Abstract: Disclosed and described systems, methods, and apparatus provide facilitate detection, processing, and relevancy analysis of clinical data. An example data event processing system includes a data event processor configured to receive a data event and to trigger, based on receipt of the data event, processing of the data event with respect to a clinical scenario. The example system includes a data relevancy processor configured to process the data event by applying natural language processing and machine learning to the data event based on the clinical scenario and to determine relevancy of the data event with respect to the clinical scenario based on a combination of domain knowledge and user knowledge. The example system includes an interface configured to output the data event and an indication of the relevancy of the data event with respect to the clinical scenario.