Patents by Inventor Edwin G. Duffin
Edwin G. Duffin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9101772Abstract: A method of stimulation therapy and an apparatus for providing the therapy which addresses cardiac dysfunction including heart failure. The therapy employs atrial pacing pulses delivered to a heart after the atrial refractory period and timed so that they will not cause a ventricular contraction. These atrial pacing are timed to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.Type: GrantFiled: December 9, 2009Date of Patent: August 11, 2015Assignee: Medtronic, Inc.Inventors: Karen J. Kleckner, Kathleen A. Prieve, Jeffrey M. Gillberg, Ren Zhou, Kenneth M. Anderson, D. Curtis Deno, Glenn C. Zillmer, Ruth N. Klepfer, Vincent E. Splett, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel, John E. Burnes
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Publication number: 20120303084Abstract: The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.Type: ApplicationFiled: August 8, 2012Publication date: November 29, 2012Applicant: Medtronic, Inc.Inventors: Karen J. Kleckner, Kathleen A. Prieve, Jeffrey M. Gillberg, Ren Zhou, Kenneth M. Anderson, D. Curtis Deno, Glenn C. Zillmer, Ruth N. Klepfer, Vincent E. Splett, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel, John E. Burnes
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Patent number: 8244355Abstract: A system and method are provided for determining an index of autonomic nervous system (ANS) or sympathetic nervous system (SNS) activity for use in patient monitoring or therapy delivery control. An ANS or SNS index is calculated as a function of multiple monitored physiological variables that strongly correlate to changes in autonomic or sympathetic tone. These ANS-influenced variables are derived from selected hemodynamic and/or electrical signals and may include variables relating to any of: the maximum rate of pressure rise (dP/dtmax), the maximum rate of pressure decline (dP/dtmin), pulse pressure (PP), pre-ejection time interval (PEI) and/or systolic time interval (STI), heart rate (HR), heart rate variability (HRV), and baro-reflex gain. Changes in the ANS or SNS index may be used to automatically adjust a device delivered therapy.Type: GrantFiled: October 29, 2004Date of Patent: August 14, 2012Assignee: Medtronic, Inc.Inventors: Tommy D. Bennett, Edwin G. Duffin, Barbro Kjellstrom
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Publication number: 20100152804Abstract: The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.Type: ApplicationFiled: December 9, 2009Publication date: June 17, 2010Applicant: Medtronic, Inc.Inventors: Karen J. Kleckner, Kathleen A. Prieve, Jeffrey M. Gillberg, Ren Zhou, Kenneth M. Anderson, D. Curtis Deno, Glenn C. Zillmer, Ruth N. Klepfer, Vincent E. Splett, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel, John E. Burnes
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Patent number: 7292888Abstract: A medical device, e.g., an implantable medical device, delivers one or more neurally-excitable stimulation pulses to myocardial tissue during a period when the tissue is refractory. The width of the pulses is less than or equal to approximately one half millisecond. In some embodiments, the current amplitude of the pulses is less than or equal to approximately twenty milliamps. In exemplary embodiments, the medical device delivers a pulse train of six or fewer pulses separated from each other by an interval that is greater than or equal to approximately ten milliseconds. In some embodiments, the medical device delivers pulses according to a schedule stored in a memory, or as a function of a monitored physiological parameter of a patient, such as an intracardiac pressure. In some embodiments, the medical device suspends or withholds delivery of neurally-excitable based on detection of cardiac ischemia.Type: GrantFiled: August 11, 2003Date of Patent: November 6, 2007Assignee: Medtronic, Inc.Inventors: D. Curtis Deno, David E. Euler, Lawrence J. Mulligan, Edwin G. Duffin, David A. Igel
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Patent number: 7047083Abstract: A method and apparatus for automatically detecting and diagnosing lead-related conditions is provided. Specifically, relatively short-term and relatively long-term impedance parameters are determined for detecting an impedance trend indicative of a lead-related condition such as an open circuit, which may be due to a conductor fracture or poor connection to an associated implantable medical device, or a short circuit due to an insulation breach. Monitoring of multiple lead impedance parameters is performed to diagnose a lead-related condition based on a number of diagnostic criteria. Supplementary analysis of multiple lead impedance parameter trends may be performed to identify lead-specific conditions, such as metal ion oxidation induced insulation degradation. A lead-related condition diagnosis and supporting data are stored in memory for uplinking to an external device for review by a clinician.Type: GrantFiled: September 30, 2002Date of Patent: May 16, 2006Assignee: Medtronic, Inc.Inventors: Bruce D. Gunderson, Amisha S. Patel, Chad A. Bounds, Edwin G. Duffin
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Patent number: 6915157Abstract: An implantable heart monitor (IHM) implanted in a patient's body having electrogram (EGM) sense electrodes coupled with EGM sense circuitry to generate sense events upon detection of cardiac depolarizations and a blood pressure measurement transducer disposed in a heart chamber and coupled with blood pressure measurement circuitry operates to assess heart failure state as a function of mechanical pulsus alternans (MPA). MPA episodes are detected, and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.Type: GrantFiled: February 18, 2003Date of Patent: July 5, 2005Assignee: Medtronic, Inc.Inventors: Tommy D. Bennett, Lawrence J. Mulligan, Edwin G. Duffin, Robert C. Hamlen, Wael Abo-Auda
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Publication number: 20040267328Abstract: A lead electrode, from an array of lead electrodes, is selectively coupled to a pulse generator device by positioning a lead connector including an array of connector contacts corresponding to the array of lead electrodes within a connector bore of the device for electrical engagement of a selected connector contact from the array of connector contacts with a device contact; the selected connector contact corresponding to the selected electrode.Type: ApplicationFiled: June 24, 2003Publication date: December 30, 2004Applicant: Medtronic, Inc.Inventors: Edwin G. Duffin, Thomas D. Brostrom
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Publication number: 20040162497Abstract: An implantable heart monitor (IHM) implanted in a patient's body having electrogram (EGM) sense electrodes coupled with EGM sense circuitry to generate sense events upon detection of cardiac depolarizations and a blood pressure measurement transducer disposed in a heart chamber and coupled with blood pressure measurement circuitry operates to assess heart failure state as a function of mechanical pulsus alternans (MPA). MPA episodes are detected, and MPA characteristics of the MPA episode are used alone or as a group as a diagnostic marker of HF state. The MPA episode data set can be stored in memory associated with a time and date stamp. The MPA characteristics of each MPA data set in a series of MPA data sets collected over time can be compared or plotted to determine if a trend indicative of change in HF state is discernible.Type: ApplicationFiled: February 18, 2003Publication date: August 19, 2004Inventors: Tommy D. Bennett, Lawrence J. Mulligan, Edwin G. Duffin, Robert C. Hamlen, Wael Abo-Auda
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Publication number: 20040064161Abstract: A method and apparatus for automatically detecting and diagnosing lead-related conditions is provided. Specifically, relatively short-term and relatively long-term impedance parameters are determined for detecting an impedance trend indicative of a lead-related condition such as an open circuit, which may be due to a conductor fracture or poor connection to an associated implantable medical device, or a short circuit due to an insulation breach. Monitoring of multiple lead impedance parameters is performed to diagnose a lead-related condition based on a number of diagnostic criteria. Supplementary analysis of multiple lead impedance parameter trends may be performed to identify lead-specific conditions, such as metal ion oxidation induced insulation degradation. A lead-related condition diagnosis and supporting data are stored in memory for uplinking to an external device for review by a clinician.Type: ApplicationFiled: September 30, 2002Publication date: April 1, 2004Inventors: Bruce D. Gunderson, Amisha S. Patel, Chad A. Bounds, Edwin G. Duffin
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Patent number: 6292698Abstract: A system for communicating with a medical device implanted in an ambulatory patient and for locating the patient in order to selectively monitor device function, alter device operating parameters and modes and provide emergency assistance to and communications with a patient. The implanted device includes a telemetry transceiver for communicating data and operating instructions between the implanted device and an external patient communications control device that is either worn by or located in proximity to the patient within the implanted device transceiving range. The control device preferably includes a communication link with a remote medical support network, a global positioning satellite receiver for receiving positioning data identifying the global position of the control device, and a patient activated link for permitting patient initiated personal communication with the medical support network.Type: GrantFiled: March 20, 1998Date of Patent: September 18, 2001Assignee: Medtronic, Inc.Inventors: Edwin G. Duffin, David L. Thompson, Steven D. Goedeke, Gregory J. Haubrich
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Patent number: 6230059Abstract: An implantable medical device (IMD) capable of monitoring physiologic data, distinguishing relatively noisy and noise free physiologic data, and recording noisy and relatively noise free segments of physiologic data in separate memory registers of a limited memory for retrieval and analysis at a later time. Preferably the physiologic data comprises the sampled EGM of the heart detected from sense electrode pairs that are implanted in the patient at sites where extraneous electrical noise, e.g., electromyographic signals, are also capable of being detected. The sense electrode pairs can constitute one or both sense electrodes located on or adjacent to the atrial and/or ventricular heart chambers and coupled to the IMD by a lead body or sense electrode pairs that are located remotely from the heart, e.g. at a subcutaneous implantation site of the IMD.Type: GrantFiled: March 17, 1999Date of Patent: May 8, 2001Assignee: Medtronic, Inc.Inventor: Edwin G. Duffin
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Patent number: 5752976Abstract: A system and method for communicating with a medical device implanted in an ambulatory patient and for locating the patient in order to selectively monitor device function, alter device operating parameters and modes and provide emergency assistance to and communications with a patient. The implanted device includes a telemetry transceiver for communicating data and operating instructions between the implanted device and an external patient communications control device that is either worn by or located in proximity to the patient within the implanted device transceiving range. The control device preferably includes a communication link with a remote medical support network, a global positioning satellite receiver for receiving positioning data identifying the global position of the control device, and a patient activated link for permitting patient initiated personal communication with the medical support network.Type: GrantFiled: June 23, 1995Date of Patent: May 19, 1998Assignee: Medtronic, Inc.Inventors: Edwin G. Duffin, David L. Thompson, Steven D. Goedeke, Gregory J. Haubrich
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Patent number: 5674251Abstract: A pacemaker system adapted to deliver pacing pulses in the presence of fibrillation. The pacing pulses are delivered via large surface area electrodes of the type normally used to accomplish defibrillation or cardioversion using high voltage pulses. An extended pulse train is delivered in order to gradually entrain greater portions of heart tissue, until a sufficient percentage of tissue is entrained to interrupt fibrillation. The invention is believed most applicable to treatment of atrial fibrillation.Type: GrantFiled: March 26, 1996Date of Patent: October 7, 1997Assignee: Medtronic, Inc.Inventors: William J. Combs, Edwin G. Duffin, T. V. Rao
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Patent number: 5562708Abstract: A pacemaker system adapted to deliver pacing pulses in the presence of fibrillation. The pacing pulses are delivered via large surface area electrodes of the type normally used to accomplish defibrillation or cardioversion using high voltage pulses. An extended pulse train is delivered in order to gradually entrain greater portions of heart tissue, until a sufficient percentage of tissue is entrained to interrupt fibrillation. The invention is believed most applicable to treatment of atrial fibrillation.Type: GrantFiled: April 21, 1994Date of Patent: October 8, 1996Assignee: Medtronic, Inc.Inventors: William J. Combs, Edwin G. Duffin, T. V. Rao
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Patent number: 5374279Abstract: A medical electrical pulse generator having a switchable connector assembly. The connector assembly is provided with connector bores, each intended to receive a medical electrical lead or a sealing plug, if no lead is provided. Electrical connectors located within the bores are arranged such that interconnection of the pulse generator circuitry within the device and electrodes on the leads and/or housing of the device can be altered by means of connector pins located on the electrical leads or the sealing plugs, which may be employed to interconnect electrical connectors within a connector bore.Type: GrantFiled: October 30, 1992Date of Patent: December 20, 1994Assignee: Medtronic, Inc.Inventors: Edwin G. Duffin, Jr., Warren S. Watson, Karel F. A. A. Smits
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Patent number: 5243978Abstract: A pacemaker system adapted to delivery pacing pulses in the presence of tachycardia or bradycardia. The pacing pulses are delivered via large surface area electrodes of the type normally used to accomplish defibrillation or cardioversion. Delivery of pacing pulses using the large surface area electrodes results in a more simultaneous depolarization of the heart tissue and is believed beneficial to improve hemodynamic efficiency of paced heart beats and in terminating detected tachyarrhythmias.Type: GrantFiled: October 7, 1991Date of Patent: September 14, 1993Assignee: Medtronic, Inc.Inventor: Edwin G. Duffin, Jr.
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Patent number: 5193550Abstract: A method and apparatus for discriminating among the various normal and pathologic tachycardias. In response to the detection of tachycardia, far-field ventricular electrograms sensed using atrial electrodes and far-field atrial electrograms sensed using ventricular electrodes are analyzed in order to categorize the source and type of tachyarrhythmia detected. The detection method and apparatus may be employed in conjunction with dual chamber anti-bradycardia pacemakers to avoid pacemaker mediated tachycardias or may be employed to mediate the delivery of pacing energy or cardioversion/defibrillation shock energy to a malfunctioning heart, in the context of an implantable antitachycardia device.Type: GrantFiled: November 30, 1990Date of Patent: March 16, 1993Assignee: Medtronic, Inc.Inventor: Edwin G. Duffin
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Patent number: 5133350Abstract: A mode switching bradycardia pacemaker especially adapted for incorporation in an antitachyarrhythmia pacing and/or cardioversion/defibrillation system, provides AAI pacing in the absence of an intrinsic atrial rate exceeding the pacing lower rate and as long as the patient's heart is capable of normal AV conduction. The pacemaker switches to VVI mode any time that the patient's ventricular rate falls below a predetermined value. The mode switching may be implemented in a DDD pacing system or in a pacing system employing an atrial and ventricular sense amplifier and a single pacing output circuit and switching circuitry for switching its output between atrial and ventricular leads.Type: GrantFiled: January 31, 1991Date of Patent: July 28, 1992Assignee: Medtronic, Inc.Inventor: Edwin G. Duffin
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Patent number: 4505276Abstract: A pacing system analyzer is constructed to provide verification that an implantable cardiac pacer operating in a demand mode will not itself produce tachycardia in a patient because of abnormally long patient retrograde conduction time. The analyzer when performing the retrograde conduction test provides an intercardiac electrogram, changes the ventricular sense amplifier to asynchronous and samples to determine the maximum amplitude signals over a sampling period to select an amplifier gain factor. After the gain factor is set additional signal samples are collected, peak-to-peak amplitude is measured and interpolation between data is made to provide waveform "segments" and the best waveform segment to employ for testing for retrograde conduction is selected. The time periods from pacing to these segments are measured and utilized to determine if retrograde conduction is present.Type: GrantFiled: June 15, 1983Date of Patent: March 19, 1985Assignee: Medtronic, Inc.Inventors: Harold T. Markowitz, John C. Rueter, Edwin G. Duffin