Abstract: An injector is disclosed for injecting an injectable substance into at least one of the epidermal tissue and the dermal tissue of a subject. The injector includes an outer housing and a control member disposed within the outer housing. A needle head, which is configured to support a plurality of needles, is operatively coupled to the control member. First means are provided in communication with the control member and are configured to be driven by the control member for converting a movement of the control member into a movement of the needle head along an injection direction and toward an injecting position of the needle head. Second means are configured to move the needle head in a direction having a component that is normal to the injection direction and absent movement of the outer housing relative to the skin of the subject.

Abstract: The present invention provides a method of prophylaxis or treatment of a senescence-associated disease or disorder by administering to a subject in need thereof, a therapeutically effective amount of a NMT inhibitor.

Abstract: The present disclosure concerns embodiments of a folding knife having a locking mechanism for locking a blade in open and/or closed positions. The locking mechanism a first locking element on the blade and a corresponding second locking element on the handle that is adapted to engage the first locking element when the blade is in open and/or closed positions. The blade can be mounted on a leaf spring in the handle for pivotal movement relative to the handle between the open and closed positions. The leaf spring functions to support the blade and provide a biasing force that resiliently biases in a direction laterally toward the second locking element on the handle.

Abstract: In certain embodiments of the present disclosure, a folding knife has a biasing mechanism, such as a spring, that applies an opening force to the blade when the blade is in the closed, or folded, position (i.e., the force of the spring creates a moment in the opening direction of the blade). The folding knife includes a latching mechanism that holds the blade in a closed and latched position against the opening force of the spring. To open the blade, manual pressure is applied to the upper edge of the blade (the edge opposite the sharpened edge) to move the blade slightly to a closed and unlatched position to release the blade from being held from the latching mechanism whereupon the blade is then free to pivot under the opening force of the spring.

Abstract: In one embodiment, a folding knife comprises a handle portion and first and second nesting blades pivotally coupled to the handle portion for pivoting movement between respective open and closed positions. The second blade in one embodiment is formed with a recess or notch which is sized and shaped to receive the first blade, allowing both blades to pivot within a common plane. The knife can also include a locking mechanism that is operable to retain the blades against pivoting movement when the blades are in their respective open positions. In particular configurations, the locking mechanism comprises a resilient locking arm configured to lock both blades in their open positions or first blade alone in its respective locking position. In certain embodiments, a folding tool comprises plural nesting tool elements other than knife blades.

Abstract: The present disclosure concerns embodiments of a folding knife having a locking mechanism for locking a blade in open and/or closed positions. The locking mechanism a first locking element on the blade and a corresponding second locking element on the handle that is adapted to engage the first locking element when the blade is in open and/or closed positions. The blade can be mounted on a leaf spring in the handle for pivotal movement relative to the handle between the open and closed positions. The leaf spring functions to support the blade and provide a biasing force that resiliently biases in a direction laterally toward the second locking element on the handle.

Abstract: In certain embodiments of the present disclosure, a folding knife has a biasing mechanism, such as a spring, that applies an opening force to the blade when the blade is in the closed, or folded, position (i.e., the force of the spring creates a moment in the opening direction of the blade). The folding knife includes a latching mechanism that holds the blade in a closed and latched position against the opening force of the spring. To open the blade, manual pressure is applied to the upper edge of the blade (the edge opposite the sharpened edge) to move the blade slightly to a closed and unlatched position to release the blade from being held from the latching mechanism whereupon the blade is then free to pivot under the opening force of the spring.

Abstract: A folding knife includes a handle portion and a blade pivotally coupled to the handle portion for pivoting movement between an open position and a closed position. The knife can include a locking mechanism that retains the blade against pivoting movement when it is in the open position. In particular embodiments, the blade is coupled to the handle portion such that the application of pressure to the blade in a predetermined direction causes displacement of blade relative to the handle portion in the plane within which the blade pivots. The displacement of the blade relative to the handle portion is effective to release the blade from the locking mechanism and allow the blade to be pivoted to the closed position.

Abstract: A method for determining a voltage based or current based state of charge (SOC) and state of health (SOH) of a battery system is provided. The method includes: providing a model of the battery system including an equivalent circuit having both low frequency and high frequency elements; establishing a plurality of functional relationships comprising relationship of the equivalent circuit with SOC; reducing at least part of the plurality of functional relationships into a set of time segmented recursive functional relationships, wherein a state at a first time t can be modeled by a functional presentation of a state at a second time t??t that occurred before the first time t; and computing a set of data points based upon the set of time segmented recursive functional relationships using a matrix for operation in matrix algebra.

Abstract: The present invention relates to a method of determining the probability that a statistical model describes the driving style or usage of a vehicle observed. By identifying an appropriate statistical model, the driving style can be detected and vehicle operation can be optimized. The method may be applied to both hybrid and non-hybrid vehicles. The method may also be augmented to determine the most probable statistical model of the usage of the vehicle. This allows detection of driving styles that can be classified as urban, highway, aggressive, etc. For example, the augmented method can be used to distinguish between highway and urban driving with a very high certainty.

Abstract: A method of modeling a cycle of a vehicle parameter includes generating a plurality of training sets and partially classifying elements of each training set based on a present value of the vehicle parameter and a subsequent change in the vehicle parameter. The method further includes reducing the plurality of training sets to a corresponding plurality of parameter sets based on the elements and defining a plurality of statistical groups of the parameter sets based on a value and a history of that value.

Abstract: A method of estimating a state of charge (SOC) and a state of health (SOH) of an electrochemical cell (EC) includes modeling the EC with a linear equation, measuring a terminal current of the EC, measuring a terminal voltage of the EC and measuring a temperature of the EC. The linear equation is processed through a time-varying state and parameter estimator based on the terminal current, the terminal voltage and the temperature to determine states and parameters of the EC.

Abstract: A state of charge estimator for a battery includes a meter that generates a terminal voltage signal of the battery and a terminal current signal of the battery. A controller employs a linearized model of the battery and a time-varying state estimator. The controller process a synthesized input based on the terminal current and the terminal voltage to estimate the battery state of charge.

Abstract: The current invention addresses these issues in a simple yet effective way. The engagement between the blade and handle is extremely strong when locked, yet can be easily moved with the tip of a finger when the actuating means is engaged. Thus the blade is held rigidly in both the open and closed positions by the interlock and is easily changed in an ergonomically intuitive flick of one finger. The preferred method is to use a cam or cams to rotate against the frame, pivoting near the center of the blade, perpendicular to the axis of blade rotation. Thus the entire knife is composed of three primary parts: the blade, the frame and the cam. No additional springs are needed to effect the mechanism. Another desired feature is an integrated lanyard clip which is designed into the interface of the cam and blade surfaces. This clip is located in a way that allows the user to “pluck” the knife from a ring or lanyard. A belt clip can also be affixed to the u shaped member.

Abstract: A system and method for producing software code is provided. In particular, a new software design methodology is provided that is based on axiomatic design theory. In one aspect, axiomatic design theory is adapted for use in designing object-oriented software programs. This methodology overcomes the shortcomings of various software design strategies including extensive software development and debugging time and the need for extensive maintenance. Because traditional software design strategies are not heuristic and do not provide basic principles for the development of good software systems, bad design habits produce poor quality software. A design framework using axiomatic design for software overcomes many of the shortcomings of current software design techniques: high maintenance costs, limited reusability, the need for extensive debugging and testing, poor documentation, and limited extensibility of the software, all of which result in high development cost of software.