple wavelength filter wheel, and/or a robot for handling of samples and reagents.Type: GrantFiled: March 2, 2010Date of Patent: October 2, 2012Assignee: Applied Biosystems, LLCInventors: Michael Gambini, Jeff Levi, John Voyta, John Atwood, Susan Atwood-Stone, legal representative, Bruce De Simas, Edward Lakatos, Israel Metal, George Sabak, Yongdong Wang
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Publication number: 20100248387Abstract: A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents.Type: ApplicationFiled: March 2, 2010Publication date: September 30, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Michael R. Gambini, John C. Voyta, John Atwood, Susan A. Atwood-Stone, Bruce E. DeSimas, II, Edward Lakatos, Jeff Levi, Israel Metal, George Sabak, Yongdong Wang
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Publication number: 20100063741Abstract: A method for calculating a sample size for a clinical trial of a first treatment can be provided. The method can include reading a survival curve from a clinical trial for a second treatment, wherein the clinical trial may be selected by a user interacting with a user interface. The method can further include selecting a plurality of points on the survival curve and storing coordinates for each of the plurality of points, wherein the plurality of points are selected so as to capture substantial features of the survival curve. Then, a hazard curve is generated based on the coordinates that were stored, wherein the hazard curve may be a step function. The method can further include calculating a sample size for the clinical trial of the first treatment using a Markov model based on the hazard curve.Type: ApplicationFiled: September 7, 2008Publication date: March 11, 2010Inventor: Edward Lakatos
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Patent number: 7670848Abstract: In a luminescence detecting apparatus and method for analyzing luminescent samples, luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, an infrared filter, and a camera lens, whereupon a focused image is created by the optics on the camera. The use of an infrared filter suppresses stray IR radiation resulting from plate phosphorescence (which can result in abnormally high backgrounds and/or alteration of the image received by the camera).Type: GrantFiled: October 18, 2005Date of Patent: March 2, 2010Assignee: Applied Biosystems, LLCInventors: Michael R. Gambini, John C. Voyta, John Atwood, Susan A. Atwood-Stone, legal representative, Bruce E. DeSimas, II, Edward Lakatos, Jeff Levi, Israel Metal, George Sabak, Yongdong Wang
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Publication number: 20070238161Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.Type: ApplicationFiled: May 17, 2007Publication date: October 11, 2007Applicant: Applera CorporationInventors: Anthony Cerrone, Edward Lakatos, Michael Gambini, Eugene Young, Susan Stone, Judith Atwood
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Publication number: 20070154939Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.Type: ApplicationFiled: February 26, 2007Publication date: July 5, 2007Applicant: Applera CorporationInventors: Anthony Cerrone, Edward Lakatos, Michael Gambini, Eugene Young, John Atwood, Susan Stone, Judith Atwood
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Publication number: 20070148761Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having vials of reaction ingredients. A beam splitter passes an excitation beam to the vials. An emission beam from the reaction ingredients can be passed by the beam splitter to a detector from which a processor can compute DNA concentration. A reference strip with a plurality of reference emitters can be provided which emits reference beams of different intensity, from which the processor can select an optimum emitter for compensating for drift. Exposure time can be automatically adjusted for keeping within optimum dynamic ranges of the detector and processor. A module of the beam splitter and associated optical filters can be associated with a selected dye, and can be replaceable for different dyes.Type: ApplicationFiled: February 13, 2007Publication date: June 28, 2007Inventors: Anthony Cerrone, Edward Lakatos, Michael Gambini, Eugene Young, Judith Atwood, John Atwood, Susan Stone
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Publication number: 20060199259Abstract: An instrument for monitoring replication of DNA is provided.Type: ApplicationFiled: April 18, 2006Publication date: September 7, 2006Applicant: Applera CorporationInventors: Anthony Cerrone, Edward Lakatos, Michael Gambini, Eugene Young, Susan Stone, Judith Atwood, John Atwood
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Publication number: 20060128009Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.Type: ApplicationFiled: January 17, 2006Publication date: June 15, 2006Inventors: Anthony Cerrone, Edward Lakatos, Michael Gambini, Eugene Young, Susan Stone, Judith Atwood
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Publication number: 20060088444Abstract: In a luminescence detecting apparatus and method for analyzing luminescent samples, luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, an infrared filter, and a camera lens, whereupon a focused image is created by the optics on the camera. The use of an infrared filter suppresses stray IR radiation resulting from plate phosphorescence (which can result in abnormally high backgrounds and/or alteration of the image received by the camera).Type: ApplicationFiled: October 18, 2005Publication date: April 27, 2006Inventors: Michael Gambini, John Voyta, John Atwood, Susan Atwood Stone, Bruce DeSimas, Edward Lakatos, Jeff Levi, Israel Metal, George Sabak, Yongdong Wang
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Publication number: 20030092194Abstract: A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents.Type: ApplicationFiled: December 20, 2002Publication date: May 15, 2003Inventors: Michael R. Gambini, John C. Voyta, John Atwood, Bruce E. DeSimas, Edward Lakatos, Jeff Levi, Israel Metal, George Sabak, Yongdong Wang
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Patent number: 6518068Abstract: A luminescence detecting apparatus and method for analyzing luminescent samples is disclosed. Luminescent samples are placed in a plurality of sample wells in a tray, and the tray is placed in a visible-light impervious chamber containing a charge coupled device camera. The samples may be injected in the wells, and the samples may be injected with buffers and reagents, by an injector. In the chamber, light from the luminescent samples pass through a collimator, a Fresnel field lens, a filter, and a camera lens, whereupon a focused image is created by the optics on the charge-coupled device (CCD) camera. The use of a Fresnel field lens, in combination with a collimator and filter, reduces crosstalk between samples below the level attainable by the prior art. Preferred embodiments of the luminescence detecting apparatus and method disclosed include central processing control of all operations, multiple wavelength filter wheel, and robot handling of samples and reagents.Type: GrantFiled: July 21, 2000Date of Patent: February 11, 2003Assignee: Tropix, Inc.Inventors: Michael R. Gambini, John C. Voyta, John Atwood, Bruce E. DeSimas, II, Edward Lakatos, Jeff Levi, Israel Metal, George Sabak, Yongdong Wang