Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: Systems and methods include registering use of a virtual certification number (VCN) at a secure entity by receiving, at an external gateway, a registration request comprising an external request code and a primary account number (PAN), wherein the external request code is unique to the secure entity, determining that the external request code is an unregistered external request code, receiving a tokenized PAN based on the PAN, receiving an account identifier by applying the tokenized PAN to a certification mechanism tool application programing interface (API), generating a certification mechanism reference identifier by encrypting a certification mechanism associated with the account identifier and the tokenized PAN, updating a database to associate the certification mechanism reference identifier with the external request code, and transmitting, via the external gateway, a registration authentication to an external entity, the registration authentication comprising the external request code.

Abstract: Systems and methods include providing virtual certification number (VCN) authorizations to an external entity by receiving a plurality of secure entity global authorizations comprising global VCN authorizations and global primary account number (PAN) authorizations, identifying the global VCN authorizations, identifying a subset of the global VCN authorizations, each of the subset of the global VCN authorizations corresponding to an external entity authorization, comparing the subset of global VCN authorizations to previously provided VCN authorizations, to identify an unsent VCN authorization, storing a transmittable unsent VCN authorization based on the unsent VCN authorization, providing an unsent authorization indication to the external entity, receiving, from the external entity, a request for the unsent VCN authorization based on providing the unsent authorization indication to the external entity, and providing the transmittable unsent VCN authorization to the external entity, based on storing the tran

Abstract: Systems and methods for authorizing a source for virtual certification number (VCN) use include receiving a VCN use request from an external entity, the VCN use request including the VCN and transaction data associated with the VCN use request, determining that a VCN binding for the VCN is a strict binding, mapping the transaction data to a transaction source having a transaction source identifier based on the VCN binding being the strict binding, determining a VCN source identifier for the source associated with the VCN, based on a registration authentication of the VCN with the source, comparing the VCN source identifier to the transaction source identifier, determining that the VCN source identifier corresponds to the transaction source identifier based on comparing the VCN source identifier to the transaction source identifier, outputting an approved authorization indicating that the VCN is associated with the source and the source is the transaction source.

Abstract: When a loan payment failure occurs, a loan server can retry a payment from a client's financial institution sources rather than immediately charging the client for the payment failure. The payment retry is scheduled on a Friday that is at least three days after the payment failure. If a payment failure from the financial institution sources to the loan server occurs between a Friday and the following Monday the payment retry by the loan server to the financial institution sources will occur on the first following Friday and if the payment failure occurs on Tuesday, Wednesday or Thursday, the payment retry will occur on the second following Friday which is the Friday of the following week from the failure date.

Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

Abstract: A peritoneal dialysis system includes a cycler including a pump actuator, a heater and a heating pan operable with the heater, and a disposable set operable with the cycler. The heating pan includes a sidewall forming a slot. The disposable set includes a pumping cassette and a heater/mixing container. The pumping cassette includes a pump chamber configured to be actuated by the pump actuator. Additionally, the heater/mixing container is in fluid communication with the pumping cassette and is sized to be received at the heating pan. The heater/mixing container includes a port configured such that when the port is slid into the slot of the heater pan sidewall, the port is prevented from rotating about an axis transverse to a direction of flow through the port.

Abstract: This disclosure provides recombinant DNA constructs and transgenic plants having enhanced traits such as increased yield, increased nitrogen use efficiency, and enhanced drought tolerance or water use efficiency. Transgenic plants may include field crops as well as plant propagules and progeny of such transgenic plants. Methods of making and using such transgenic plants are also provided. This disclosure also provides methods of producing seed from such transgenic plants, growing such seed, and selecting progeny plants with enhanced traits. Also disclosed are transgenic plants with altered phenotypes which are useful for screening and selecting transgenic events for the desired enhanced trait.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: Systems and methods include providing virtual certification number (VCN) authorizations to an external entity by receiving a plurality of secure entity global authorizations comprising global VCN authorizations and global primary account number (PAN) authorizations, identifying the global VCN authorizations, identifying a subset of the global VCN authorizations, each of the subset of the global VCN authorizations corresponding to an external entity authorization, comparing the subset of global VCN authorizations to previously provided VCN authorizations, to identify an unsent VCN authorization, storing a transmittable unsent VCN authorization based on the unsent VCN authorization, providing an unsent authorization indication to the external entity, receiving, from the external entity, a request for the unsent VCN authorization based on providing the unsent authorization indication to the external entity, and providing the transmittable unsent VCN authorization to the external entity, based on storing the tran

Abstract: Systems and methods include registering use of a virtual certification number (VCN) at a secure entity by receiving, at an external gateway, a registration request comprising an external request code and a primary account number (PAN), wherein the external request code is unique to the secure entity, determining that the external request code is an unregistered external request code, receiving a tokenized PAN based on the PAN, receiving an account identifier by applying the tokenized PAN to a certification mechanism tool application programing interface (API), generating a certification mechanism reference identifier by encrypting a certification mechanism associated with the account identifier and the tokenized PAN, updating a database to associate the certification mechanism reference identifier with the external request code, and transmitting, via the external gateway, a registration authentication to an external entity, the registration authentication comprising the external request code.

Abstract: Systems and methods for triggering a virtual certification number (VCN) generation for use at a source include receiving a VCN generation request from an external entity, the VCN generation request comprising an external request code, external risk signals, and one or more source data for the source, verifying a registration authentication of an account associated with the external request code by comparing the external request code to a database entry, identifying a certification mechanism reference identifier associated with the external request code based on verifying the registration authentication, generating a risk authentication based on a risk analysis conducted using the external risk signals and the external request code, identifying a source identifier based on the one or more source data, and generating the VCN based on the certification mechanism reference identifier and the source identifier.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: A technique is provided for determining a loss risk assessment score for a vehicle trip. The technique includes, at a vehicle, a computing device receiving first information indicative of operation of the vehicle. The technique also includes, at the vehicle, the computing device receiving second information indicative of an environment at a particular location and time. The computing device correlates the first information and the second information to generate a data set. The technique also includes determining a score for the vehicle trip based at least in part upon the generated data set.

Abstract: A portable device for washing and spin-drying laundry, comprising a cover and a bag body, wherein the cover is provided with a rotating disk, and a user can rotate the rotating disk through a grip provided on the rotating disk, so that the rotating disk is rotated relative to the cover. A storage bag is connected at the bottom of the rotating disk, which can be used to store the laundry to be washed. The bag body is mainly made of soft material and can be folded for storage. An opening is formed for the cover to be assembled. When the present disclosure is used, the laundry to be washed is first placed in the storage bag, then the storage bag can be connected to the cover, and finally the cover can be combined with the bag body. Thereafter, the user holds the grip to turn the rotating disk such that the storage bag rotates inside the bag body to perform the washing and spin-drying operations.

Abstract: A portable device for washing and spin-drying laundry, comprising a cover and a bag body, wherein the cover is provided with a rotating disk, and a user can rotate the rotating disk through a grip provided on the rotating disk, so that the rotating disk is rotated relative to the cover. A storage bag is connected at the bottom of the rotating disk, which can be used to store the laundry to be washed. The bag body is mainly made of soft material and can be folded for storage. An opening is formed for the cover to be assembled. When the present disclosure is used, the laundry to be washed is first placed in the storage bag, then the storage bag can be connected to the cover, and finally the cover can be combined with the bag body. Thereafter, the user holds the grip to turn the rotating disk such that the storage bag rotates inside the bag body to perform the washing and spin-drying operations.

Abstract: An example integrated circuit includes a memory including a non-deterministic finite automata (NFA) buffer configured to store a plurality of instructions defining an ordered sequence of instructions of at least a portion of an NFA graph, the portion of the NFA graph comprising a plurality of nodes arranged along a plurality of paths. The NFA engine determines a current symbol and one or more subsequent symbols of a payload segment that satisfy a match condition specified by a subset of instructions of the plurality of instructions for a path of the plurality of paths and in response to determining the current symbol and the one or more subsequent symbols of the payload segment that satisfy the match condition, outputs an indication that the payload data has resulted in a match.

Abstract: An example processing device includes a memory including a discreet finite automata (DFA) buffer configured to store at least a portion of a DFA graph, the DFA graph comprising a plurality of nodes, each of the nodes having zero or more arcs each including a respective label and pointing to a respective subsequent node of the plurality of nodes, at least one of the plurality of nodes comprising a match node, wherein the at least portion of the DFA graph comprises one or more slots of a memory slice, the one or more slots comprising data representing one or more of the arcs for at least one node of the plurality of nodes, and a DFA engine implemented in circuitry, the DFA engine comprising one or more DFA threads implemented in circuitry and configured to evaluate a payload relative to the DFA graph.

Abstract: An example integrated circuit includes a memory including a non-deterministic finite automata (NFA) buffer configured to store a plurality of instructions defining an ordered sequence of instructions of at least a portion of an NFA graph, the portion of the NFA graph comprising a plurality of nodes arranged along a plurality of paths. The NFA engine determines a current symbol and one or more subsequent symbols of a payload segment that satisfy a match condition specified by a subset of instructions of the plurality of instructions for a path of the plurality of paths and in response to determining the current symbol and the one or more subsequent symbols of the payload segment that satisfy the match condition, outputs an indication that the payload data has resulted in a match.