Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: There is provided a fan assembly comprising a motor-driven impeller arranged to generate an airflow, an air outlet arranged to emit the airflow, a plurality of sensors arranged to measure a value for each of a plurality of air quality characteristics, a display and a processor. The processor is configured to receive measured values for each of the plurality of air quality characteristics, identify one of a corresponding set of intervals within which the measured value falls and select an air quality index value associated with the identified interval. The processor is then configured to identify the highest of the selected air quality index values as a current overall air quality index value and to cause the display to display a time series plot of the current air quality index value and a number of preceding air quality index values.

Abstract: Methods, systems, and apparatus for brain tractography by shading fiber bundles. In one aspect, a method includes forwarding patient brain data for presentation to a user; receiving, from the user, a selection of a brain parcel in response to presentation of the patient brain data; forwarding, for display to the user, tract health data comprising i) tract data for tracts connected to the brain parcel and ii) at least one metric for the tracts, the metric reflecting the health of the tracts; and taking an action in response to forwarding the tract health data.

Abstract: A locking power cord receptacle configured to receive an electric power cord plug that includes a ground pin comprises a base receptacle and a locking assembly. The base receptacle includes a first female connector, a second female connector, and a ground female connector positioned on an upper surface and arranged to receive the power cord plug. The base receptacle further includes a body cavity on the upper surface. The locking assembly has a locked state in which the locking assembly blocks access to the base receptacle and an unlocked state in which the power cord plug can be plugged in to the base receptacle. The locking assembly includes a locking cover and a locking component. The locking cover includes a disc and a sleeve coupled to the disc and the base receptacle. The locking component is retained in the body cavity and has a locked configuration and an unlocked configuration.

Abstract: A wearable air purifier including a headgear; an air purifier assembly, the air purifier assembly configured to generate a filtered airflow from an outlet aperture thereof; and a nozzle assembly connected to the headgear by a hinge assembly. The nozzle assembly includes an inlet aperture for receiving the filtered airflow from the outlet aperture of the air purifier assembly and an air outlet for emitting the filtered airflow from the nozzle assembly. The hinge assembly is configured such that the nozzle assembly is movable relative to the headgear between first and second configurations, filtered airflow is emitted from the air outlet in the first configuration and filtered airflow is not emitted from the air outlet in the second configuration.

Abstract: A method and system of monitoring crimp quality of a crimp terminal in a hydraulic crimping apparatus. The method includes: determining a pressure of a hydraulic fluid supplied to a hydraulic crimping head of the hydraulic crimping apparatus; determining a flow of the hydraulic fluid supplied to the hydraulic crimping head of the hydraulic crimping apparatus; and analyzing the pressure and the flow of the hydraulic fluid to determine if a crimp is defective or not defective.

Abstract: A computer based system and method for inventory management, cost savings delivery and decision making is disclosed. A global data warehouse contains a cost savings delivery mechanism CSD-M that is configured to receive information from a business intelligence module to create cost savings documentation that identifies and quantifies cost savings that are realized by use of an inventory management system and potential cost saving opportunities that may be realized by use of supply chain and operational cost savings programs.

Abstract: A method and system of monitoring crimp quality of a crimp terminal in a hydraulic crimping apparatus. The method includes: determining a pressure of a hydraulic fluid supplied to a hydraulic crimping head of the hydraulic crimping apparatus; determining a flow of the hydraulic fluid supplied to the hydraulic crimping head of the hydraulic crimping apparatus; and analyzing the pressure and the flow of the hydraulic fluid to determine if a crimp is defective or not defective.

Abstract: A computer based system and method for inventory management, cost savings delivery and decision making is disclosed. A global data warehouse contains a cost savings delivery mechanism CSD-M that is configured to receive information from a business intelligence module to create cost savings documentation that identifies and quantifies cost savings that are realized by use of an inventory management system and potential cost saving opportunities that may be realized by use of supply chain and operational cost savings programs.

Abstract: The present disclosure relates to novel fullerene derivatives, positive and negative photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for high speed, fine pattern processing using, for example, ultraviolet radiation, extreme ultraviolet radiation, beyond extreme ultraviolet radiation, X-rays, electron beam and other charged particle rays.

Abstract: The present disclosure relates to novel fullerene derivatives, positive and negative photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for high speed, fine pattern processing using, for example, ultraviolet radiation, extreme ultraviolet radiation, beyond extreme ultraviolet radiation, X-rays, electron beam and other charged particle rays.

Abstract: The present disclosure relates to novel methanofullerene derivatives, negative-type photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for fine pattern processing using, for example, ultraviolet radiation, beyond extreme ultraviolet radiation, extreme ultraviolet radiation, X-rays and charged particle rays. Negative photosensitive compositions are also disclosed.

Abstract: The present disclosure relates to novel methanofullerene derivatives, negative-type photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for fine pattern processing using, for example, ultraviolet radiation, beyond extreme ultraviolet radiation, extreme ultraviolet radiation, X-rays and charged particle rays.

Abstract: A system, a method, a device, and a computer program product for single sheet planning of business objects are provided. A trade promotion data relating to at least one product is generated. Based on the generated trade promotion data, data stored in a database is queried. The data relates to at least one parameter associated with the generated trade promotion data.

Abstract: The present disclosure relates to novel methanofullerene derivatives, negative-type photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for fine pattern processing using, for example, ultraviolet radiation, beyond extreme ultraviolet radiation, extreme ultraviolet radiation, X-rays and charged particle rays. Negative photosensitive compositions are also disclosed.

Abstract: The present disclosure relates to novel methanofullerene derivatives, negative-type photoresist compositions prepared therefrom and methods of using them. The derivatives, their photoresist compositions and the methods are ideal for fine pattern processing using, for example, ultraviolet radiation, beyond extreme ultraviolet radiation, extreme ultraviolet radiation, X-rays and charged particle rays.

Abstract: A system and method are described herein that provide for saving retrieved business objects locally in a calendar application of a local device for access during an offline mode. Business objects may be retrieved from the backend system, whereupon a plurality of actions are performed upon the retrieved business objects, such as performing searches or viewing related analytics. Detail information about the business objects, such as business object attributes and corresponding analytics are stored locally in the memory of the mobile device running the application. This is enabled by a save feature which triggers the downloading of all related information from a backend system and saving locally on the mobile device. A user may subsequently access the saved business data in environments where there is no online connectivity.

Abstract: A system, method, and computer program product for selecting single or multiple data entities, based on selection of representative items in a graphical user interface via a user input gestural trajectory. Embodiments display items representing data entities, some of which may be selected by a user for further processing by crossing or surrounding the items with a pointing device, such as a mouse, or stylus or fingertip via a touchscreen device. Selected items are visually highlighted in the interface, and the data entities they represent are added to a cache table depicted in a separate summary box. The box includes controls for fast and efficient data entity selection and deselection, display of related criteria, as well as data entity approval and disapproval, and editing capability.

Abstract: Scale(s) on one or more axes may be displayed on a graphical user interface. The scale(s) may present a range of values associated with business object attribute(s). Visual representation(s) associated with business object(s) may be displayed on the graphical user interface. The visual representation(s) may be positioned relative to the scale(s). In response to activation of a grouping mechanism, the visual representation(s) may be moved to a first area in the graphical user interface. The business object(s) associated with the visual representation(s) may include business object attribute value(s) in common with other business objects visually represented in the first area.