Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: A filter element includes a construction of pleated filter media defining an interior volume. First and second opposite end caps are secured to opposite ends of the filter media. A support structure supports the filter media and is operably oriented in the interior volume. The support structure extends from the first opposing interior face to the second opposing interior face. The support structure is provided to extend less than a full extension between the first end cap and second end cap.

Abstract: One or more wheel apparatuses are provided. The wheel apparatus comprises one or more rigid climbing members that extend to the outer perimeter of the wheel apparatus and are configured to maintain shape and/or relative position over all surfaces the wheel apparatus encounters. The wheel apparatus comprises one or more selective flex zones located adjacent to rigid climbing members, constructed to be passively compressed when the wheel apparatus encounters an obstacle in the path of the wheel apparatus. The wheel apparatus comprises one or more support zones located adjacent to selective flex zones that provide support for smooth rotary motion when not traversing obstacles.

Abstract: Requests for content are received by a server from one or more remote devices. The server retrieves the content and renders it in a virtual client. The content is delivered to the one or more remote devices according to one of a plurality of delivery modes according to a detected usage of the content on the one or more remote devices. The delivery mode for the same content may change dynamically in response to changes in usage. The delivery modes may include providing an image of the content, a hybrid of an image with computer code defining operation of one or more interface elements of the content, an image of the content with computer code instructing the retrieval of video content directly from a source, and an image of the content followed by partial updates to the image in response to changes in the content.

Abstract: Methods for imaging stationary targets, including thrombi, are disclosed. The methods allow the imaging of stationary targets in areas of the body subject to physiologic motion.

Abstract: Methods for imaging stationary targets, including thrombi, are disclosed. The methods allow the imaging of stationary targets in areas of the body subject to physiologic motion.

Abstract: A brake assembly capable of providing a park/emergency brake facility and a service brake facility acting on the same friction pad or friction pad pair. The assembly includes a rotatable disc rotor, and at least one friction pad adapted for movement towards a braking surface of the disc rotor to provide a braking effect. The assembly further includes a first brake activating means to provide the park/emergency brake facility operable selectively to urge said one friction pad towards the braking surface of the disc rotor, a second brake activating means to provide a service brake facility selectively operable independently of the first brake activating means to urge the one friction pad towards the braking surface of the disc rotor. A third means normally acts to prevent the first brake activating means from urging the one friction pad towards the braking surface of the disc rotor.

Abstract: A brake arrangement for a vehicle adapted for connection to an axle end. The brake arrangement includes a rotor disc adapted, in use, to rotate with the axle end and a stationary housing enclosing the rotor disc with one or more seals. A substantially sealed zone is provided within at least part of the stationary housing such that at least a braking effect region of the rotor disc, in use, passes through the substantially sealed zone. At least one friction pad is located adjacent a braking surface of the rotor disc in the braking effect region so as to operationally engage the braking surface during a vehicle braking operation. The stationary housing contains a liquid medium within at least the substantially sealed zone, the brake arrangement being characterized in that the liquid medium has a viscosity of less than 7 centistokes mm2/sec at 100° C.

Abstract: A brake pad includes a friction material with a braking surface to contact a rotor disc. The braking surface has a leading edge relative to rotation of the rotor disc, an opposed trailing edge, and inner and outer circumferentially extending edges joining the leading and trailing edges. A plurality of grooves are formed in the friction material and open onto the braking surface. The grooves are angled from a leading end of the grooves rearwardly relative to a radial line and are curved from their leading end to their trailing end, and form substantially the arc of a circle when viewed in a direction perpendicular to the braking surface.

Abstract: Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidin e.

Abstract: N-(4-Imidazolyl)propyl-N'-heterocyclomethylthioethyl guanidines which are selective histamine H.sub.2 -receptor agonists.

Abstract: Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-cyano-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidin e.

Abstract: Pharmaceutical compositions and methods of inhibiting H-1 and H-2 histamine receptors by administering an antihistamine and an H-2 histamine receptor inhibitor. Exemplary of the antihistamine in the compositions and methods of this invention is mepyramine and exemplary of the H-2 histamine receptor inhibitor is N-methyl-N'-[4-(5)-imidazolyl)butyl]thiourea.