Patents by Inventor Edward Micinski
Edward Micinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10899783Abstract: The present invention relates to a method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate wherein said method includes steps of: (i) combining the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide to afford a mixture; (ii) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4,1? and 6? positions thereof; and (iii) quenching the product stream of (ii) to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of said tertiary amide is removed by extraction into a solvent in which said tertiary amide is at least partially soluble.Type: GrantFiled: June 24, 2019Date of Patent: January 26, 2021Assignee: TATE & LYLE TECHNOLOGY LIMITEDInventors: David Dentel, Thomas Eilers, Edward Micinski
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Publication number: 20190309005Abstract: The present invention relates to a method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate wherein said method includes steps of: (i) combining the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide to afford a mixture; (ii) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1? and 6? positions thereof; and (iii) quenching the product stream of (ii) to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of said tertiary amide is removed by extraction into a solvent in which said tertiary amide is at least partially soluble.Type: ApplicationFiled: June 24, 2019Publication date: October 10, 2019Applicant: Tate & Lyle Technology LimitedInventors: David DENTEL, Thomas EILERS, Edward MICINSKI
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Patent number: 10370398Abstract: The present invention relates to a method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate wherein said method includes steps of: (i) combining the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide to afford a mixture; (ii) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1? and 6? positions thereof; and (iii) quenching the product stream of (ii) to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of said tertiary amide is removed by extraction into a solvent in which said tertiary amide is at least partially soluble.Type: GrantFiled: June 20, 2017Date of Patent: August 6, 2019Assignee: TATE & LYLE TECHNOLOGY LIMITEDInventors: David Dentel, Thomas Eilers, Edward Micinski
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Publication number: 20170369518Abstract: The present invention relates to a method for the chlorination of a sucrose-6-acylate to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate wherein said method includes steps of: (i) combining the sucrose-6-acylate with a chlorinating agent in a reaction vehicle comprising a tertiary amide to afford a mixture; (ii) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1? and 6? positions thereof; and (iii) quenching the product stream of (ii) to produce a 4,1?,6?-trichloro-4,1?,6?-trideoxy-galactosucrose-6-acylate; wherein before said quenching, a portion of said tertiary amide is removed by extraction into a solvent in which said tertiary amide is at least partially soluble.Type: ApplicationFiled: June 20, 2017Publication date: December 28, 2017Applicant: Tate & Lyle Technology LimitedInventors: David DENTEL, Thomas EILERS, Edward MICINSKI
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Patent number: 9073959Abstract: A process for the production of sucrose-6-ester is disclosed. The process includes, in order, the steps of: (a) providing a first reaction mixture including sucrose, a reaction vehicle, and an organotin-based acylation promoter; (b) removing water from the first reaction mixture to afford a second reaction mixture that is substantially free from water; and (c) adding a carboxylic acid anhydride to the second reaction mixture to afford a third reaction mixture, thereby producing a sucrose-6-ester; wherein: during step (b), the removing of water includes distillation of water with the reaction vehicle using an apparatus supplying a heat flux of from 500 to 25,000 BTU/hrft2 (1577 to 78865 W/m2) selected from the group consisting of wiped film evaporators, agitated thin film evaporators, falling film evaporators and rising film evaporators.Type: GrantFiled: October 11, 2010Date of Patent: July 7, 2015Assignee: TATE & LYLE TECHNOLOGY LIMITEDInventors: Edward Micinski, David Coleman
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Patent number: 8921540Abstract: A method for the preparation of a sucrose-6-ester is disclosed. In a first step of the method, sucrose in a polar aprotic solvent is reacted with an organotin-based acylation promoter. The water of reaction is removed at a temperature that does not exceed about 80° C. In one aspect, the water is removed by distillation of part of the polar aprotic solvent at reduced pressure. In a second step, a carboxylic acid anhydride is added. In one aspect, the resulting reaction mixture is maintained at a temperature of 10° C. or less for a period of time sufficient to produce a sucrose-6-ester. The sucrose-6-ester can be converted to sucralose.Type: GrantFiled: October 11, 2010Date of Patent: December 30, 2014Assignee: Tate & Lyle Technology LimitedInventors: Edward Micinski, David Coleman, James Edwin Wiley, Jr.
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Patent number: 8796446Abstract: A method of removing a carboxylic acid from a liquid including a tertiary amide solvent includes: forming an extraction medium including an acid-extracting tin species and an extraction solvent that is immiscible with the tertiary amide solvent; subsequently contacting the liquid with the extraction medium, forming a phase including a de-acidified tertiary amide solvent and a phase including the extraction solvent; and removing the phase including the extraction solvent, to afford a liquid including the de-acidified tertiary amide solvent. The acid-extracting tin species is one or more tin species obtained by reaction of a di(hydrocarbyl) tin oxide with less than one equivalent of a carboxylic acid, or tin species obtainable by reaction of a 1,3-diacyloxy-1,1,3,3-tetra-(hydrocarbyl)distannoxane with an aqueous base. A method of preparing a sucralose-6-acylate includes uses the foregoing method to remove a carboxylic acid from a liquid including a tertiary amide solvent and the sucralose-6-acylate.Type: GrantFiled: May 3, 2012Date of Patent: August 5, 2014Assignee: Tate & Lyle Technology LimitedInventors: David T. Coleman, Edward Micinski, James Edwin Wiley, Jr., Thomas A. Eilers, David A. Dentel
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Publication number: 20120289693Abstract: A method of removing a carboxylic acid from a liquid including a tertiary amide solvent includes: A) forming an extraction medium including an acid-extracting tin species and an extraction solvent that is immiscible with the tertiary amide solvent; B) subsequently contacting the liquid with the extraction medium, forming a phase including a de-acidified tertiary amide solvent and a phase including the extraction solvent; and C) removing the phase including the extraction solvent, to afford a liquid including the de-acidified tertiary amide solvent. The acid-extracting tin species is one or more tin species obtainable by reaction of a di(hydrocarbyl)tin oxide with less than one equivalent of a carboxylic acid, tin species obtainable by reaction of a 1,3-diacyloxy-1,1,3,3-tetra-(hydrocarbyl)distannoxane with an aqueous base.Type: ApplicationFiled: May 3, 2012Publication date: November 15, 2012Applicant: Tate & Lyle Technology LimitedInventors: David T. Coleman, Edward Micinski, James Edwin Wiley, JR., Thomas A. Eilers, David A. Dentel
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Patent number: 8212022Abstract: A process for the purification of aqueous feed streams containing sucralose and/or sucralose 6-esters includes, providing an aqueous feed stream including the sucralose and/or sucralose 6-esters, concentrating the aqueous feed stream to form a concentrated aqueous feed stream containing at least 10 wt % total carbohydrates and extracting the concentrated aqueous feed stream with an organic solvent and producing an organic extract and an aqueous extract, in which the organic solvent is immiscible with water, and in which the carbohydrate preferentially passes into the organic extract.Type: GrantFiled: April 1, 2009Date of Patent: July 3, 2012Assignee: Tate & Lyle Technology LimitedInventors: Edward Micinski, James Edwin Wiley, Jr.
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Publication number: 20110087018Abstract: A method for the preparation of a sucrose-6-ester is disclosed. In a first step of the method, sucrose in a polar aprotic solvent is reacted with an organotin-based acylation promoter. The water of reaction is removed at a temperature that does not exceed about 80° C. In one aspect, the water is removed by distillation of part of the polar aprotic solvent at reduced pressure. In a second step, a carboxylic acid anhydride is added. In one aspect, the resulting reaction mixture is maintained at a temperature of 10° C. or less for a period of time sufficient to produce a sucrose-6-ester. The sucrose-6-ester can be converted to sucralose.Type: ApplicationFiled: October 11, 2010Publication date: April 14, 2011Applicant: Tate & Lyle Technology LimitedInventors: Edward Micinski, David Coleman, James Edwin Wiley, JR.
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Publication number: 20110087019Abstract: A process for the production of sucrose-6-ester is disclosed. The process includes, in order, the steps of: (a) providing a first reaction mixture including sucrose, a reaction vehicle, and an organotin-based acylation promoter; (b) removing water from the first reaction mixture to afford a second reaction mixture that is substantially free from water; and (c) adding a carboxylic acid anhydride to the second reaction mixture to afford a third reaction mixture, thereby producing a sucrose-6-ester; wherein: during step (b), the removing of water includes distillation of water with the reaction vehicle using an apparatus supplying a heat flux of from 500 to 25,000 BTU/hrft2 (1577 to 78865 W/m2) selected from the group consisting of wiped film evaporators, agitated thin film evaporators, falling film evaporators and rising film evaporators.Type: ApplicationFiled: October 11, 2010Publication date: April 14, 2011Applicant: Tate & Lyle Technology LimitedInventors: Edward Micinski, David Coleman
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Publication number: 20100081803Abstract: A process for the purification of aqueous feed streams containing sucralose comprises: a) extracting an aqueous feed stream comprising sucralose with a first organic solvent and producing a first organic extract and a first aqueous extract, in which the organic solvent is immiscible with water, and a portion of the sucralose passes into the first organic extract; b) optionally extracting the first organic extract with an aqueous solvent to produce a second organic extract and a second aqueous extract, in which the sucralose preferentially passes into the second aqueous extract, and in which the second aqueous extract is recycled to step a); c) concentrating the first aqueous extract to form a concentrated aqueous feed stream; and d) extracting the concentrated aqueous feed stream with a second organic solvent and producing a third organic extract and a third aqueous extract, in which the second organic solvent is immiscible with water, and in which the sucralose preferentially passes into the third organicType: ApplicationFiled: April 1, 2009Publication date: April 1, 2010Applicant: Tate & Lyle Technology LimitedInventors: Edward Micinski, James Edwin Wiley, JR.
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Publication number: 20090281295Abstract: A process for the purification of sucralose in sucralose-containing feed streams is disclosed. The process includes multiple liquid-liquid extraction steps; optionally, a concentration step; multiple crystallization steps; optionally, a chromatography step; and various recycle steps.Type: ApplicationFiled: April 2, 2009Publication date: November 12, 2009Applicant: Tate & Lyle Technology LimitedInventors: Edward Micinski, James Edwin Wiley, JR., Duane A. Leinhos, Mark R. Huber
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Patent number: 7049435Abstract: The present invention relates to novel extractive methods for purifying sucralose. The present invention also relates to compositions comprising the sucralose preparations made by the methods of the present invention.Type: GrantFiled: March 8, 2002Date of Patent: May 23, 2006Assignee: Tate & Lyle Public Limited CompanyInventors: Steven J. Catani, Nicholas M. Vernon, David Saul Neiditch, James Edwin Wiley, Jr., Edward Micinski
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Patent number: 6998480Abstract: This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.Type: GrantFiled: March 8, 2002Date of Patent: February 14, 2006Assignee: Tate & Lyle Public Limited CompanyInventors: Steven J. Catani, James E. Wiley, Nicholas M. Vernon, Carolyn M. Merkel, Edward Micinski
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Publication number: 20050170069Abstract: The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.Type: ApplicationFiled: March 25, 2005Publication date: August 4, 2005Inventors: Nicholas Vernon, Edward Micinski, Steven Catani, Juan Navia
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Patent number: 6890581Abstract: The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.Type: GrantFiled: April 5, 2002Date of Patent: May 10, 2005Assignee: Tate & Lyle Public Limited CompanyInventors: Nicholas M. Vernon, Edward Micinski, Steven J. Catani, Juan L. Navia
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Publication number: 20030190395Abstract: The present invention relates to novel methods for stabilizing aqueous deacylation, via use of buffers in the production of sucralose. The present invention provides a process for producing sucralose from an acyl-sucralose compound whereby the acyl-sucralose compound is deacylated in the presence of a buffering agent, which stabilizes the pH of the feed mixture and decreases the accumulation of undesired anhydro compounds. Further, the present invention provides a process whereby the acyl-sucralose compound is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination feed mixture. An aqueous solution of sucralose including salts and other compounds is produced, from which sucralose is recovered by extraction and purified by crystallization.Type: ApplicationFiled: April 5, 2002Publication date: October 9, 2003Inventors: Nicholas M. Vernon, Edward Micinski, Steven J. Catani, Juan L. Navia
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Publication number: 20030171575Abstract: This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.Type: ApplicationFiled: March 8, 2002Publication date: September 11, 2003Inventors: Steven J. Catani, James E. Wiley, Nicholas M. Vernon, Carolyn M. Merkel, Edward Micinski
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Publication number: 20030171574Abstract: The present invention relates to novel extractive methods for purifying sucralose. The present invention also relates to compositions comprising the sucralose preparations made by the methods of the present invention.Type: ApplicationFiled: March 8, 2002Publication date: September 11, 2003Inventors: Steven J. Catani, Nicholas M. Vernon, David Saul Neiditch, James Edwin Wiley, Edward Micinski