Abstract: Disclosed herein are catheters having multiple coil layers, and associated systems and methods. In some embodiments, a catheter includes an inner liner, a plurality of wires over the inner liner, and an outer sheath over the wires. The wires are coiled about a longitudinal axis of the catheter in a first direction to form a first coil layer over the inner liner, and the wires are coiled about the longitudinal axis in a second direction, opposite the first direction, over the first coil layer to form a second coil layer over the first coil layer. The wires each include a continuous/self-terminating end portion wherein the wire switches from the first direction to the second direction and transitions from the inner coil layer to the outer coil layer.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, engaging an interventional device of a catheter system with clot material in a blood vessel and withdrawing the interventional device and the portion of the clot material through a guide catheter. In some embodiments, the catheter system can include an attachment/valve member coupled to a proximal portion of the guide catheter, and the method can include unsealing the attachment/valve member to facilitate withdrawing the interventional device through the attachment/valve member without significant retention of clot material within the attachment/valve member. The method can further include resealing and aspirating the guide catheter before advancing another interventional device to the clot material to again engage and remove clot material from the blood vessel.

Abstract: Disclosed is a method and system for a single broadband portal where all content may be delivered to users of varied electronic devices. An example embodiment (i) provides a user interface for enabling user selection of media contents per varied electronic devices, each varied electronic device having a respective platform, the user interface indicating one or more different possible media contents; (ii) accepts from a user requests for distribution service to any of the varied electronic devices of the user, the requests specifying a user desired media content; (ii) locates the user desired media content from a plurality of storage modules; (iv) transmits the user desired media content to at least one of the varied electronic devices of the user; and (v) tracks the transmission of the user desired media content for billing purposes.

Abstract: During text-to-speech processing, a speech model creates output audio data, including speech, that corresponds to input text data that includes a representation of the speech. A spectrogram estimator estimates a frequency spectrogram of the speech; the corresponding frequency-spectrogram data is used to condition the speech model. A plurality of acoustic features corresponding to different segments of the input text data, such as phonemes, syllable-level features, and/or word-level features, may be separately encoded into context vectors; the spectrogram estimator uses these separate context vectors to create the frequency spectrogram.

Abstract: Disclosed herein are clot treatment systems and associated devices and methods. In some embodiments, a clot treatment system includes a catheter having a shaped distal portion configured to access a patient's left atrial appendage. The shaped distal portion of the catheter can be aligned with and/or positioned within the patient's left atrial appendage and used to aspirate clot material therefrom. The clot treatment system can further include a clot capture device configured to at least partially cover an opening of the left atrial appendage. For example, the clot capture device can be aligned with, positioned against, and/or inserted at least partially through an ostium of the patient's left atrial appendage to catch any clot material that breaks free from the left atrial appendage.

Abstract: Disclosed herein are dilators for vascular access systems, and associated devices and methods. In some embodiments, a dilator includes an elongate body having a diameter that is generally constant or uniform along the length of the body. The diameter can be sized to correspond with a catheter of a vascular access system, such that the dilator can be positioned within the catheter with little or no gaps or spacing between the dilator and an interior of the catheter. Additionally, or alternatively, the body of the dilator can include multiple body regions, each having one or more respective mechanical properties. In these and other embodiments, the dilator can be configured to interface with at least a portion of the vascular access system. For example, the dilator can include one or more notches configured to couple the dilator to the vascular access system via a valve of the vascular access system.

Abstract: Disclosed herein are clot treatment systems with filtering syringes, and associated devices and methods. The filtering syringe can be coupled to a catheter subsystem insertable within a patient. The filtering syringe can aspirate material (e.g., clot material, blood, etc.) from a patient via the catheter subsystem. The filtering syringe can include a plunger assembly, and the plunger assembly can include one or more filters. Each of the filters can be configured to (i) allow at least a first portion of aspirated material (e.g., blood) to pass through at least one of the filters, and (ii) prevent at least a second portion of the aspirated material (e.g., clot material) from passing through at least one of the filters. In some embodiments, the filtering syringe is fluidly coupled to a filtered material subsystem that can fluidly couple the filtering syringe to the patient or another suitable fluid outflow location.

Abstract: A speech model includes a sub-model corresponding to a vocal attribute. The speech model generates an output waveform using a sample model, which receives text data, and a conditioning model, which receives text metadata and produces a prosody output for use by the sample model. If, during training or runtime, a different vocal attribute is desired or needed, the sub-model is re-trained or switched to a different sub-model corresponding to the different vocal attribute.

Abstract: During text-to-speech processing, a speech model creates output audio data, including speech, that corresponds to input text data that includes a representation of the speech. A spectrogram estimator estimates a frequency spectrogram of the speech; the corresponding frequency-spectrogram data is used to condition the speech model. A plurality of acoustic features corresponding to different segments of the input text data, such as phonemes, syllable-level features, and/or word-level features, may be separately encoded into context vectors; the spectrogram estimator uses these separate context vectors to create the frequency spectrogram.

Abstract: Disclosed herein are vascular access systems with dilator locking mechanisms, and associated devices and methods. In some embodiments, the dilator locking mechanisms include a first cap coupled to a dilator component and a second cap coupled to the vascular access system. The first cap can include one or more locking members. The second cap can include one or more locking features, each configured to be releasably coupled to one of the locking members. In operation, the dilator component can be inserted into the vascular access system, and at least a portion of one or more of the locking members can be aligned with and inserted into the corresponding locking feature to, e.g., couple the first cap and the second cap. The interaction between first and second caps when coupled can at least partially prevent the dilator from moving relative to the vascular access system.

Abstract: Disclosed herein are aspiration catheters having grooved inner surfaces for removing clot material from the vasculature of a patient, and associated systems and methods. In some embodiments, an aspiration catheter can include a proximal terminus, a distal terminus, and an inner surface defining a lumen. The inner surface includes at least one groove formed therein and that extends from the distal terminus at least partially toward the proximal terminus. When clot material is aspirated through the aspiration catheter, the at least one groove can provide a leak path past the clot material to improve the ingestion of the clot material through the catheter and inhibit clogging.

Abstract: Disclosed is a method and system for a single broadband portal where all content may be delivered to users of varied electronic devices. An example embodiment (i) provides a user interface for enabling user selection of media contents per varied electronic devices, each varied electronic device having a respective platform, the user interface indicating one or more different possible media contents; (ii) accepts from a user requests for distribution service to any of the varied electronic devices of the user, the requests specifying a user desired media content; (ii) locates the user desired media content from a plurality of storage modules; (iv) transmits the user desired media content to at least one of the varied electronic devices of the user; and (v) tracks the transmission of the user desired media content for billing purposes.

Abstract: During text-to-speech processing, a speech model creates output audio data, including speech, that corresponds to input text data that includes a representation of the speech. A spectrogram estimator estimates a frequency spectrogram of the speech; the corresponding frequency-spectrogram data is used to condition the speech model. A plurality of acoustic features corresponding to different segments of the input text data, such as phonemes, syllable-level features, and/or word-level features, may be separately encoded into context vectors; the spectrogram estimator uses these separate context vectors to create the frequency spectrogram.

Abstract: Disclosed is a method and system for a single broadband portal where all content may be delivered to users of varied electronic devices. An example embodiment (i) provides a user interface for enabling user selection of media contents per varied electronic devices, each varied electronic device having a respective platform, the user interface indicating one or more different possible media contents; (ii) accepts from a user requests for distribution service to any of the varied electronic devices of the user, the requests specifying a user desired media content; (ii) locates the user desired media content from a plurality of storage modules; (iv) transmits the user desired media content to at least one of the varied electronic devices of the user; and (v) tracks the transmission of the user desired media content for billing purposes.

Abstract: A text-to-speech (TTS) system that is capable of considering characteristics of various portions of text data in order to create continuity between segments of synthesized speech. The system can analyze text portions of a work and create feature vectors including data corresponding to characteristics of the individual portions and/or the overall work. A TTS processing component can then consider feature vector(s) from other portions when performing TTS processing on text of a first portion, thus giving the TTS component some intelligence regarding other portions of the work, which can then result in more continuity between synthesized speech segments.

Abstract: Disclosed is a method and system for a single broadband portal where all content may be delivered to users of varied electronic devices. An example embodiment (i) provides a user interface for enabling user selection of media contents per varied electronic devices, each varied electronic device having a respective platform, the user interface indicating one or more different possible media contents; (ii) accepts from a user requests for distribution service to any of the varied electronic devices of the user, the requests specifying a user desired media content; (ii) locates the user desired media content from a plurality of storage modules; (iv) transmits the user desired media content to at least one of the varied electronic devices of the user; and (v) tracks the transmission of the user desired media content for billing purposes.

Abstract: During text-to-speech processing, a speech model creates output audio data, including speech, that corresponds to input text data that includes a representation of the speech. A spectrogram estimator estimates a frequency spectrogram of the speech; the corresponding frequency-spectrogram data is used to condition the speech model. A plurality of acoustic features corresponding to different segments of the input text data, such as phonemes, syllable-level features, and/or word-level features, may be separately encoded into context vectors; the spectrogram estimator uses these separate context vectors to create the frequency spectrogram.

Abstract: Automatically-locking syringes are disclosed herein. A syringe in accordance with embodiments of the present technology can include (i) a barrel, (ii) a plunger slidably positioned within the barrel, and (iii) a lock plate coupled to the barrel. The plunger also extends through an opening in the lock plate, and a biasing member is configured to bias the lock plate to a locking position. When the plunger is moved from a depressed position to a withdrawn position, the lock feature engages the lock plate to drive the lock plate away from the locking position to thereby permit the lock feature to pass through the opening in the lock plate. After the lock feature passes through the opening, the biasing member drives the lock plate to the locking position to inhibit movement of the plunger from the withdrawn position to the depressed position.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. In one embodiment, a funnel catheter assembly includes an outer shaft and an inner shaft extending through and coaxial with the outer shaft. An expandable funnel can be coupled to a distal portion of the inner shaft. The funnel catheter assembly further includes a control assembly operably coupled to the proximal portion of the outer shaft and configured to move the outer shaft between a first position and a second position. In the first position, the outer shaft is positioned at least partially over the funnel to constrain the funnel in a compressed state. In the second position, the outer shaft is retracted proximally relative to the funnel such that the funnel can expand to an expanded state.

Abstract: A speech model is trained using multi-task learning. A first task may correspond to how well predicted audio matches training audio; a second task may correspond to a metric of perceived audio quality. The speech model may include, during training, layers related to the second task that are discarded at runtime.