Abstract: A nutritional supplement composition that enhances the incorporation of calcium and other bone building elements in bone and that prevents bone breakdown, specifically due to the chronic metabolic acidosis that the typical Western diet generates each day. The transcription factor NFKB (Nuclear Factor Kappa B), which underlies some of this physiology, has also been shown to adversely affect fat metabolism. The enzymatic protein complex, AMP Kinase (Adenosine Monophosphate Kinase), a key regulator of energy metabolism, has been shown to reverse the effects of excessive NFKB activity on bone and fat metabolism. The novel nutrients modulate nutrient partitioning and fat metabolism in a human or animal so as to increase oxidation of fat, decrease storage of fat and promote increased storage of glycogen.

Abstract: A nutritional supplement composition that extends the utility of the prior art methods to include enhanced utility for bone health via modulation of the RANK, RANKL, NFKB signaling system and incorporates unrelated, unforeseen benefits on brain health based on the beneficial impact of the same signaling system on brain health thus preventing loss of neurological function and/or normalizing impaired or deteriorating neurological function in humans based on: (1) mitigation of the adverse impact of dysregulated acid-base balance, (2) dysregulation of prostaglandin physiology, (3) abnormalities in RANK, RANKL, NFKB physiology. reversing elevated NFKB, RANK, RANKL signaling. The nutrients that are ideal for the desired result are Honokiol, Magnolol, Beta-caryophyllene, Palmitoylethanolamide, Hesperidin, Schisandrin, Ferulic Acid, Beta-carotene, Lutein, Lycopene, Sulforaphane, and Ellagic Acid.

Abstract: Improved nutraceutical compositions and methods for maintaining healthy calcium metabolism and maintenance of muscle mass. The compositions include a first component selected from the group consisting of a citrate anion, a bicarbonate anion and an acetate anion; a second component selected from the group consisting of a potassium cation, a magnesium cation, a calcium cation, and a sodium cation; and a third component selected from the group consisting of resveratrol, green tea extract, tumeric, basil, sage, thyme, ginger or ginger extract, oregano or oregano extract, rosemary or rosemary extract, hypericum perforatum, glycyrrhiza glabra, plantago lanceolata, quercetin, glycyrrhiza glabra, and gingko biloba. The compositions may be administered conventionally in tablets or capsules, as a dietary supplement, or be delivered in a food additive, food or beverage product, functional food, medical food, botanical drug, over-the-counter (OTC) drug, or any other category of product for human or animal consumption.

Abstract: A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

Abstract: A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

Abstract: A nutritional supplement composition for normalizing impaired or deteriorating neurological function in humans is composed of: at least one agent which promotes synthesis of ATP and/or creatine phosphate in the body, at least one antioxidant for scavenging free radicals in at least one pathway in the body; at least one agent for normalizing or maintaining membrane function and structure in the body; at least one agent for normalizing or maintaining normal neurotransmitter function in the body; at least one agent for down-regulating cortisol action; and at least one agent for suppressing activation of apoptotic pathways in the body.

Abstract: A combination of chemical agents reduces reductive stress by limiting the accumulation of high-energy electrons potentially available to the electron transport chain. A method of metabolic uncoupling therapy comprises: analyzing a specific physiologic process involving reductive stress; identifying a plurality of MUT agents that modulate metabolic pathways by influencing electron flux; and formulating a combination of MUT agents that limits the accumulation of high-energy electrons potentially available to the electron transport chain.

Abstract: A nutritional supplement composition for normalizing impaired or deteriorating neurological function in humans is composed of: at least one agent which promotes synthesis of ATP and/or creatine phosphate in the body, at least one antioxidant for scavenging free radicals in at least one pathway in the body; at least one agent for normalizing or maintaining membrane function and structure in the body; at least one agent for normalizing or maintaining normal neurotransmitter function in the body; at least one agent for down-regulating cortisol action; and at least one agent for suppressing activation of apoptotic pathways in the body.