Patents by Inventor Edward R. Bacon

Edward R. Bacon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-chelate conjugates
    Patent number: 7608242
    Abstract: A peptide-chelate conjugate with affinity for the ST receptor is disclosed, wherein the chelate is tetradentate. The peptide-chelate conjugate of the invention may be labelled with a radiometal to provide a metal complex. A radiopharmaceutical composition comprising the metal complex is provided. which is suitable for the diagnostic imaging of colorectal cancer. Also provided for in the invention is a kit for the preparation of the radiopharmaceutical preparation.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: October 27, 2009
    Assignee: GE Healthcare Limited
    Inventors: Alan Cuthbertson, Marivi Mendizabal, Mark Dixon, Anthony E. Storey, Edward R. Bacon, Vinay Chandrakant Desai, Sudhakar Kasina, Henry Raphael Wolfe
  • Thio-Substituted Biarylmethanesulfinyl Derivatives
    Publication number: 20090062284
    Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 5, 2009
    Applicant: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, Marie-Edith Gourdel, Greg A. Hostetler, Mohamed Iqbal, Brigitte Lesur, Philippe Louvet, Eric Riguet, Dominique Schweizer, Christophe Yue
  • Bicyclic aromatic sulfinyl derivatives
    Publication number: 20090042907
    Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
    Type: Application
    Filed: June 20, 2008
    Publication date: February 12, 2009
    Applicants: Cephalon, Inc., Cephalon France
    Inventors: Edward R. Bacon, Sankar Chatterjee, Mohamed Iqbal, Brigitte Lesur, Philippe Louvet
  • Thio-substituted biaryl-methanesulfinyl derivatives
    Patent number: 7449481
    Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: November 11, 2008
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, Marie-Edith Gourdel, Greg Hostetler, Mohamed Iqbal, Brigitte Lesur, Philippe Louvet, Eric Riguet, Dominique Schweizer, Christophe Yue
  • Bicyclic aromatic sulfinyl derivatives
    Patent number: 7423176
    Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: September 9, 2008
    Assignees: Cephalon, Inc., Cephalon France
    Inventors: Edward R. Bacon, Sankar Chatterjee, Mohamed Iqbal, Brigitte Lesur, Philippe Louvet
  • Tricyclic aromatic and bis-phenyl sulfinyl derivatives
    Patent number: 7314875
    Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: January 1, 2008
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John A. Gruner, Rabindranath Tripathy
  • Substituted thioacetamides
    Patent number: 7268132
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: September 11, 2007
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo
  • Substituted thioacetamides
    Patent number: 6919367
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: July 19, 2005
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
  • Substituted thioacetamides
    Publication number: 20040116445
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Application
    Filed: November 18, 2003
    Publication date: June 17, 2004
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
  • Enhanced radiation therapy
    Publication number: 20040047804
    Abstract: The invention features new methods of enhanced radiation therapy based on the discovery that by using controlled combinations of (i) specific radiodense compositions, (ii) specific modes of administration of these radiodense compositions, and (iii) specific energy bands and sources of radiation, that the effect of radiation on tumors and other diseased tissues can be effectively and safely enhanced to provide significantly improved radiation therapy.
    Type: Application
    Filed: August 12, 2003
    Publication date: March 11, 2004
    Applicant: The General Hospital Corporation, a Massachusetts corporation
    Inventors: Gerald L. Wolf, Gregory L. McIntire, Edward R. Bacon
  • Substituted thioacetamides
    Patent number: 6670358
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 30, 2003
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
  • Substituted thioacetamides
    Patent number: 6492396
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: December 10, 2002
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Jeffry L. Vaught, Matthew S. Miller
  • Substituted thioacetamides
    Publication number: 20020183334
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Application
    Filed: October 26, 2001
    Publication date: December 5, 2002
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Matthew S. Miller, Rabindranath Tripathy, Jeffry L. Vaught
  • Substituted thioacetamides
    Publication number: 20020045629
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Application
    Filed: May 15, 2001
    Publication date: April 18, 2002
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Jeffry L. Vaught
  • 6-substituted pyrazolo[3,4-d]pyrimidin-4-ones and compositions and methods of use thereof
    Patent number: 5977118
    Abstract: 6-Substituted pyrazolo[3,4-d]pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or hypertension.
    Type: Grant
    Filed: March 26, 1997
    Date of Patent: November 2, 1999
    Assignee: Sanofi
    Inventors: Edward R. Bacon, Sol J. Daum, Baldev Singh
  • 6-aryl pyrazolo ?3,4-d! pyrimidin-4-ones and compositions and methods of use thereof
    Patent number: 5958929
    Abstract: 6-Aryl pyrazolo?3,4-d!pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or hypertension.
    Type: Grant
    Filed: January 30, 1998
    Date of Patent: September 28, 1999
    Assignee: Sanofi
    Inventors: Edward R. Bacon, Baldev Singh
  • 6-aryl pyrazolo?3,4-D! pyrimidin-4-ones and compositions and method of use thereof
    Patent number: 5736548
    Abstract: 6-Aryl pyrazolo?3,4-d!pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or hypertension.
    Type: Grant
    Filed: January 22, 1997
    Date of Patent: April 7, 1998
    Assignee: Sanofi
    Inventors: Edward R. Bacon, Baldev Singh
  • 2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging
    Patent number: 5670136
    Abstract: Compounds having the structure: ##STR1## wherein Q is ##STR2## n is an integer from 0 to 20; R.sup.1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl;R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently H, alkyl, fluoroalkyl, halogen, hydroxy, acylamino, acetamidoalkyl, cyano, sulfonyl, carboxamido or sulfonamido;R.sup.6 is alkyl, cycloalkyl, aryl, or aralkyl; andR.sup.7 is H or --COR.sup.6 are useful as contrast agents in medical diagnostic x-ray imaging compositions and methods.
    Type: Grant
    Filed: January 16, 1996
    Date of Patent: September 23, 1997
    Assignee: NahoSystems L.L.C.
    Inventors: Edward R. Bacon, Sol J. Daum, Kimberly G. Estep
  • 3-amido-triiodophenyl esters as x-ray contrast agents
    Patent number: 5668196
    Abstract: This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 0 to 12m is 1 or 2 ##STR2## R.sup.1 is X and Z are independently H or NR.sup.2 COR.sup.3Y is CO.sub.2, CH.sub.2 O, O or NH andR.sup.2 and R.sup.3 are independently H, alkyl having from 1 to 12 carbon atoms or aryl having from 6 to 11 carbon atoms,This invention further relates to novel contrast agents having the above structure wherein R.sup.1 is ##STR3## R.sup.2 is H and R.sup.3 is CH.sub.3 to x-ray contrast compositions comprising such agents, and to method of x-ray diagnostic imaging utilizing such agents.
    Type: Grant
    Filed: July 10, 1996
    Date of Patent: September 16, 1997
    Assignee: NanoSystems LLC
    Inventors: Shaugnessy Robinson, Edward R. Bacon, Kurt A. Josef
  • Substituted thioacetamides
    Patent number: RE39575
    Abstract: The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
    Type: Grant
    Filed: November 23, 2004
    Date of Patent: April 17, 2007
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, John P. Mallamo, Jeffry L. Vaught, Matthew S. Miller