Patents by Inventor Edward Stafford
Edward Stafford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240108709Abstract: The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.Type: ApplicationFiled: March 20, 2023Publication date: April 4, 2024Applicant: President and Fellows of Harvard CollegeInventors: Michael Super, Edward J. Doherty, Mark Joseph Cartwright, Des White, Alexander Stafford, Omar Abdel-Rahman Ali, Amanda Graveline, Donald E. Ingber, David J. Mooney, Benjamin Seiler
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Publication number: 20240101631Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.Type: ApplicationFiled: October 11, 2023Publication date: March 28, 2024Applicant: Merck Sharp & Dohme LLCInventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
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Publication number: 20230331570Abstract: A method of producing a particulate lithium metal oxide or lithium metal phosphate material comprising the steps of providing one or more metal compounds, adding sufficient water to dissolve the one or more metal compounds to form a metal compound solution, adding a first basic solution, a second basic solution and the metal compound solution at predetermined rates to a reaction vessel containing water to form a reaction mixture, heating the reaction mixture while maintaining a pH of the reaction mixture in a predetermined pH range, adding a lithium compound, adding a fatty acid, filtering a precipitate, washing and preferably drying the precipitate, calcining the dried precipitate in an atmosphere containing oxygen to form a calcined lithium metal oxide or lithium metal phosphate, cooling and sizing the calcined lithium metal oxide or lithium metal phosphate to produce a particulate lithium metal oxide or lithium metal phosphate material having a predetermined average particle size.Type: ApplicationFiled: April 13, 2023Publication date: October 19, 2023Applicant: SylvatexInventors: Yi-Ting Chen, Yanying Lu, Valeria Miramontes, Edward Stafford, Daniel Teav Sun, Ahmad Dehestani, Melvin Louis Luetkens, JR.
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Patent number: 10845980Abstract: A technique is described herein for facilitating movement of graphical objects across display screens. In one manner of operation, the method includes: displaying a representation of a first movement as a user moves a graphical object across a source screen; detecting that the user has moved the graphical object into a graphical source portal associated with the source screen; associating the graphical object with two or more graphical destination portals provided by the plural display screens, in addition to the graphical source portal, such that the graphical object is accessible from the graphical source portal and any graphical destination portal; detecting that the user has removed the graphical object from a chosen graphical portal in a chosen screen; displaying the graphical object as having been removed from all graphical portals; and displaying a second movement as the user moves the graphical object across the chosen screen to a final destination.Type: GrantFiled: March 28, 2018Date of Patent: November 24, 2020Assignee: Micosoft Technology Licensing, LLCInventors: Patrick Joseph Derks, Peter Eugene Hammerquist, Eric J. Hull, Sophors Khut, Cassandra April King, Christian Klein, Bryan Mamaril, Nishad Mulye, Kenton Allen Shipley, Daniel Edward Stafford
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Publication number: 20190302980Abstract: A technique is described herein for facilitating movement of graphical objects across display screens. In one manner of operation, the method includes: displaying a representation of a first movement as a user moves a graphical object across a source screen; detecting that the user has moved the graphical object into a graphical source portal associated with the source screen; associating the graphical object with two or more graphical destination portals provided by the plural display screens, in addition to the graphical source portal, such that the graphical object is accessible from the graphical source portal and any graphical destination portal; detecting that the user has removed the graphical object from a chosen graphical portal in a chosen screen; displaying the graphical object as having been removed from all graphical portals; and displaying a second movement as the user moves the graphical object across the chosen screen to a final destination.Type: ApplicationFiled: March 28, 2018Publication date: October 3, 2019Inventors: Patrick Joseph DERKS, Peter Eugene HAMMERQUIST, Eric J. HULL, Sophors KHUT, Cassandra April KING, Christian KLEIN, Bryan MAMARIL, Nishad MULYE, Kenton Allen SHIPLEY, Daniel Edward STAFFORD
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Publication number: 20140250319Abstract: An apparatus for providing a computing environment in a computing system includes a first node, a second node, an operations server, and a communication link. The first node is capable of supporting a production computing environment and 5 has a first disk storage. The second node is capable of supporting a second operational computing environment, independent of the production computing environment and has a second disk storage. A method of switching a production computing environment from a first node, having a first disk storage, to a second node in the event of a failure on the first 15 node includes determining if the first node had a failure and if the first node had a failure: reassigning ownership of the partition definition to the second node; restoring communications configuration on the second node; and booting the second node from the first disk storage.Type: ApplicationFiled: March 1, 2013Publication date: September 4, 2014Inventors: Michael John Rieschl, Edward Stafford, Thomas J. Bechtold, James R. McBreen
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Patent number: 8495413Abstract: An apparatus for providing a computing environment in a computing system includes a first node, a second node, an operations server, and a communication link. The first node is capable of supporting a production computing environment and has a first disk storage. The second node is capable of supporting a second operational computing environment, independent of the production computing environment and has a second disk storage. The operations server manages the first and second node and can switch the production computing environment from the first node to the second node. The communications link allows communication between the first node, the second node, and the operations server. The second node can take over the production computing environment from the first node upon a failure of the first node by providing the second node with access to the first disk storage and rebooting the second node from the first disk storage.Type: GrantFiled: December 15, 2009Date of Patent: July 23, 2013Assignee: Unisys CorporationInventors: Michael John Rieschl, Edward Stafford, Thomas J. Bechtold, James R. McBreen
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Publication number: 20110141882Abstract: An apparatus for providing a computing environment in a computing system includes a first node, a second node, an operations server, and a communication link. The first node is capable of supporting a production computing environment and has a first disk storage. The second node is capable of supporting a second operational computing environment, independent of the production computing environment and has a second disk storage. The operations server manages the first and second node and can switch the production computing environment from the first node to the second node. The communications link allows communication between the first node, the second node, and the operations server. The second node can take over the production computing environment from the first node upon a failure of the first node by providing the second node with access to the first disk storage and rebooting the second node from the first disk storage.Type: ApplicationFiled: December 15, 2009Publication date: June 16, 2011Inventors: Michael John Rieschl, Edward Stafford, Thomas J. Bechtold, James R. McBreen
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Patent number: 7530297Abstract: A miter saw has a remotely actuated bevel angle locking system and a bevel angle adjustment assistance system with a remote override actuator so that the user does not need to reach around to the back of the miter saw to adjust the bevel angle. The remote actuator for the bevel angle locking system can be provided on the front of the miter saw's turntable to form a suite of actuators with the miter lock and miter detent override lever. The remote override actuator for the bevel angle adjustment assistance system can be provided on the handle in proximity to the power switch. Also disclosed is a bevel angle adjustment assistance system in which each of the preset bevel angles can be fine tuned simultaneously and which exhibits other advantages.Type: GrantFiled: October 2, 2006Date of Patent: May 12, 2009Assignee: Black & Decker Inc.Inventors: Craig Allen Carroll, Brent Edward Stafford
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Patent number: 7127977Abstract: A miter saw has a remotely actuated bevel angle locking system and a bevel angle adjustment assistance system with a remote override actuator so that the user does not need to reach around to the back of the miter saw to adjust the bevel angle. The remote actuator for the bevel angle locking system can be provided on the front of the miter saw's turntable to form a suite of actuators with the miter lock and miter detent override lever. The remote override actuator for the bevel angle adjustment assistance system can be provided on the handle in proximity to the power switch. Also disclosed is a bevel angle adjustment assistance system in which each of the preset bevel angles can be fine tuned simultaneously and which exhibits other advantages.Type: GrantFiled: August 5, 2002Date of Patent: October 31, 2006Assignee: Porter-Cable/DeltaInventors: Craig Allen Carroll, Brent Edward Stafford
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Publication number: 20060143076Abstract: A method of distributing advertisements, including the steps of placing ads on garment hangers, arranging the hangers ads in a collated sequence, and delivering the collated hanger ads for retail distribution.Type: ApplicationFiled: December 23, 2004Publication date: June 29, 2006Inventor: Edward Stafford
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Patent number: 7036414Abstract: An improved table having improvements related to stock support, such as a rip fence stock support, as well as a lateral-table support system; features of laterally-slideable front and back rip fence guide rails, including an improved front rail configuration, an improved rear rail configuration, and an especially-configured front and back rail combination, including a rail configuration having cross-sectional aspects configured for use as both the front and rear rail, each instance of improved rail configuration providing the basis for an improved rip-fence locking system; improved sliding-rail lock shoes, including lock shoes that comprise an improved cross section for sliding in T-track, as well as lock and support shoes having a particular raised rib, also for improved sliding in a laterally-adjustable rail system, and a system wherein of one two rail shoes per rail, a rail-locking support shoe, is configured for biasing, and wherein the other shoe for each rail, a rail supporting shoe, remains fixed; fronType: GrantFiled: May 17, 2004Date of Patent: May 2, 2006Assignee: Black & Decker Inc.Inventors: Rockne Wade Behne, Todd Chipner, Jaime Garcia, John Charles Smith, Brent Edward Stafford, Zhilong Zhang
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Patent number: 6736042Abstract: An improved table having improvements related to stock support, such as a rip fence stock support, as well as a lateral-table support system; features of laterally-slideable front and back rip fence guide rails, including an improved front rail configuration, an improved rear rail configuration, and an especially-configured front and back rail combination, including a rail configuration having cross-sectional aspects configured for use as both the front and rear rail, each instance of improved rail configuration providing the basis for an improved rip-fence locking system; improved sliding-rail lock shoes, including lock shoes that comprise an improved cross section for sliding in T-track, as well as lock and support shoes having a particular raised rib, also for improved sliding in a laterally-adjustable rail system, and a system wherein of one two rail shoes per rail, a rail-locking support shoe, is configured for biasing, and wherein the other shoe for each rail, a rail supporting shoe, remains fixed; fronType: GrantFiled: March 11, 2002Date of Patent: May 18, 2004Assignee: Porter-Cable CorporationInventors: Rockne Wade Behne, Todd Chipner, Jaime Garcia, John Charles Smith, Brent Edward Stafford, Zhilong Zhang
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Publication number: 20030150311Abstract: A miter saw has a remotely actuated bevel angle locking system and a bevel angle adjustment assistance system with a remote override actuator so that the user does not need to reach around to the back of the miter saw to adjust the bevel angle. The remote actuator for the bevel angle locking system can be provided on the front of the miter saw's turntable to form a suite of actuators with the miter lock and miter detent override lever. The remote override actuator for the bevel angle adjustment assistance system can be provided on the handle in proximity to the power switch. Also disclosed is a bevel angle adjustment assistance system in which each of the preset bevel angles can be fine tuned simultaneously and which exhibits other advantages.Type: ApplicationFiled: August 5, 2002Publication date: August 14, 2003Inventors: Craig Allen Carroll, Brent Edward Stafford
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Patent number: 6569002Abstract: A hand-held oscillating spindle sander is disclosed. The sander includes a pair of toothed pulleys associated with the output shaft. The first pulley is attached to the output shaft for rotation with the output shaft. The second pulley is rotatably disposed on the output shaft for relative rotation with respect to the output shaft. The second pulley includes opposed camming surfaces formed on the inside thereof. A cam follower is attached to and extends from the output shaft so that it is positioned between the opposed camming surfaces. A pair of belts are respectively entrained around the first and second pulleys from a jackshaft rotatably received in the housing. Upon rotation of the belts, both pulleys rotate, but at slightly different speeds. This slight difference in speeds causes the cam follower to move along the opposed camming surfaces to create an oscillation effect for the output shaft.Type: GrantFiled: December 8, 2000Date of Patent: May 27, 2003Assignee: Porter-Cable/DeltaInventors: John Charles Smith, Mark Alan Etter, Brent Edward Stafford, James Timothy Stolzer, Craig Allen Carroll, Thomas O'Neal Walls
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Publication number: 20020174755Abstract: An improved table having improvements related to stock support, such as a rip fence stock support, as well as a lateral-table support system; features of laterally-slideable front and back rip fence guide rails, including an improved front rail configuration, an improved rear rail configuration, and an especially-configured front and back rail combination, including a rail configuration having cross-sectional aspects configured for use as both the front and rear rail, each instance of improved rail configuration providing the basis for an improved rip-fence locking system; improved sliding-rail lock shoes, including lock shoes that comprise an improved cross section for sliding in T-track, as well as lock and support shoes having a particular raised rib, also for improved sliding in a laterally-adjustable rail system, and a system wherein of one two rail shoes per rail, a rail-locking support shoe, is configured for biasing, and wherein the other shoe for each rail, a rail supporting shoe, remains fixed; fronType: ApplicationFiled: March 11, 2002Publication date: November 28, 2002Inventors: Rocken Wade Behne, Todd Chipner, Jaime Garcia, John Charles Smith, Brent Edward Stafford, Zhilong Zhang
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Patent number: 6411954Abstract: A method and apparatus for persisting object oriented data are provided in various embodiments. Persistent storage is established for a working data set and a committed data set. The areas for the working and committed data sets are used for storage of the persistent data objects. After a persistent data object is updated in computer memory, the updated version is written to the working data set. Then, references to the working data set and the committed data set are switched, whereby the working data set becomes the committed data set and the committed data set becomes the working data set.Type: GrantFiled: November 19, 1999Date of Patent: June 25, 2002Assignee: Unisys CorporationInventors: James Roffe, Edward Stafford
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Publication number: 20020009951Abstract: A hand-held oscillating spindle sander is disclosed. The sander includes a pair of toothed pulleys associated with the output shaft. The first pulley is attached to the output shaft for rotation with the output shaft. The second pulley is rotatably disposed on the output shaft for relative rotation with respect to the output shaft. The first and second pulleys have a different number of teeth. The second pulley includes opposed camming surfaces formed on the inside thereof. A cam follower is attached to and extends from the output shaft so that it is positioned between the opposed camming surfaces. A pair of toothed belts are respectively entrained around the first and second pulleys from a jackshaft rotatably received in the housing. Upon rotation of the toothed belts, both pulleys rotate, but at slightly different speeds. This slight difference in speeds causes the cam follower to move along the opposed camming surfaces to create an oscillation effect for the output shaft.Type: ApplicationFiled: December 8, 2000Publication date: January 24, 2002Inventors: John Charles Smith, Mark Alan Etter, Brent Edward Stafford, James Timothy Stolzer, Craig Allen Carroll, Thomas O?apos;Neal Walls
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Patent number: D452804Type: GrantFiled: December 19, 2000Date of Patent: January 8, 2002Assignee: Porter-Cable/DeltaInventors: Mark Alan Etter, John Charles Smith, Brent Edward Stafford, Leslie Daily Gist
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Patent number: D453669Type: GrantFiled: December 19, 2000Date of Patent: February 19, 2002Assignee: Porter-Cable/DeltaInventors: Mark Alan Etter, John Charles Smith, Brent Edward Stafford, Leslie Daily Gist