Patents by Inventor Edward R. Biehl

Edward R. Biehl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
    Patent number: 10093681
    Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: October 9, 2018
    Assignee: Southern Methodist University
    Inventors: Edward R. Biehl, Haribabu Ankati, Sukanta Kamila
  • Quinoxaline compounds and derivatives
    Patent number: 9567305
    Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
    Type: Grant
    Filed: January 20, 2014
    Date of Patent: February 14, 2017
    Assignee: Southern Methodist University
    Inventors: Edward R. Biehl, Haribabu Ankati, Sukanta Kamila
  • Compounds and Derivatives of 2H-Pyrido (3,2-b)(1, 4) Oxazin 3)4H)-Ones as raf Kinase and LRRK2 Inhibitors
    Publication number: 20170008907
    Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
    Type: Application
    Filed: September 23, 2016
    Publication date: January 12, 2017
    Inventors: Edward R. Biehl, Haribabu Ankati, Sukanta Kamila
  • Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
    Patent number: 9493452
    Abstract: The present invention provides pharmaceutical compound of formula: wherein A and B are individually an C or N and R1 is an alkyl and R2 is a substituted phenyl, wherein the substituted phenyl comprises 1 to 3 functional groups and R3-R6 are individually a hydrogen, an amine or a halogen disposed in a pharmaceutical carrier.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: November 15, 2016
    Assignee: Southern Methodist University
    Inventors: Edward R. Biehl, Haribabu Ankati, Sukanta Kamila
  • Methods of Making and Using Thioxothiazolidine and Rhodanine Derivatives as HIV-1 and JSP-1 Inhibitors
    Publication number: 20160250194
    Abstract: The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having HIV-1 or JSP-1 inhibitory activity.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 1, 2016
    Inventors: Edward R. Biehl, Sukanta Kamila, Ted M. Dawson
  • Methods of making and using thioxothiazolidine and rhodanine derivatives as HIV-1 and JSP-1 inhibitors
    Patent number: 9309208
    Abstract: The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having HIV-1 or JSP-1 inhibitory activity.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: April 12, 2016
    Assignees: Southern Methodist University, Johns Hopkins University
    Inventors: Edward R. Biehl, Sukanta Kamila, Ted M. Dawson
  • Quinoxaline Compounds and Derivatives
    Publication number: 20140135494
    Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
    Type: Application
    Filed: January 20, 2014
    Publication date: May 15, 2014
    Applicant: SOUTHERN METHODIST UNIVERSITY
    Inventors: Edward R. Biehl, Haribabu Ankati, Sukanta Kamila
  • 1, 4-benzoxazine compounds and derivatives thereof as therapeutic drugs for the treatment of neurodegenerative conditions
    Patent number: 8680094
    Abstract: The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: March 25, 2014
    Assignees: Board of Regents, The University of Texas System, Southern Methodist University
    Inventors: Santosh R. D'Mello, Edward R. Biehl, Haribabu Ankati, Shashidhar Kumar Akubathini
  • Quinoxaline compounds and derivatives
    Patent number: 8669363
    Abstract: The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: March 11, 2014
    Assignee: Southern Methodist University
    Inventors: Edward R. Biehl, Haribabu Ankati, Sukanta Kamila
  • Methods of Making and Using Thioxothiazolidine and Rhodanine Derivatives as HIV-1 and JSP-1 Inhibitors
    Publication number: 20130253021
    Abstract: The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having HIV-1 or JSP-1 inhibitory activity.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 26, 2013
    Applicants: The Johns Hopkins University, Southern Methodist University
    Inventors: Edward R. Biehl, Sukanta Kamila, Ted M. Dawson
  • 1, 4-Benzoxazine Compounds and Derivatives Thereof as Therapeutic Drugs for the Treatment of Neurodegenerative Conditions
    Publication number: 20120094991
    Abstract: The present invention includes compositions and methods for inhibiting kinase activity to protect against neurodegeneration including diseases such as Alzheimer's disease, Parkinson's disease, or Huntington's disease, and conditions such as ischemic stroke comprising the step of providing the subject with a therapeutically affective amount of 1,4-benzoxazine compounds and derivatives thereof.
    Type: Application
    Filed: August 14, 2009
    Publication date: April 19, 2012
    Applicants: Southerm Methodist University, Board of Regents ,The University of Texas System
    Inventors: Santosh R. D'Mello, Edward R. Biehl, Haribabu Ankati, Shashidar Kuar Akubathini
  • Method for degrading chemical warfare agents using Mn(VII) oxide with-and-without solid support
    Patent number: 8084662
    Abstract: The invention provides a novel method of detoxifying highly toxic chemicals, and treating surfaces contaminated, or potentially contaminated, with toxic chemical agents such as chemical warfare agents and/or industrial toxins. The methods utilizes a novel sorbent compound which comprises Mn(VII) mineral which can be either solid supported or non-solid supported. The Mn(VII) mineral can be provided in a number of different forms including creams, lotions, powders, liquids, slurries and aerosols.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: December 27, 2011
    Assignee: ChK Group Inc.
    Inventors: Rajan K. Vempati, Edward R. Biehl, Ramesh S. Hegde, David Y. Son
  • Enzymatic synthesis of optically pure beta-hydroxy carboxylic acids and their derivatives
    Publication number: 20100267100
    Abstract: The present disclosure is related to systems, compositions, and methods for producing a ?-hydroxy carboxylic acid and/or a ?-hydroxy carboxylic amide in enantiomeric excess (e.g., enantiomerically pure). In some specific example embodiments, a method may include contacting a substrate and/or intermediate with a cyanide, a ketoreductase, a nitrilase, and/or a nitrile hydratase. Systems, compositions, and methods, in some embodiments, may produce a ?-hydroxy carboxylic acid and/or a ?-hydroxy carboxylic amide in enantiomeric excess under convenient conditions (e.g., pH 5-9 and temperatures under 50° C.).
    Type: Application
    Filed: March 21, 2007
    Publication date: October 21, 2010
    Inventors: Ling Hua, Dunming Zhu, Chandrani Mukherjee, Edward R. Biehl
  • IDENTIFICATION OF A NITRILASE FROM B. JAPONICUM BY RATIONAL GENOME MINING AND METHODS OF USE
    Publication number: 20100137636
    Abstract: The present disclosure relates to methods of rational genome mining. A method may include narrowing the number of clones that would otherwise need to be screened and/or identifying a gene with a desired catalytic activity. The disclosure also relates to a nitrile hydrolase from Bradyrhizobium japonicum USDA110 first identified by rational genome mining. In addition, the disclosure relates to nitrilase bll6402 and catalytically active variants capable of converting an ?-hydroxy nitriles, a ?-hydroxy nitrile and/or an ?,?-dinitrile to a carboxylic acid.
    Type: Application
    Filed: June 9, 2009
    Publication date: June 3, 2010
    Inventors: Dunming Zhu, Ling Hua, Edward R. Biehl, Chandrani Mukherjee
  • Method for degrading chemical warfare agents using Mn(VII) oxide with-and-without solid support
    Publication number: 20100010283
    Abstract: The invention provides a novel method of detoxifying highly toxic chemicals, and treating surfaces contaminated, or potentially contaminated, with toxic chemical agents such as chemical warfare agents and/or industrial toxins. The methods utilizes a novel sorbent compound which comprises Mn(VII) mineral which can be either solid supported or non-solid supported. The Mn(VII) mineral can be provided in a number of different forms including creams, lotions, powders, liquids, slurries and aerosols.
    Type: Application
    Filed: May 9, 2005
    Publication date: January 14, 2010
    Inventors: R. K. Vempati, Edward R. Biehl, Ramesh S. Hegde