Abstract: The present invention is a number of single piece unit dose delivery systems. Five related embodiments are disclosed with a number of variations with each embodiment. All embodiments are basically a dispensing system with a containment structure holding a single unit dose of materials for a particular procedure. The containment structure may be either a bulbous tube or a tubular structure attached to a valve body which is also attached to a cannula, of any shape, opposite the structure. A distribution means is located at a tip of the cannula. The valve body may be constructed to block initial communication between the containment structure and the cannula by employing a sealing diaphragm, a plunger apparatus, or by utilizing pull or twist-apart valve structures. Establishing communication is then accomplished by either breaking the diaphragm, as with a needle or other sharp object, or activation the valve, be it a plunger, pull apart or twist-apart variety.