Patents by Inventor Edwin Vazquez-Cintron

Edwin Vazquez-Cintron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Propeptide fusion comprising a mutated clostridium botulinum neurotoxin and a VHH domain
    Patent number: 11897921
    Abstract: The present invention is directed to a fusion protein comprising a light chain region of a Clostridial neurotoxin and a heavy chain region of a Clostridial neurotoxin, where the light and heavy chain regions are linked by a disulfide bond. The fusion protein also has a single chain antibody positioned upstream of the light chain region, where the single chain antibody possesses antigen-binding activity. Also disclosed are therapeutic agents, treatment methods, propeptide fusions, isolated nucleic acid molecules, expression systems, host cells, and methods of expressing fusion proteins.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: February 13, 2024
    Assignee: NEW YORK UNIVERSITY
    Inventors: Konstantin Ichtchenko, Edwin Vazquez-Cintron, Philip A. Band, Timothy J. Cardozo
  • CLOSTRIDIAL NEUROTOXIN FUSION PROTEINS, PROPEPTIDE FUSIONS, THEIR EXPRESSION, AND USE
    Publication number: 20160159866
    Abstract: The present invention is directed to a fusion protein comprising a light chain region of a Clostridial neurotoxin and a heavy chain region of a Clostridial neurotoxin, where the light and heavy chain regions are linked by a disulfide bond. The fusion protein also has a single chain antibody positioned upstream of the light chain region, where the single chain antibody possesses antigen-binding activity. Also disclosed are therapeutic agents, treatment methods, propeptide fusions, isolated nucleic acid molecules, expression systems, host cells, and methods of expressing fusion proteins.
    Type: Application
    Filed: December 9, 2015
    Publication date: June 9, 2016
    Applicant: New York University
    Inventors: Konstantin Ichtchenko, Edwin Vazquez-Cintron, Philip A. Band, Timothy J. Cardozo