Abstract: Described herein are devices, systems, and methods to aid in the manipulation of cells. The devices, methods, and systems disclosed herein can be applied towards, for example, automation of the in vitro fertilization process.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: Described herein are devices, systems, and methods to facilitate cryopreservation of a cell or a mass of a plurality of cells such as oocytes or embryos. A device of the disclosure can, for example, store oocytes or embryos during the vitrification and/or warming processes of in vitro fertilization.

Abstract: Described herein are devices, systems, and methods to aid in the manipulation of cells. The devices, methods, and systems disclosed herein can be applied towards, for example, automation of the in vitro fertilization process.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that we arranged to apply a force to the ring at spaced control points.

Abstract: The present invention provides a deformable membrane assembly 1 comprising an elastic membrane 8 that is held under tension around its edge by a bendable membrane supporting member 2,10, a body of fluid in contact with one face of the membrane, the pressure of the fluid being controllable for adjusting the shape of the membrane, and one or more bending controllers 24 acting on the supporting member 2, 10 to control the bending of the supporting member in response to loading through tension in the membrane. The bending stiffness of the membrane-supporting member 2, 10 varies round its extent to control the profile of the edge of the membrane 8; etc. upon actuation. A variety of different types of bending controllers are disclosed which permit out-of-plane bending of the supporting member 2, 10 but prevent or control in-plane bending or deformation of the supporting member.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: A deformable membrane assembly comprising a fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a bendable supporting ring, a support for the envelope and at least three ring-engaging members that are arranged to apply a force to the ring at spaced control points for adjusting the shape of the membrane, with the ring bending to control the shape of the membrane to a predefined form. A control point is provided at or proximate each point on the ring where the profile of the ring that is needed to produce the predefined form of the membrane exhibits a turning point in the direction of the force applied at the control point between two adjacent points where the profile of the ring exhibits an inflection point or a turning point in the opposite direction.

Abstract: A deformable membrane assembly comprises an at least partially flexible fluid-filled envelope, one wall of which is formed by an elastic membrane that is held around its edge by a resiliently bendable supporting ring, a fixed support for the envelope and selectively operable means for causing relative movement between the supporting ring and the support for adjusting the pressure of the fluid in the envelope, thereby to cause the membrane to deform. The bending stiffness of the ring varies round the ring such that upon deformation of the membrane the ring bends variably to control the shape of the membrane to a predefined form. The moving means comprise a plurality of ring-engaging members that are arranged to apply a force to the ring at spaced control points.

Abstract: The present invention provides a deformable membrane assembly 1 comprising an elastic membrane 8 that is held under tension around its edge by a bendable membrane supporting member 2,10, a body of fluid in contact with one face of the membrane, the pressure of the fluid being controllable for adjusting the shape of the membrane, and one or more bending controllers 24 acting on the supporting member 2, 10 to control the bending of the supporting member in response to loading through tension in the membrane. The bending stiffness of the membrane-supporting member 2, 10 varies round its extent to control the profile of the edge of the membrane 8; etc. upon actuation. A variety of different types of bending controllers are disclosed which permit out-of-plane bending of the supporting member 2, 10 but prevent or control in-plane bending or deformation of the supporting member.

Abstract: A dispensing system comprising: a main body having an electrically driven SMA actuator; a container for a medium to be dispensed, the container being separate from, but connectable to, the main body; a dispenser, a portion of which is, in use, to be located within the container and moveable relative thereto so as to selectively dispense a portion of the medium, the dispenser also being arranged to be connected in use to the actuator of the main body: wherein the actuator is arranged to cause relative movement between the container and the dispenser in order to dispense a predetermined portion of the medium.