Abstract: These methods, devices, and structures are useful in the field of ophthalmology; the devices and methods relate variously to separating or lifting corneal epithelium from the eye preferably in a substantially continuous layer, placing a lens or other suitable ocular or medical device beneath the epithelial membrane, and to the resulting structures formed by those procedures. The de-epilthelialization devices generally utilize a non-cutting separator or dissector that is configured to separate the epithelium at a naturally occurring cleavage surface in the eye between the epithelium and the corneal stroma (Bowman's membrane), specifically separating in the region of the lamina lucida. The separator or dissector may have a structure that rolls or vibrates (or both) at that cleavage surface or interface during the dissection step. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or a pocket.

Abstract: A variable equalizer apparatus for forward and/or reverse equalizers in an amplifier. The system can include a structure to allow continuous contact of the signal flow as an equalizer is removed; jumpers with fixed resistors and associated capacitors and inductors to produce a variable range over many different values; and/or variable resistance potentiometers with fixed resistors and associated capacitors and inductors to produce a variable range over separate value equalizers.

Abstract: The described device is useful in the field of opthalmology. The devices and methods for using it involve separating or lifting corneal epithelium from the eye in a substantially continuous layer to form a flap or pocket. In particular, the devices generally utilize a non-cutting, oscillating separator or dissector that is configured to separate the epithelium at naturally occurring cleavage surfaces in the eye, particularly between the epithelium and the corneal stroma (Bowman's membrane), specifically separating in the region of the lamina lucida, the separator or dissector having a structure that oscillates at that cleavage surface interface during the dissection step. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or pocket. The epithelium may then be replaced on the cornea after a refractive procedure or placement of an ocular lens on the eye.

Abstract: A sampling member defines a passageway including an inlet opening for reception of a bodily fluid therein, and a wicking member having a first portion coupled with the sampling member adjacent to the inlet opening. The wicking member further includes a second portion displaced from the first portion for initially contacting the bodily fluid. In use the sampling member is placed adjacent to an incision site with the second portion of the wicking member positioned to have the bodily fluid first contact the wicking member and thereby draw the fluid from the incision site to the inlet opening. In related embodiments there is provided a sampling system and method which further includes a lancing device to create the incision and optionally expression members to urge the bodily fluid from the incision, preferably in an integrated unit.

Abstract: Bodily fluid is sampled by causing a lancet mounted in a housing to be displaced toward a skin surface. A vacuum mechanism disposed on the housing is utilized to create a suction in the area to be incised causing bodily fluid to pool. The vacuum mechanism may then be deactivated thereby releasing the vacuum force on the skin, or repeatedly activated and deactivated. After the vacuum device has been utilized, the lancet is advanced to form an incision. The vacuum device may be activated, activated and deactivated, or repeatedly activated and deactivated after forming the incision. The sample may be withdrawn from the incision through a capillary tube.

Abstract: In general, the devices and methods described herein are useful in the field of ophthalmology. More particularly, the described methods and devices are useful in the field of refractive eye procedures, such as may be practiced when lifting or separating a portion of the epithelial layer or forming a pocket in the epithelial layer of the when introducing a contact lens beneath the epithelium or in conjunction with a corrective ocular laser treatment.

Abstract: Described here is a surgical device that typically is used to releasably hold the cornea of a human eye (and hence that eye) in such a way as to modestly deform the cornea and the eye, to maintain the eye's position for procedures upon the epithilial layer of the cornea, and to allow ease of replacement of an epithilial flap should one be produced. It may be used in combination with an epithilial delaminating tool, or an ocular device inserting tool. The stabilization device permits ready access to and creation of flaps or pockets of epithelium for later introduction of correcting lenses (e.g. using an ocular device insertion tool) or subtractive procedures such as LASIK or LASEK, prior to replacement of epithelium over the corrective lens or over the site of laser induced or surgically-induced corrective procedure.

Abstract: The present invention relates to a cell line in which a potassium channel is introduced. More specifically, it is a cell line capable of activating the T-type ?1H calcium channel by depolarization wherein a vector encoding a potassium channel is introduced. Since the cell line of the present invention is available for a high throughput screening of candidate T-type ?1H calcium channel inhibitors, it may accelerate the development of therapeutic agents for diseases related to T-type ?1H calcium channels.

Abstract: A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.

Abstract: An integrated bodily fluid sampling device includes a lancet, a test strip attached to the lancet, and a flexible sheet extending from the test strip. The lancet and the flexible sheet form a gap sized to draw bodily fluid onto the test strip via capillary action. Further, a sampling end portion of the flexible sheet is shaped to enhance capillary action of the sheet. In one form, a removable film covers the lancet and forms a seal with the flexible sheet such that the seal surrounds a lancet tip. In another form, an insulating layer covers a portion of the lancet to prevent electrical interference between the lancet and an electrical testing system on the test strip and ensure an accurate analysis of the bodily fluid.

Abstract: An ocular device applicator for inserting an ocular device beneath a corneal epithelium. The ocular device applicator places an ocular device onto a cornea that has been at least partially delaminated. The ocular device applicator comprises an ocular device holder and a manipulator. In some versions an ocular device may be secured in and/or released from the device by force applied in the holder, or by a releasable adhesive.

Abstract: An ocular device applicator that is a combined delaminating and inserting device configured to partially delaminate the corneal epithelium and to place a corrective ocular device onto the delaminated cornea under the partially delaminated epithelium. The ocular device applicator leaves at least a portion of the delaminated corneal epithelium attached to the cornea. The ocular device applicator comprises an edge and an ocular device holder. In some versions an ocular device may be secured in and/or released from the device by force applied in the holder, or by a releasable adhesive. The ocular device applicator may be oscillated to facilitate delamination of the corneal epithelium and placement of an ocular device.

Abstract: This relates to a lens made of donor corneal tissue suitable for use as a contact lens or an implanted lens, to a method of preparing that lens, and to a technique of placing the lens on the eye. The lens is made of donor corneal tissue that is acellularized by removing native epithelium and keratocytes. These cells optionally are replaced with human epithelium and keratocytes to form a lens that has a structural anatomy similar to human cornea. The ocular lens may be used to correct conditions such as astigmatism, myopia, aphakia, and presbyopia.

Abstract: This relates to a lens made of donor corneal tissue suitable for use as a contact lens or an implanted lens, to a method of preparing that lens, and to a technique of placing the lens on the eye. The lens is made of donor corneal tissue that is acellularized by removing native epithelium and keratocytes. These cells optionally are replaced with human epithelium and keratocytes to form a lens that has a structural anatomy similar to human cornea. The ocular lens may be used to correct conditions such as astigmatism, myopia, aphakia, and presbyopia.

Abstract: This relates to a lens made of donor corneal tissue suitable for use as a contact lens or an implanted lens, to a method of preparing that lens, and to a technique of placing the lens on the eye. The lens is made of donor corneal tissue that is acellularized by removing native epithelium and keratocytes. These cells optionally are replaced with human epithelium and keratocytes to form a lens that has a structural anatomy similar to human cornea. The ocular lens may be used to correct conditions such as astigmatism, myopia, aphakia, and presbyopia.

Abstract: A high speed flexible interconnect cable includes a number of conductive layers and a number of dielectric layers. Conductive signal traces, located on the conductive layers, combine with the dielectric layers to form one or more high speed electrical transmission line structures. The transmission line structure may be realized as a grounded coplanar waveguide structure, a microstrip structure, a stripline structure, or the like. The cable can be coupled to destination components using a variety of connection techniques, e.g., direct bonding to a circuit substrate, direct soldering to a flip chip, mechanical attachment to a component, or integration with a circuit substrate. The cable can also be terminated with any number of known or standardized connector packages, e.g., SMA, GPPO, or V connectors.

Abstract: A device for sampling body fluid, the device comprising, a main body, a lancet disposed within the main body, a carrier disposed within the main body fixedly attached to the lancet, a biasing means in communication with the lancet and the carrier, an annular space disposed within the main body adjacent the lancet, and a means for measuring a body fluid. Wherein the means for measuring the body fluid may include micro-porous test strips, an electronic testing device, an optical/reflectance testing measuring device, or a visual inspection.

Abstract: Bodily fluid is sampled by causing a syringe mounted in a housing to be displaced toward a skin surface. A suction element disposed on the housing is utilized to creates a suction in the area to be incised causing bodily fluid to pool. Additionally, the suction mechanism may be utilized to create a suction in the tube for drawing in bodily fluid through the piercing element and into the tube. The syringe remains in the resulting incision while the surrounding body tissue is stimulated by a stimulator ring to urge bodily fluid toward the incision. Simultaneously, the syringe may be moved relative to the incision to keep the incision open. Such movement of the syringe may comprise reciprocation in the longitudinal or lateral directions, or both. Alternatively, the movement of the syringe may comprise rotation about a longitudinal center line of the syringe, with the pointed end of the syringe being in the shape of one-half of a cone segment.

Abstract: Bodily fluid is sampled by causing a syringe mounted in a housing to be displaced toward a skin surface. A suction element disposed on the housing is utilized to creates a suction in the area to be incised causing bodily fluid to pool. Additionally, the suction mechanism may be utilized to create a suction in the tube for drawing in bodily fluid through the piercing element and into the tube. The syringe remains in the resulting incision while the surrounding body tissue is stimulated by a stimulator ring to urge bodily fluid toward the incision. Simultaneously, the syringe may be moved relative to the incision to keep the incision open. Such movement of the syringe may comprise reciprocation in the longitudinal or lateral directions, or both. Alternatively, the movement of the syringe may comprise rotation about a longitudinal center line of the syringe, with the pointed end of the syringe being in the shape of one-half of a cone segment.

Abstract: These methods, devices, and structures are useful in the field of ophthalmology; the devices and methods relate variously to separating or lifting corneal epithelium from the eye preferably in a substantially continuous layer, placing a lens or other suitable ocular or medical device beneath the epithelial membrane, and to the resulting structures formed by those procedures. The de-epilthelialization devices generally utilize a non-cutting separator or dissector that is configured to separate the epithelium at a naturally occurring cleavage surface in the eye between the epithelium and the corneal stroma (Bowman's membrane), specifically separating in the region of the lamina lucida. The separator or dissector may have a structure that rolls or vibrates (or both) at that cleavage surface or interface during the dissection step. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or a pocket.