Patents by Inventor Edward M. Nolan

Edward M. Nolan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
    Patent number: 7054685
    Abstract: A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.
    Type: Grant
    Filed: August 8, 2002
    Date of Patent: May 30, 2006
    Assignee: Genetronics, Inc.
    Inventors: Steve Dimmer, Gunter Hofmann, Daniel Holt, Gurvinder Nanda, Edward M. Nolan
  • Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
    Patent number: 6678558
    Abstract: A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: January 13, 2004
    Assignee: Genetronics, Inc.
    Inventors: Steve Dimmer, Gunter Hofmann, Daniel Holt, Gurvinder Nanda, Edward M. Nolan
  • Method and apparatus for reducing electroporation-mediated muscle reaction and pain response
    Publication number: 20020193833
    Abstract: A method for delivery of an agent to a cell using electroporation is disclosed. The method includes positioning a first electrode and a second electrode such that an electrical signal passed between the first electrode and the second electrode passes through the cell. The method also includes passing an electrical signal between the first electrode and the second electrode, the electrical signal having a frequency greater than about 10 kHz. In one embodiment of the method, the electrical signal has a bipolar waveform. In another embodiment of the method, the electrodes are positioned at a treatment site, e.g., a tumor, for in vivo delivery of an agent.
    Type: Application
    Filed: August 8, 2002
    Publication date: December 19, 2002
    Applicant: GENETRONICS, INC.
    Inventors: Steve Dimmer, Gunter Hofmann, Daniel Holt, Gurvinder Nanda, Edward M. Nolan
  • FACS assisted methods for introducing individual chromosomes into cells
    Publication number: 20020019052
    Abstract: The present invention provides methods and apparatus for the delivery of at least one chromosome into a cell. Invention methods and apparatus employ FACS or MACS technology for rapidly processing cells and for confirming the introduction of chromosome(s) into a cell. The introduction of the chromosome(s) into the cell is mediated by one or more of a laser, a linear accelerator or electrically induced fusion of a cell and encapsulated chromosome(s). Invention methods provide for the rapid and reliable processing associated with FACS and MACS technology to process thousands of cells a minute, thereby enabling large scale gene transfer.
    Type: Application
    Filed: October 10, 2001
    Publication date: February 14, 2002
    Applicant: GENETRONICS, INC.
    Inventors: Edward M. Nolan, Dietmar P. Rabussay, Gunter A. Hofmann