Patents by Inventor Edward Rowan
Edward Rowan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11053349Abstract: A polymer hydrogel having a polymer formed by the crosslinking reaction of a polymeric unit A according to formula (I), with a crosslinking unit B according to formula (II) and water, wherein n=100-10,000, preferable 250-2500, more preferable 500-1500; m=independently 2-10, preferably 3 or 4; FG is a functional moiety that can be covalently coupled to the complementary functional moiety F1 or F2 of the crosslinking unit (B); k=0.01-0.05; h=0, 1 or 2; the spacer is an organic moiety, having a main chain comprising at least two functional moieties F1 and F2, wherein the length of the crosslinker in the extended conformation as determined by molecular modeling (including spacer and functional groups F1 and F2) is between 2.5 and 12 nm, or wherein the length is between 20 and 80 atoms.Type: GrantFiled: December 5, 2017Date of Patent: July 6, 2021Assignee: STICHTING KATHOLIEKE UNIVERSITEITInventors: Paul Kouwer, Alan Edward Rowan, Daniël Schoenmakers
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Publication number: 20200140604Abstract: A polymer hydrogel having a polymer formed by the crosslinking reaction of a polymeric unit A according to formula (I), with a crosslinking unit B according to formula (II) and water, wherein n=100-10,000, preferable 250-2500, more preferable 500-1500; m=independently 2-10, preferably 3 or 4; FG is a functional moiety that can be covalently coupled to the complementary functional moiety F1 or F2 of the crosslinking unit (B); k=0.01-0.05; h=0, 1 or 2; the spacer is an organic moiety, having a main chain comprising at least two functional moieties F1 and F2, wherein the length of the crosslinker in the extended conformation as determined by molecular modeling (including spacer and functional groups F1 and F2) is between 2.5 and 12 nm, or wherein the length is between 20 and 80 atoms.Type: ApplicationFiled: December 5, 2017Publication date: May 7, 2020Inventors: Paul KOUWER, Alan Edward ROWAN, Daniël SCHOENMAKERS
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Patent number: 10350298Abstract: The present invention relates to protein constructs that comprise one or more peptides, proteins, factors, compounds or other components as further described herein that are linked to and/or are linked to each other via a helical polymeric backbone. The constructs of the invention are suitable for administration to a human or animal body and can be used for pharmaceutical purposes, for example, for immunotherapy, such as for treating cancer and for other immunological applications, as well as for other therapeutic, prophylactic and/or diagnostic purposes.Type: GrantFiled: July 7, 2011Date of Patent: July 16, 2019Assignees: Stichting Katholieke Universiteit, Radboud University Nijmegen Medical Centre, Stichting Katholieke Universiteit, meer in het bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Carl Gustav Figdor
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Patent number: 10266809Abstract: A process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process includes the steps of: i) copolymerizing a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is 1:500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornmadiene-based-azide couplings, vinylsulphone-thiol couplingType: GrantFiled: July 16, 2014Date of Patent: April 23, 2019Assignee: STICHTING KATHOLIEKE UNIVERSITEITInventors: Alan Edward Rowan, Zaskia Hillet Eksteen Akeroyd, Christopher Wilson, Petrus Johannes Geutjes, Wouter F. J. Feitz, Egbert Oosterwijk
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Patent number: 10125222Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: GrantFiled: December 8, 2016Date of Patent: November 13, 2018Assignee: STICHTING KATHOLIEKE UNIVERSITEIT MEER IN HET BIJZONDER RADBOUD UNIVERSITEIT NIJMEGENInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Publication number: 20180245049Abstract: A cell culture including a cell culturing medium for growing stem cells, a three-dimensional (3D) cell growth matrix and stem cells, wherein the cell culture has a critical stress ?c of 2-30 Pa, wherein the critical stress is a stress which marks an onset of strain stiffening and wherein the cell culture has a storage modulus G? measured at 37° C. of 50-1000 Pa.Type: ApplicationFiled: September 5, 2016Publication date: August 30, 2018Inventors: Wouter Franciscus Joannes FEITZ, Egbert OOSTERWIJK, Silvia Maria MIHAILA, Alan Edward ROWAN
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Publication number: 20170088670Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: ApplicationFiled: December 8, 2016Publication date: March 30, 2017Applicant: Stichting Katholieke Universiteit Meer in Het BijzonderInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Patent number: 9408573Abstract: A patient interface for a reusable optical sensor, the patient interface including a compliant element defining a pocket having a lower wall defining an opening therethrough, the pocket being configured to removably receive the reusable optical sensor. The compliant element includes a first wing and a second wing configured for conformal placement on a patient's body. A condition of a patient may be monitored by inserting an optical sensor into a patient interface, applying the patient interface to the patient, obtaining a measurement with the optical sensor related to the condition of the patient, removing the patient interface from the patient, and removing the sensor from the patient interface.Type: GrantFiled: August 9, 2012Date of Patent: August 9, 2016Assignee: Sotera Wireless, Inc.Inventors: Randall Welch, Gwenn Ellerby, Peter Scott, Babs Soller, Edward Rowan
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Publication number: 20160137977Abstract: A process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process includes the steps of: i) copolymerizing a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is 1:500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornmadiene-based-azide couplings, vinylsulphone-thiol couplingType: ApplicationFiled: July 16, 2014Publication date: May 19, 2016Inventors: Alan Edward ROWAN, Zaskia Hillet EKSTEEN AKEROYD, Christopher WILSON, Petrus Johannes GEUTJES, Wouter F.J. FEITZ, Egbert OOSTERWIJK
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Publication number: 20150297137Abstract: A patient interface for a reusable optical sensor, the patient interface including a compliant element defining a pocket having a lower wall defining an opening therethrough, the pocket being configured to removably receive the reusable optical sensor. The compliant element includes a first wing and a second wing configured for conformal placement on a patient's body. A condition of a patient may be monitored by inserting an optical sensor into a patient interface, applying the patient interface to the patient, obtaining a measurement with the optical sensor related to the condition of the patient, removing the patient interface from the patient, and removing the sensor from the patient interface.Type: ApplicationFiled: August 9, 2012Publication date: October 22, 2015Applicant: Reflectance Medical, Inc.Inventors: Randall Welch, Gwenn Ellerby, Peter Scott, Babs Soller, Edward Rowan
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Publication number: 20150105516Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol)-functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol-functionalized isocyanopeptides. Several isocyanopeptides may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably, the isocyanopeptides are functionalized with at least three ethylene glycol side chains. The peptides may comprise L-amino acids, D-amino acids or D, L-amino acids. The obtained oligoalkylene-functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: ApplicationFiled: December 19, 2014Publication date: April 16, 2015Inventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Patent number: 8981001Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol) functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol functionalized isocyanopeptides. Several isocyanopeptide may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably the isocyanopeptides are functionalized with at least 3 ethylene glycol side chains. The peptides may comprise L aminoacids, D-aminoacids or D, L-aminoacids. The obtained oligoalkylene functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: GrantFiled: July 16, 2010Date of Patent: March 17, 2015Assignee: Stichting Katholieke Universiteit Meer in Het Bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf
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Publication number: 20130268247Abstract: A method of modeling pressure characteristics of a reservoir includes obtaining cumulative fluid production data for a plurality of wells in the reservoir for a selected time, obtaining reservoir pressure depletion values for an independent set of wells at the selected time, determining a well spacing value for each of the plurality of production wells, using the cumulative fluid production data and the well spacing values, calculating a cumulative fluid production per unit area value for each of the plurality of wells, calculating a relationship between the reservoir pressure depletion values and the cumulative fluid production per unit area values, using the calculated relationship, generating residual depletion pressure data, and using the calculated relationship and the residual depletion pressure data to transform cumulative fluid production data into predicted pressure values for reservoir flow units.Type: ApplicationFiled: April 5, 2012Publication date: October 10, 2013Applicant: Chevron U.S.A. Inc.Inventors: Dana Edward Rowan, Shamsul Aziz
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Publication number: 20130202548Abstract: The present invention relates to protein constructs that comprise one or more peptides, proteins, factors, compounds or other components as further described herein that are linked to and/or are linked to each other via a helical polymeric backbone. The constructs of the invention are suitable for administration to a human or animal body and can be used for pharmaceutical purposes, for example, for immunotherapy, such as for treating cancer and for other immunological applications, as well as for other therapeutic, prophylactic and/or diagnostic purposes.Type: ApplicationFiled: July 7, 2011Publication date: August 8, 2013Applicant: Stichting Katholieke Universiteit of NijmegenInventors: Alan Edward Rowan, Carl Gustav Figdor
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Publication number: 20120149836Abstract: The present invention relates to a process for the preparation of oligo(alkylene glycol) functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol functionalized isocyanopeptides. Several isocyanopeptide may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably the isocyanopeptides are functionalized with at least 3 ethylene glycol side chains. The peptides may comprise L aminoacids, D-aminoacids or D, L-aminoacids. The obtained oligoalkylene functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.Type: ApplicationFiled: July 16, 2010Publication date: June 14, 2012Applicant: Stichting Katholieke Universiteit Meer in Het Bijzonder Radboud Universiteit NijmegenInventors: Alan Edward Rowan, Roeland Johannes Maria Nolte, Jeroen Johannes Lambertus Maria Cornelissen, Heather Joy Kitto, Erik Schwartz, Matthieu Koepf