Patents by Inventor Edward Sinclair
Edward Sinclair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108645Abstract: The present invention relates to a method of treating or preventing DNA damage in a cell or cellular senescence of a cell or induction of the senescence associated secretory phenotype (SASP) in a cell, or for treating or preventing the effects of aging, or for preventing or treating cellular senescence and/or induction of SASP associated with high caloric intake or obesity, or for reducing the side effects of chemotherapy, radiotherapy, corticoid treatment, anti-retroviral treatment, or PPAR? agonist treatment comprising administering an effective amount of an NAD+ agonist.Type: ApplicationFiled: May 5, 2023Publication date: April 4, 2024Inventors: Lindsay Edward WU, David Andrew SINCLAIR
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Publication number: 20150168277Abstract: Disclosed herein are apparatuses and methods handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. the flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.Type: ApplicationFiled: February 25, 2015Publication date: June 18, 2015Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
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Patent number: 8967024Abstract: Apparatuses and methods for handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. The flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.Type: GrantFiled: July 20, 2011Date of Patent: March 3, 2015Assignee: Vertex Pharmaceuticals, Inc.Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
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Patent number: 8783339Abstract: Apparatuses, systems, and methods in accordance with the present disclosure are disclosed herein. The system includes a gripping tool operatively connected to and suspended from the top drive assembly, in which the gripping tool includes an axis defined therethrough and a gripping member, and an adaptor apparatus having a first end and a second end. The at least one gripping member engages the adaptor apparatus, and the second end includes a connection member to connect with the tubular member.Type: GrantFiled: January 14, 2011Date of Patent: July 22, 2014Assignee: Frank's International, Inc.Inventors: Edward Sinclair, Guy Hustinx, Patrick Neil Sibille
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Publication number: 20140046182Abstract: Embodiments of the present invention describe methods of determining the occlusion of body lumens and apparatuses for doing so. In one particular embodiment, the occlusion of the fallopian tubes by an intrafallopian contraceptive device may be confirmed by contrast enhanced ultrasonography (also known as stimulated acoustic emission hysterosalpingo-contrast sonography). In these embodiments a contrast agent containing microbubbles is used.Type: ApplicationFiled: September 6, 2013Publication date: February 13, 2014Inventors: Viviane Connor, Betsy Swann, Edward Sinclair
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Patent number: 8551001Abstract: Embodiments of the present invention describe methods of determining the occlusion of body lumens and apparatuses for doing so. In one particular embodiment, the occlusion of the fallopian tubes by an intrafallopian contraceptive device may be confirmed by contrast enhanced ultrasonography (also known as stimulated acoustic emission hysterosalpingo-contrast sonography). In these embodiments a contrast agent containing microbubbles is used.Type: GrantFiled: February 16, 2012Date of Patent: October 8, 2013Assignee: Conceptus, Inc.Inventors: Viviane Connor, Edward Sinclair, Betsy Swann
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Publication number: 20130019725Abstract: Disclosed herein are apparatuses and methods handling a portion of a tissue sample when sectioned by a microtome. The apparatuses include a container, a tissue sample holder in the container, and one or more outlets configured to allow flow of a fluid from the container. the flow through the outlet causes a portion of the tissue sample sectioned by a microtome to move into the outlet. The methods include sectioning one or more portions of a tissue sample, and flowing a fluid past the tissue sample to cause the one or more portions of the tissue sample to move away from the tissue sample and toward at least one fluid outlet.Type: ApplicationFiled: July 20, 2011Publication date: January 24, 2013Applicant: Vertex Pharmaceuticals, Inc.Inventors: Sanjay Shivayogi Magavi, Jack Barger, Michael Paul Emery, James Edward Sinclair, Jorge Arturo Ayala
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Publication number: 20120190980Abstract: Embodiments of the present invention describe methods of determining the occlusion of body lumens and apparatuses for doing so. In one particular embodiment, the occlusion of the fallopian tubes by an intrafallopian contraceptive device may be confirmed by contrast enhanced ultrasonography (also known as stimulated acoustic emission hysterosalpingo-contrast sonography). In these embodiments a contrast agent containing microbubbles is used.Type: ApplicationFiled: February 16, 2012Publication date: July 26, 2012Inventors: Viviane Connor, Edward Sinclair, Betsy Swann
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Patent number: 8123693Abstract: Embodiments of the present invention describe methods of determining the occlusion of body lumens and apparatuses for doing so. In one particular embodiment, the occlusion of the fallopian tubes by an intrafallopian contraceptive device may be confirmed by contrast enhanced ultrasonography (also known as stimulated acoustic emission hysterosalpingo-contrast sonography). In these embodiments a contrast agent containing microbubbles is used.Type: GrantFiled: June 20, 2006Date of Patent: February 28, 2012Assignee: Conceptus, Inc.Inventors: Viviane Connor, Edward Sinclair, Betsy Swann
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Publication number: 20110174542Abstract: Apparatuses, systems, and methods in accordance with the present disclosure are disclosed herein. The system includes a gripping tool operatively connected to and suspended from the top drive assembly, in which the gripping tool includes an axis defined therethrough and a gripping member, and an adaptor apparatus having a first end and a second end. The at least one gripping member engages the adaptor apparatus, and the second end includes a connection member to connect with the tubular member.Type: ApplicationFiled: January 14, 2011Publication date: July 21, 2011Applicant: FRANK'S INTERNATIONAL, INC.Inventors: Edward Sinclair, Guy Hustinx, Patrick Neil Sibille
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Publication number: 20110137150Abstract: Embodiments of the present invention describe methods of determining the occlusion of body lumens and apparatuses for doing so. In one particular embodiment, the occlusion of the fallopian tubes by an intrafallopian contraceptive device may be confirmed by contrast enhanced ultrasonography (also known as stimulated acoustic emission hysterosalpingo-contrast sonography). In these embodiments a contrast agent containing microbubbles is used.Type: ApplicationFiled: June 20, 2006Publication date: June 9, 2011Inventors: Viviane Connor, Edward Sinclair, Betsy Swann
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Patent number: 7337853Abstract: Method and apparatus for installing control lines and pipe into a well. The pipe-holding spider that is normally mounted on the rig floor is supportably retained in a vertically movable retainer. The retainer is adapted for controllably elevating the spider above the rig floor when the pipe slips within the spider are not engaged with the outer surface of the pipe string, thereby providing personnel access to a portion of the length of the pipe string below the elevated spider and above the rig floor. Personnel are provided with access to the pipe string for applying a fastener to secure the control line to the pipe string. The control line is supplied from above the spider and is positioned by a control line guide supported on the spider or retainer to pass through the spider outside the path of pipe gripping members within the spider.Type: GrantFiled: January 10, 2006Date of Patent: March 4, 2008Assignee: Frank's International, Inc.Inventors: Jean Buytaert, Luciano Spadoni, Edward Sinclair, Brian David Begnaud, Charles Michael Webre
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Publication number: 20060108122Abstract: Method and apparatus for installing control lines and pipe into a well. The pipe-holding spider that is normally mounted on the rig floor is supportably retained in a vertically movable retainer. The retainer is adapted for controllably elevating the spider above the rig floor when the pipe slips within the spider are not engaged with the outer surface of the pipe string, thereby providing personnel access to a portion of the length of the pipe string below the elevated spider and above the rig floor. Personnel are provided with access to the pipe string for applying a fastener to secure the control line to the pipe string. The control line is supplied from above the spider and is positioned by a control line guide supported on the spider or retainer to pass through the spider outside the path of pipe gripping members within the spider.Type: ApplicationFiled: January 10, 2006Publication date: May 25, 2006Inventors: Jean Buytaert, Luciano Spadoni, Edward Sinclair, Brian Begnaud, Charles Webre
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Publication number: 20050183862Abstract: A method and apparatus are provided for installing control lines and pipe into a well. The pipe-holding spider that is normally mounted on the rig floor is supportably retained in a vertically movable retainer. The retainer is adapted for controllably elevating the spider above the rig floor when the pipe slips within the spider are not engaged with the outer surface of the pipe string, thereby providing personnel access to a portion of the length of the pipe string below the elevated spider and above the rig floor. Personnel are provided with access to the pipe string for applying a fastener to secure the control line to the pipe string.Type: ApplicationFiled: April 26, 2005Publication date: August 25, 2005Inventors: Jean Buytaert, Luciano Spadoni, Edward Sinclair
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Patent number: 6889772Abstract: A method and apparatus are provided for installing control lines and pipe into a well. The pipe-holding spider that is normally mounted on the rig floor is supportably retained in a vertically movable retainer. The retainer is adapted for controllably elevating the spider above the rig floor when the pipe slips within the spider are not engaged with the outer surface of the pipe string, thereby providing personnel access to a portion of the length of the pipe string below the elevated spider and above the rig floor. Personnel are provided with access to the pipe string for applying a fastener to secure the control line to the pipe string.Type: GrantFiled: October 23, 2002Date of Patent: May 10, 2005Assignee: Frank's International, Inc.Inventors: Jean Buytaert, Luciano Spadoni, Edward Sinclair
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Publication number: 20040079533Abstract: A method and apparatus are provided for installing control lines and pipe into a well. The pipe-holding spider that is normally mounted on the rig floor is supportably retained in a vertically movable retainer. The retainer is adapted for controllably elevating the spider above the rig floor when the pipe slips within the spider are not engaged with the outer surface of the pipe string, thereby providing personnel access to a portion of the length of the pipe string below the elevated spider and above the rig floor. Personnel are provided with access to the pipe string for applying a fastener to secure the control line to the pipe string.Type: ApplicationFiled: October 23, 2002Publication date: April 29, 2004Inventors: Jean Buytaert, Luciano Spadoni, Edward Sinclair
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Patent number: 6177946Abstract: A method and apparatus for processing video and graphics data is accomplished by receiving display data that includes at least one of video data and graphics data. If the display data includes video data, the video data is converted into graphics formatted video data when a first control signal is in a first state. The graphics formatted video data, which is now in a format consistent with the computer monitor (e.g., an RGB video format), is then provided to the computer monitor based on the enablement of the first control signal. Alternately, or in addition to, the graphics data may be provided to the computer monitor. If the display data includes graphics data, i.e., computer generated data for display on a computer monitor, the graphics data is converted into video formatted graphics data when a second control signal is in a second state. In this conversion, the graphics data, which is in a RGB format, is converted into a video format, e.g., a YUV data format.Type: GrantFiled: November 14, 1997Date of Patent: January 23, 2001Assignee: ATI Technologies, Inc.Inventors: David Edward Sinclair, Oswin Hall
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Patent number: 4186230Abstract: A moldable tufted carpet automobile mat, the molded mat and the process of preparing the mat, the moldable automobile mat comprising in combination: a nonwoven fabric or a tufted carpet having a tufted face surface and a back surface; a latex precoat; a thin layer of a stiff, heat-moldable thermoplastic foam of a blend of an elastomer and a resin having a thickness of up to about one-eighth to about three-eighths of an inch.Type: GrantFiled: October 2, 1978Date of Patent: January 29, 1980Assignee: The Goodyear Tire & Rubber CompanyInventors: Edward A. Sinclair, John M. Kalbfleisch
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Patent number: 4020026Abstract: This invention provides a method of treating rubber in the latex or nonlatex form with polyethylenimine to improve the plasticity and plasticity retention index of the unvulcanized elastomer.Type: GrantFiled: April 17, 1975Date of Patent: April 26, 1977Assignee: The Goodyear Tire & Rubber CompanyInventors: Frits W. Janssen, Edward A. Sinclair